The HPV cellular transactivator Brn-3a can be used to predict cervical adenocarcinoma and squamous carcinoma precancer lesions in the developed and developing worlds

The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA. In this study, we show that common and rare cervical precancer lesions, including those of adenocarcinoma (AC), which are usually difficult to diagnose using classical procedures, also expressed high levels of Brn-3a and can be diagnosed by measuring the levels of Brn-3a and E6 mRNAs

A predictor-corrector scheme for vortex identification

A new algorithm for identifying and characterizing vortices in complex flows is presented. The scheme uses both the vorticity and pressure fields. A skeleton line along the center of a vortex is produced by a two-step predictor-corrector scheme. The technique uses the vector field to move in the direction of the skeleton line and the scalar field to correct the location in the plane perpendicular to the skeleton line. A general vortex cross section can be concisely defined with five parameters at each point along the skeleton line. The details of the method and examples of its use are discussed

Adapting to Changes in Design Requirements Using Set‐Based Design

Ship design is a highly intensive and complex process mainly due to the large number of components and competing requirements. With advancement in technology, design, and evaluation processes, more emphasis has been placed on obtaining not just a feasible design, but also an optimal one. Advanced design methods such as set‐based design (SBD) can provide a structured approach to evaluating the design space in order to make accurate and informed decisions toward a more globally optimal design. This paper presents the general application of the SBD process for US Naval vessels as well as a specialized focus on changes in design requirements. Specifically, the two main objectives are an evaluation of how delaying decisions using SBD could cause higher adaptability to changes later in the design process and development of a tradeoff space for evaluating reduced sets. A design experiment that simulated cycles of the SBD process was developed and implemented to provide insight into this objective. The different stages of the experiment included determining intersections between design components in the design space, narrowing variable sets to eliminate infeasible regions, and evaluating the effects of changing design requirements.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90342/1/j.1559-3584.2011.00331.x.pd