The interaction energy of well-separated Skyrme solitons

We prove that the asymptotic field of a Skyrme soliton of any degree has a non-trivial multipole expansion. It follows that every Skyrme soliton has a well-defined leading multipole moment. We derive an expression for the linear interaction energy of well-separated Skyrme solitons in terms of their leading multipole moments. This expression can always be made negative by suitable rotations of one of the Skyrme solitons in space and iso-space.We show that the linear interaction energy dominates for large separation if the orders of the Skyrme solitons' multipole moments differ by at most two. In that case there are therefore always attractive forces between the Skyrme solitons.Comment: 27 pages amslate

Incorporating Topography into Landscape Continuity Analysis – Hong Kong Island as a Case Study

published_or_final_versio

Charmless Three-body Decays of B Mesons

Charmless 3-body decays of B mesons are studied in the framework of the factorization approach. The nonresonant contributions arising from $B\to P_1P_2$ transitions are evaluated using heavy meson chiral perturbation theory (HMChPT). The momentum dependence of nonresonant amplitudes is assumed to be in the exponential form e^{-\alpha_{NR}} p_B\cdot(p_i+p_j)} so that the HMChPT results are recovered in the soft meson limit $p_i, p_j\to 0$. In addition, we have identified another large source of the nonresonant signal in the matrix elements of scalar densities, e.g. $$, which can be constrained from the decay $\bar B^0\to K_SK_SK_S$ or $B^-\to K^-K_SK_S$. The intermediate vector meson contributions to 3-body decays are identified through the vector current, while the scalar meson resonances are mainly associated with the scalar density. Their effects are described in terms of the Breit-Wigner formalism. Our main results are: (i) All KKK modes are dominated by the nonresonant background. The predicted branching ratios of $K^+K^-K_{S(L)}$, $K^+K^-K^-$ and $K^-K_SK_S$ modes are consistent with the data within errors. (ii) Although the penguin-dominated $B^0\to K^+K^-K_{S}$ decay is subject to a potentially significant tree pollution, its effective $\sin 2\beta$ is very similar to that of the $K_SK_SK_S$ mode. However, direct CP asymmetry of the former, being of order -4%, is more prominent than the latter. (iii) For $B\to K\pi\pi$ decays, we found sizable nonresonant contributions in $K^-\pi^+\pi^-$ and $\bar K^0\pi^+\pi^-$ modes, in agreement with the Belle measurements but larger than the BaBar result.Comment: 39 pages, 2 figures, version to appear in PR

Beyond Speculative Robot Ethics

In this article we develop a dialogue model for robot technology experts and designated users to discuss visions on the future of robotics in long-term care. Our vision assessment study aims for more distinguished and more informed visions on future robots. Surprisingly, our experiment also lead to some promising co-designed robot concepts in which jointly articulated moral guidelines are embedded. With our model we think to have designed an interesting response on a recent call for a less speculative ethics of technology by encouraging discussions about the quality of positive and negative visions on the future of robotics.

Thin Ice Lithospheres and High Heat Flows on Europa From Large Impact Structure Ring-graben

Craters are probes of planetary surface and interior properties. Here we measure depths, widths, and spacing of circumferential ring-graben surrounding the two largest multiring impact structures on Europa, Tyre and Callanish. We estimate formation conditions including the ice shell structure. The radial extension necessary to form these graben is thought to be caused by asthenospheric drag of warmer, more ductile ice and/or water flowing toward the excavated center of the crater, under a brittle-elastic lithospheric lid. Measurements of graben depths from stereo-photoclinometric digital elevation models result in estimates of displacement, strain, and stress experienced by the ice shell. Graben widths are used to estimate the intersection depth of the bounding normal faults, a quantity related to the brittle-ductile transition depth that approximates elastic shell thickness during crater collapse. Heat flows at the time of crater formation as well as ice lithosphere and total shell thickness are thus also constrained. Average widths and depths tend to decrease with increasing distance from the structure center, while inter-graben spacing generally increases. Varied assumptions yield plausible total conductive ice shell thickness estimates between 4-8 and 2.5-5 km for Tyre and Callanish, respectively, and heat flows of ~70-115 (+/-30) mW m^-2 for realistic thermal conductivities, consistent with other geophysical estimates for Europa. Higher heat flows are consistent with thin (<10 km), conductive ice shells and impact breaching, or penetration of the stagnant lid for a convecting ice shell. Callanish, geologically younger, formed in a time or region of greater heat flow than Tyre.Comment: 50 pages, 18 figures, 2 tables, published in JGR-Planet

How do liquids confined at the nanoscale influence adhesion?

Liquids play an important role in adhesion and sliding friction. They behave as lubricants in human bodies especially in the joints. However, in many biological attachment systems they acts like adhesives, e.g. facilitating insects to move on ceilings or vertical walls. Here we use molecular dynamics to study how liquids confined at the nanoscale influence the adhesion between solid bodies with smooth and rough surfaces. We show that a monolayer of liquid may strongly affect the adhesion.Comment: 5 pages, 9 color figures. Some figures are in Postscript Level 3 format. Minimal changes with respect to the previous version. Added doi and reference to the published article also inside the pape

A Rare Case of Diffuse Polyarthritis in the Context of an Epididymoorchitis due to Mumps Infection

Mumps is a childhood disease with declining incidence in the western world and arthritis is a rare complication associated to the disease. Various presentations exist making diagnosis even more challenging. The mechanisms responsible for the joint involvement remain largely unknown but the timing of onset of the symptoms usually coincide with the rise in antibody titers arguing for an immunologic mediated response. We hereby report a rare case of polyarthritis in the onset of epididymoorchitis due to mumps infection in a HIV infected male patient. Elevated IL-6 serum level in our patient suggests that this cytokine may be an interesting biomarker for the diagnosis of mumps related arthritis

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

PURPOSE: Interleukin-6 (IL-6) levels discriminate between patients with mild and severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a systematic review, meta-analysis, trial sequential analysis (TSA), and meta-regression of randomized-controlled trials to ascertain the benefit of IL-6 blockade with tocilizumab for COVID-19. METHODS: We included randomized-controlled trials (RCTs) allocating patients with COVID-19 to tocilizumab. Our control group included standard care or placebo. Trials co-administering other pharmacological interventions for COVID-19 were not excluded. Primary outcome was 28–30 day mortality. Secondary outcomes included progression-to-severe disease defined as need for mechanical ventilation, intensive-care unit (ICU) admission, or a composite. RESULTS: We identified 10 RCTs using tocilizumab, 9 of which reported primary outcome data (mortality), recruiting 6493 patients with 3358 (52.2%) allocated to tocilizumab. Tocilizumab may be associated with an improvement in mortality (24.4% vs. 29.0%; OR 0.87 [0.74–1.01]; p = 0.07; I2 = 10%; TSA adjusted CI 0.66–1.14). Meta-regression suggested a relationship between treatment effect and mortality risk, with benefit at higher levels of risk (logOR vs %risk beta = −0.018 [−0.037 to −0.002]; p = 0.07). Tocilizumab did reduce the need for mechanical ventilation and was associated with a benefit in the composite secondary outcome but did not reduce ICU admission. CONCLUSIONS: For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required. Its benefits may also lie in reducing the need for mechanical ventilation