Uncommon secondary metabolites from <i>Etlingera pavieana</i> rhizomes

<p>From the rhizomes of <i>Etlingera pavieana</i> (Pierre ex Gagnep.) R.M. Sm., four phenylpropens, (<i>E</i>)-3-(4-methoxyphenyl)prop-2-en-1-amine (<b>1</b>), (<i>E</i>)-4-methoxycinamaldehyde (<b>2</b>), (<i>E</i>)-4-methoxycinamic acid (<b>3</b>) and (<i>E</i>)-1-methoxy-4-(3-methoxyprop-1-enyl)benzene (<b>4</b>), together with two other compounds, (<i>E</i>)-((<i>E</i>)-3-(4-methoxyphenyl)allyl)3-(4-hydroxyphenyl)acrylate (<b>5</b>) and 4-methoxybenzoic acid (<b>6</b>) were isolated. This is the first report on the presence of all compounds in <i>Etlingera</i>. Compounds <b>1</b> and <b>5</b> have been previously synthesised, but this is the first report of their isolation from a natural source. Compound <b>5</b> exhibited weak activity against <i>Mycobacterium tuberculosis</i> with MIC 50.00 μg/mL and cytotoxic activity against the KB, MCF7 and NCI-H187 cells with IC₅₀ values of 25.11, 20.16 and 34.83 μg/mL, respectively.</p