CORONARY STATUS, PHYSICAL CAPACITY, LEFT VENTRICULAR FUNCTION AND PROGNOSIS IN MEDICALLY STABILIZED PATIENTS WITH UNSTABLE ANGINA

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SEXUAL ACTIVITY BEFORE AND AFTER CORONARY ARTERY BYPASS GRAFTING

Improved functional capacity after coronary surgery implies that a better level of any aspects of quality of life, sexual activity inclusive, could be expected. The aim of this study was to evaluate the changes in the sexual activity in the patients with coronary artery disease having undergone coronary artery bypass grafting (CABG). The mean age of the contingent of 18 male and 2 female patients was 58 ±5,6 (range 44-66) years. After clinical examination the patients completed a sexual activity questionnaire and an exercise test 20 ±14 (range 4—52) months after CABG. All the patients were married and had permanent sexual partner. At the time of the observation 6 patients (30%) were symptomatic. Data about angina pectoris was available for 5 patients, and one patient experienced symptoms of heart failure. The NYHA class of the patients increased significantly after CABG (1,9 ±0,8 vs 3,1 ±0,5, p 0,001). Only 5 (25%) patients reported increased sexual activity after CABG. Fourteen (70%) patients reported no change in the sexual activity and one (5%) patient had decreased sexual intercourse frequency. After CABG, 16 patients (80%) used beta-blockers. Although the NYHA class of the patients increased significantly after CABG, a few of them experienced an improved sexual activity. Possible reasons were the psychological problems (depression, fear of sexual failure, lack of appreciation and support by the sexual partner), diabetes mellitus, beta-blocker usage, etc. The physician in charge of the CABG patient should ask actively for sexual problems and refer the patient to specialized evaluation when needed

LEFT VENTRICULAR HYPERTROPHY, LEFT VENTRICULAR FUNCTION AND BETABLOCKERS IN PATIENTS WITH ESSENTIAL HYPERTENSION

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EARLY ATRIAL PACING TEST FOR MYOCARDIAL CONTRACTILITY EVALUATION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

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LEFT VENTRICULAR RELAXATION AND RAPID FILLING IN PATIENTS WITH ESSENTIAL HYPERTENSION AND UNSTABLE ANGINA PECTORIS

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EARLY VELOERGOMETRIC TEST AND ATRIAL PACING TEST IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

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Practical significance of individual blood pressure trajectories

Individual blood pressure values tend to be close to a certain population pattern (because of environmental and socioeconomic factors), without fully following it (because of specifi c individual genetic predisposition). These population "patterns" or "trajectories' can be followed back to prenatal period and across the whole lifespan. Some of them are correlated with higher risk for development of arterial hypertension. There are also several "cornerstones" in these patterns, where the individual may be at an increased risk for movement to a higher-risk group. They can explain why certain individuals are more prone to target organ damage than others and why we, as clinicians, should have an individualized approach when we translate population-based guidelines to the single patient. Proper defi nition and practical knowledge of the signifi cance of these blood pressure trajectories could be important for everyday prophylaxis and practice

In Vitro Model of Latent Mycobacterial Infection

A new in vitro culture model for latency of tuberculosis pathogen suitable for screening chemical libraries was developed by subjecting the pathogen to multiple stresses that the pathogen is thought to encounter in the host. When subjected to these stress factors, the pathogen develops key features characteristic of latency, drug resistance and lipid storage. Using the culture, a method to screen chemicals was developed. This method is suitable for high through put screening

In vitro model of latent mycobacterial infection (DIV II)

A new in vitro culture model for latency of tuberculosis pathogen suitable for screening chemical libraries was developed by subjecting the pathogen to multiple stresses that the pathogen is thought to encounter in the host. When subjected to these stress factors, the pathogen develops key features characteristic of latency, drug resistance and lipid storage. Using the culture, a method to screen chemicals was developed. This method is suitable for high through put screening