Demographic and occupational factors associated with depression identified from multiple linear regression model.

Demographic and occupational factors associated with depression identified from multiple linear regression model.</p

Dataset of the study can be found in S1 Data file.

(XLS)</p

Scores of workplace violence (WPV), bullying, burnout, job satisfaction, and depression.

Scores of workplace violence (WPV), bullying, burnout, job satisfaction, and depression.</p

Demographic and occupational characteristics of participants (n = 1,264).

Demographic and occupational characteristics of participants (n = 1,264).</p

Flowchart of the recruitment process.

Flowchart of the recruitment process.</p

Predicting factors of depression.

Predicting factors of depression.</p

Pearson’s correlations among workplace violence (WPV), bullying, burnout, job satisfaction, and depression.

Pearson’s correlations among workplace violence (WPV), bullying, burnout, job satisfaction, and depression.</p

Workplace violence (WPV), bullying, burnout, job satisfaction, and depression according to demographic and occupational characteristics.

Workplace violence (WPV), bullying, burnout, job satisfaction, and depression according to demographic and occupational characteristics.</p

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells

Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability. Protecting CPCs from undergoing cellular apoptosis during oxidative stress is crucial in optimizing CPC-based therapy. Histochrome (sodium salt of echinochrome A&mdash;a common sea urchin pigment) is an antioxidant drug that has been clinically used as a pharmacologic agent for ischemia/reperfusion injury in Russia. However, the mechanistic effect of histochrome on CPCs has never been reported. We investigated the protective effect of histochrome pretreatment on human CPCs (hCPCs) against hydrogen peroxide (H2O2)-induced oxidative stress. Annexin V/7-aminoactinomycin D (7-AAD) assay revealed that histochrome-treated CPCs showed significant protective effects against H2O2-induced cell death. The anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-xL were significantly upregulated, whereas the pro-apoptotic proteins BCL2-associated X (Bax), H2O2-induced cleaved caspase-3, and the DNA damage marker, phosphorylated histone (&gamma;H2A.X) foci, were significantly downregulated upon histochrome treatment of hCPCs in vitro. Further, prolonged incubation with histochrome alleviated the replicative cellular senescence of hCPCs. In conclusion, we report the protective effect of histochrome against oxidative stress and present the use of a potent and bio-safe cell priming agent as a potential therapeutic strategy in patient-derived hCPCs to treat heart disease