Antibacterial activities of root canal sealers against selected anaerobic bacteria

The antibacterial effects of four endodontic sealers were evaluated on six anaerobic bacteria and two facultative anaerobes commonly isolated from infected root canals, Calcium hydroxide powder mixed with saline solution was also tested, The agar diffusion test was used, and the zones of inhibition around each sealer were recorded and compared, Fill Canal, a zinc oxide-eugenol-based sealer, showed large zones of inhibition against all bacteria tested, Sealer 26, an epoxy resin containing calcium hydroxide, was inhibitory to most of the strains, but it was not effective against Porphyromonas endodontalis and Porphyromonas gingivalis, Next in order was calcium hydroxide followed by Sealapex, both with low activity, Apexit showed no antibacterial activity, Difficulties in interpreting the results of agar diffusion tests are recognized.222798

Evaluation of the antibacterial activities of calcium hydroxide, chlorhexidine, and camphorated paramonochlorophenol as intracanal medicament. A clinical and laboratory study

The antibacterial activities of camphorated paramonochlorophenol, chlorhexidine, and calcium hydroxide were compared using a clinical and laboratory evaluation. In the clinical experiment, root canals that yielded positive cultures a week after complete chemomechanical preparation and camphorated paramonochlorophenol dressing were medicated with one of the three substances tested. Postmedication samples were taken from the canal 1 week later. In the laboratory experiment, the agar diffusion test was used to evaluate the inhibitory activity of the medicaments against bacteria commonly found in endodontic infections. The results of the clinical evaluation showed that all medicaments were effective in reducing or eliminating the endodontic microbiota, as demonstrated by the incidence of negative cultures. There was no statistically significant difference among the medicaments tested. In the laboratory evaluation, camphorated paramonochlorophenol showed the largest zones of bacterial inhibition against all bacterial strains tested.23529730