Factors associated with mortality in a neonatal intensive care unit

Aims: To describe the factors associated with mortality of newborns hospitalized in a Neonatal Intensive Care Unit in the period from 2012 to 2015. Methods: This was a descriptive, quantitative study of secondary data, correlated with the causes of death and hospitalization according to classification by ICD-10.  The categorical variables were presented in absolute and relative frequencies, with measurements of central tendency and dispersion. Evaluation of the factors associated with neonatal death was made by the logit model of analysis with correction of robust errors by the statistical program Stata 12.0, considering values of p<0.05 and interval of confidence of 95%.  Results: Of the 563 newborns, 58.6% were of the male sex; 89.0% were early newborns, 73.0% were premature. 181 newborns died (32.3%). The main causes of hospitalization were: difficulties during birth, conditions of birth and immaturity (45.0%), pathologies associated with the respiratory system (21.1%), congenital malformations (9.7%). The main causes of death were: septicemia of the NB (40.4%), respiratory discomfort of the NB (22.4%). The significant associations for mortality were the use of ventilatory supports: Mechanical Ventilation (p=0.001), Hallo (p=0.000), CPAP (p=0.000), VNI (p=0.005). Conclusions: The major risk factors for neonatal mortality were associated with septicemia and use of mechanical ventilation

Congenital malformations in neonates: analysis of morbidity and associated factors

Objective: To evaluate the neonatal morbidity due to congenital malformations in the city of Petrolina-PE, from 2008 to 2013. Methods: A descriptive study with data from the Information System on Live Births (Sinasc). The analyzes were carried out through frequency distribution and measures of central tendency and dispersion. The associations were tested by the Pearson and Kruskal Wallis chi-square tests. Significance was set at 5% and 95% confidence. Results: 436 cases of congenital malformations were recorded in the study period, with 2011 being the highest occurrence year. The mothers of the newborns were young (25.2 years old), single, upper level of education and household. In general multiparous, with single gestation, vaginal delivery and performed up to six prenatal visits. The newborns were males, at 39 weeks or more of gestation and with normal weight (> = 2500g). The malformations of the musculoskeletal system were the most frequent followed by the genitourinary system. Congenital malformations were especially associated with neonatal characteristics such as gender and weight. In all causes the mean weight was greater than 2500g (p <0.05). The causes of malformation of greater occurrence in both sexes were osteomuscular (p <0.05). The aspects of the mother did not present significant differences in the present study (p> 0.05). Conclusion: The present study evidenced relevant aspects in the occurrence of morbidities due to congenital malformations, directing to a greater attention the occurrence of these diseases especially in relation to the newborn

VIOLÊNCIA PSICOLÓGICA CONTRA MULHERES USUÁRIAS DA ATENÇÃO PRIMÁRIA À SAÚDE

Objetivo: Descrever a ocorrência da violência psicológica contra a mulher usuária da Atenção Primária à Saúde no município de Petrolina/PE e os fatores associados. Métodos: Estudo transversal, com 392 usuárias da Atenção Primária à Saúde. Foram realizadas entrevistas com mulheres de idade igual ou superior a 18 anos. Lançou-se mão da distribuição de frequência com intervalo de confiança assumindo a distribuição Binomial, testes Qui-Quadrado de Pearson e/ou Exato de Fisher e regressão logística binária. Adotou-se significância de 5%, confiança de 95%. Resultados: Foram entrevistadas 392 mulheres observando-se prevalência de 37,8% de violência psicológica. A maioria dos eventos ocorreu em domicílio, com agressores conhecidos. Fatores associados a ocorrência da violência psicológica foram a faixa etária e a escolaridade sendo significativo em mulheres mais jovens e com nível superior. Estas características aumentaram a chance de sofrer violência psicológica. A associação entre as características sociodemográficas e econômicas e o agressor apontou uma maior ocorrência em mulheres com filhos assim como uma maior participação do parceiro íntimo na agressão de mulheres com faixas etárias maiores. Conclusão: A ocorrência da violência psicológica perpetrada por conhecidos predominou e alguns fatores sociais apresentaram-se relacionados ao aumento da chance da ocorrência da violência

Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage

The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of SP from the green marine alga Caulerpa mexicana (Cm-SP) in ethanol-induced gastric damage models in mice. Cm-SP (2, 20, or 200 mg/kg), administered p.o., significantly reduced gastric damage, and these effects were inhibited through pretreatment with indomethacin. Cm-SP (200 mg/kg) prevented the ethanol-induced decline in glutathione and restored its normal level. Moreover, it was able to normalize the elevated thiobarbituric acid reactive substance levels. However, Cm-SP did not show any significant effects on NO2/NO3 level, when compared to the ethanol group. The pretreatment with L- NAME induced gastric mucosal damage and did not inhibit the gastroprotective effect of Cm-SP (200 mg/kg). In conclusion, the gastroprotective effects of Cm-SP in mice involve prostaglandins and reduction in the oxidative stress and are independent of NO