Charged mobile complexes in magnetic fields: A novel selection rule for magneto-optical transitions

The implications of magnetic translations for internal optical transitions of charged mobile electron-hole ($e$--$h$) complexes and ions in a uniform magnetic field $B$ are discussed. It is shown that transitions of such complexes are governed by a novel exact selection rule. Internal intraband transitions of two-dimensional (2D) charged excitons $X^-$ in strong magnetic fields are considered as an illustrative example.Comment: 4 pages, 2 figure

Braggoriton--Excitation in Photonic Crystal Infiltrated with Polarizable Medium

Light propagation in a photonic crystal infiltrated with polarizable molecules is considered. We demonstrate that the interplay between the spatial dispersion caused by Bragg diffraction and polaritonic frequency dispersion gives rise to novel propagating excitations, or braggoritons, with intragap frequencies. We derive the braggoriton dispersion relation and show that it is governed by two parameters, namely, the strength of light-matter interaction and detuning between the Bragg frequency and that of the infiltrated molecules. We also study defect-induced states when the photonic band gap is divided into two subgaps by the braggoritonic branches and find that each defect creates two intragap localized states inside each subgap.Comment: LaTeX, 8 pages, 5 figure

ВИЧ-ИНФЕКЦИЯ И ВИЧ-АССОЦИИРОВАННЫЙ ТУБЕРКУЛЕЗ У ДЕТЕЙ УКРАИНЫ

The article presents data on the epidemiology of HIV infection and co-infection with HIV/TB in children in Ukraine. Along with the increasing number of HIV-infected women of reproductive age and their children, it is mentioned the growth of tuberculosis among HIV-infected children. The problems of adequate monitoring and management of these patients, in particular with regard to the prevention of tuberculosis among them are described. There are made conclusions about the need to improve the delivery system of TB care for children born by HIV-infected mothers.В статье представлены данные об эпидемиологической ситуации по ВИЧ-инфекции и ко-инфекции ВИЧ/туберкулез у детей на Украине. Наряду с увеличением числа ВИЧ-инфицированных женщин детородного возраста и рожденных ими детей отмечен рост заболеваемости туберкулезом среди ВИЧ-инфицированных детей. Освещаются вопросы адекватного наблюдения и ведения этой категории пациентов, в частности трудности профилактики у них туберкулеза. Сделаны выводы о необходимости совершенствования системы оказания противотуберкулезной помощи детям, рожденным от ВИЧ-инфицированных матерей

HIV INFECTION AND HIV-ASSOCIATED TUBERCULOSIS IN CHILDREN IN UKRAINE

The article presents data on the epidemiology of HIV infection and co-infection with HIV/TB in children in Ukraine. Along with the increasing number of HIV-infected women of reproductive age and their children, it is mentioned the growth of tuberculosis among HIV-infected children. The problems of adequate monitoring and management of these patients, in particular with regard to the prevention of tuberculosis among them are described. There are made conclusions about the need to improve the delivery system of TB care for children born by HIV-infected mothers

Synthesis, microstructure and effect of high pressures on transport properties of GdBaCo2O5,5

In polycrystalline samples of double layered cobaltite GdBaCo2O5.5 the structure and resistivity at the first order “insulator-metal” (I-M) phase transition were studied at normal and high pressures. The strong dependence of the shape of the temperature hysteresis loop on the rate of temperature change indicates an infra-slow thermal relaxation of conductivity. Baric studies have shown an increase in the transition temperature ТIM at increasing pressure P with baric coefficient dТIM/dP ≈ 10 K/GPa. The spin blockade model is used to explain the observed effects.</jats:p

The genetic landscape of high-risk neuroblastoma

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 affected individuals (cases) using a combination of whole-exome, genome and transcriptome sequencing as part of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative. Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in these tumors. Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN11 (2.9%), ATRX (2.5%, and an additional 7.1% had focal deletions), MYCN (1.7%, causing a recurrent p.Pro44Leu alteration) and NRAS (0.83%). Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1 and BARD1. The relative paucity of recurrent somatic mutations in neuroblastoma challenges current therapeutic strategies that rely on frequently altered oncogenic drivers.National Human Genome Research Institute (U.S.) (Grant U54HG003067)National Cancer Institute (U.S.) (Contract HHSN261200800001E

Mechanisms of drug combinations: Interaction and network perspectives

10.1038/nrd2683Nature Reviews Drug Discovery82111-12