6 research outputs found
Flows in inkjet-printed aqueous rivulets
We used optical microscopy to investigate flows inside water rivulets that
were inkjet-printed onto different surfaces and under different ambient
conditions. The acquired fluid dynamics videos were submitted to the 2013
Gallery of Fluid Motion.Comment: This article accompanies a fluid dynamics video submitted to the 2013
Gallery of Fluid Motion of the 66th Annual Meeting of the APS Division of
Fluid Dynamic
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Electroless Copper Plating of Inkjet-Printed Polydopamine Nanoparticles: a Facile Method to Fabricate Highly Conductive Patterns at Near Room Temperature
Aqueous dispersions of artificially
synthesized, mussel-inspired poly(dopamine) nanoparticles were inkjet
printed on flexible polyethylene terephthalate (PET) substrates. Narrow
line patterns (4 μm in width) of poly(dopamine) resulted due
to evaporatively driven transport (coffee ring effect). The printed
patterns were metallized via a site-selective Cu electroless plating
process at a controlled temperature (30 °C) for varied bath times.
The lowest electrical resistivity value of the plated Cu lines was
about 6 times greater than the bulk resistivity of Cu. This process
presents an industrially viable way to fabricate Cu conductive fine
patterns for flexible electronics at low temperature, low cost, and
without need of sophisticated equipment
Interfacial Targeting of Sessile Droplets Using Electrospray
We
report on the use of electrospray atomization to deliver nanoparticles
and surfactant directly to the surface of sessile droplets. The particles
delivered to the target droplet remained adsorbed at its interface
since they arrived solvent-free. Upon complete evaporation, the interface
of the target drop was mapped to the underlying substrate, forming
a nanoparticle deposit. The use of electrospray permitted the exploration
of the interfacial particle transport and the role of surfactants
in governing particle motion and deposit structure. When no surfactant
was present in the sprayed solution, there was no observable convection
of the interfacial particles. When Tween 80, a high-molecular-weight
surfactant, was added to the sprayed solution, the surface flow was
similarly suppressed. Only when small surfactants (e.g., sodium dodecyl
sulfate) were present in the sprayed solution was Marangoni flow,
directed toward the droplet apex, induced at the interface. This flow
drove the interfacial particles to the apex of the target droplet,
creating a particle-dense region at the center of the final deposit.
We found that small surfactants were capable of desorbing from the
interface at a sufficiently high rate relative to the evaporation
time scale of the target droplet. Once inside the drop, the desorbed
surfactant was convected to the contact line where it accumulated,
inducing a surface tension gradient and a solutal Marangoni flow.
Numerical modeling using the lattice Boltzmann–Brownian dynamics
method confirmed this mechanism of particle transport and its relationship
to deposit structure. The use of sacrificial targets combined with
electrospray may provide a unique capability for building colloidal
monolayers with organized structure in a scalable way
Regulation of the Deposition Morphology of Inkjet-Printed Crystalline Materials via Polydopamine Functional Coatings for Highly Uniform and Electrically Conductive Patterns
We report a method to achieve highly
uniform inkjet-printed silver nitrate (AgNO<sub>3</sub>) and a reactive
silver precursor patterns on rigid and flexible substrates functionalized
with polydopamine (PDA) coatings. The printed AgNO<sub>3</sub> patterns
on PDA-coated substrates (glass and polyethylene terephthalate (PET))
exhibit a narrow thickness distribution ranging between 0.9 and 1
μm in the line transverse direction and uniform deposition profiles
in the line axial direction. The deposited reactive silver precursor
patterns on PDA-functionalized substrates also show “dome-shaped”
morphology without “edge-thickened” structure due to
“coffee-stain” effect. We posit that the highly uniform
functional ink deposits formed on PDA-coated substrates are attributable
to the strong binding interaction between the abundant catecholamine
moieties at the PDA surface and the metallic silver cations (Ag<sup>+</sup> or Ag(NH<sub>3</sub>)<sup>2+</sup>) in the solutal inks.
During printing of the ink rivulet and solvent evaporation, the substrate–liquid
ink (S–L) interface is enriched with the silver-based cations
and a solidification at the S/L interface is induced. The preferential
solidification initiated at the S–L interface is further verified
by the in situ visualization of the dynamic solidification process
during solvent evaporation, and results suggest an enhanced crystal
nucleation and growth localized at the S–L interface on PDA
functionalized substrates. This interfacial interaction mediates solute
transport in the liquid phase, resulting in the controlled enrichment
of solute at the S–L interface and mitigated solute precipitation
in both the contact line region and the liquid ink–vapor (L–V)
interface due to evaporation. This mediated transport contributes
to the final uniform solid deposition for both types of ink systems.
This technique provides a complementary strategy for achieving highly
uniform inkjet-printed crystalline structures, and can serve as an
innovative foundation for high-precision additive delivery of functional
materials