4 research outputs found
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 1, 2, 4-TRIAZOLE DERIVATIVES
Objectives: To synthesize, characterize and evaluate antimicrobial properties of some 1, 2, 4-triazole derivatives.
Methods: A novel series of 1, 2, 4-Triazole derivatives (D-1-D-8) had been synthesized. Ethyl esters of benzoic and 4-substituted benzoic acids were synthesized using ethanol and conc. sulphuric acid. In the second step, hydrazides of these esters were prepared. This hydrazide was converted into potassium salt of dithiocarbazinate using carbon disulfide and potassium hydroxide which on cyclization formed compounds (D-1-D-2). Compound D-3 was formed by reacting D-1 with 4-methylbenzenesulfonyl chloride in dry pyridine. Compounds (D-4-D-8) were synthesized by mixing aqueous solution of 10% NaOH in different primary amines and then heating it with potassium salt of dithiocarbazinate. The structures of newly synthesized compounds were established on the basis of 1H NMR and Mass spectroscopic techniques. The newly synthesized compounds were screened for their in vitro antibacterial and antifungal activity. In vitro antibacterial and antifungal activity was evaluated by Disc Diffusion method. Ofloxacin and Clotrimazole were used as standard drug respectively.
Results: The results revealed that compounds D-3 and D-4 exhibited good antibacterial activity and D-1 and D-2 had moderate antibacterial activity as compared with standard drug Ofloxacin, while compounds (D-5-D-8) exhibited moderate antifungal activity as compared to standard drug Clotrimazole.
Conclusion: A novel series of 1, 2, 4-Triazole derivatives were synthesized and were obtained in good yields. Newly synthesized compounds were isolated and purified by thin layer chromatography and column chromatography respectively
Variation in growth, production and quality attributes of
Introduction. Diverse fruit crops with a high value reduce the risk of crop
failure and offer alternatives to farmers and the market. The scope of profitable
production with such quality crops along with environmental concerns make the evaluation
of new species desirable. The aim of our study was to determine the most appropriate
species of Physalis for small-scale commercial production in the
temperate climate of western Himalayan regions. Materials and methods. Four
Physalis species, viz., P. peruviana,
P. ixocarpa, P. pruinosa and P. nicandroides, were
field-grown during 2010–2011 in the experimental field of the Central Institute of
Temperate Horticulture, Srinagar, India, to determine the most appropriate species of
Physalis suitable for a temperate climate. Results and
discussion. All the species tested produced vegetative growth, flowered and
fruited; however, they differed significantly. The number of basal shoots was found to be
maximum for P. pruinosa (6.37), whereas the maximum number of prickles
per shoot was recorded as maximum for P. nicandroides (6.48). The number
of points of attachment varied significantly with species, and the maximum was recorded
for P. pruinosa and P. ixocarpa (7.16 for each); the
maximum size of fully developed leaves (146.8 mm) and overall plant height (168.27 cm)
were recorded for P. pruinosa. Physalis pruinosa
and P. ixocarpa were found to exhibit vigorous growth under a
temperate climate. Significant differences were recorded for fruiting, flowering and yield
potential among the Physalis species. The minimum days taken for bud
burst were reported for P. nicandroides (23.55) and
P. ixocarpa (24.41). Similarly, the minimum days taken to reach
maturity were reported for P. peruviana (64.96). The maximum number of
fruits per plant (260.23), length of fruit (33.83 mm), average fruit weight (37.19 g),
husk weight (0.32 g), fruit husk ratio (121.27), maximum fruit firmness (43.96 Relative
Index) and yield (9.96 Relative Index) were recorded for P. pruinosa.
Significant variation was recorded in quality attributes. The highest total soluble solids
were found for P. nicandroides (8.46 °Brix), whereas the minimum total
titrable acidity (0.35%) and maximum ascorbic content (38.41 mg·100 g–1) were recorded for
P. peruviana. The ‘L’ value of fruits, showing
brightness, was recorded as the highest for P. peruviana (58.97), whereas
fruits of all the species showed a negative ‘a’ value, indicating that
none of them produced redness; however, the ‘b’ value, indicating
yellowness, was maximum for P. pruinosa (18.72)
The Majority‐Minority Divide in Attitudes toward Internal Migration: Evidence from Mumbai
Abstracts of International Conference on Innovations in Business Management
This book contains abstracts of the various research ideas of the academic community and practitioners of management presented at the International Conference on Innovations in Business Management (ICIBM 2020). The researchers have contributed toward various themes of the conference such as sustainable economy, supply chain, women-empowerment, export-import, microfinance, government policies, etc. We strongly believe that it will open up further scope for in-depth research in various disciplines of business management. Best wishes to the participants to have detailed discussions on the above-said wide range of areas.
Conference Title: International Conference on Innovations in Business ManagementConference Acronym: ICIBM 2020Conference Date: 16-17 January 2020Conference Location: ICFAI University, Dehradun, IndiaConference Organizers: ICFAI Business School, ICFAI University, Dehradun, India & University of Derby, United Kingdo