7 research outputs found
T2D prediction, glycemic genetic score.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
- Publication date
- Field of study
<p>Forest plot of association between glycemic genetic score with incident T2D over a decade-long follow-up period, by ancestry. MESA (European and Asian ancestry) and the <i>G6PD</i> variant (rs1050828) in ARIC (European and African American) were not included in the discovery GWAS analysis. Effect estimates were combined in a fixed effects meta-analysis. Overall effect estimate: 1.05, 95% CI 1.04–1.06, <i>p</i> = 2.5 × 10<sup>−29</sup>. ARIC, Atherosclerosis Risk in Communities Study; ES, Effect Size; FHS, Framingham Heart Study; GWAS, genome-wide association study; G6PD, glucose-6-phosphate dehydrogenase; I-Squared, Higgin's I-squared statistic, a measure of heterogeneity; MESA, Multiethnic Study of Atherosclerosis; SCHS, Singapore Chinese Health Study; T2D, type 2 diabetes.</p
Manhattan plot of HbA1c associated variants.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
- Publication date
- Field of study
<p>Manhattan plot of the transethnic meta-analysis results in MANTRA. The dashed grey line indicates log<sub>10</sub>BF = 6. Grey and green points denote known/novel loci, respectively. The lead HbA1c-associated variants identified through the ancestry-specific/transethnic analyses are circled in purple (the <i>G6PD</i> variant was not included in the MANTRA analysis, but the locus on the X-chromosome is indicated in the figure). Lines joining the plot & SNP number denote known loci (black), novel loci (green), and loci with a secondary distinct signal (red). MANTRA, Meta-Analysis of Transethnic Association.</p
Reclassification of individuals with discordant T2D status based on prevailing diagnostic thresholds for FG and HbA1c before and after accounting for the effect of erythrocytic variants.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
- Publication date
- Field of study
<p>Reclassification of individuals with discordant T2D status based on prevailing diagnostic thresholds for FG and HbA1c before and after accounting for the effect of erythrocytic variants.</p
Mean HbA1c of individuals at the bottom 5% and top 5% of the distribution of ancestry-specific genetic scores and rs1050828 by genotype.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
- Publication date
- Field of study
<p>The difference in measured HbA1c of individuals at the bottom 5% and top 5% of the distribution of an ancestry-specific additive GS composed of all 60 variants (GS-Total), and the equivalent calculation for an ancestry-specific GS composed of up to 20 erythrocytic variants (GS-E). Far right of the figure shows the mean HbA1c by genotype for chromosome X rs1050828. AA men, African American men; AA women, African American women; HbA1c, glycated hemoglobin; GS, genetic scores.</p
T2D prediction, erythrocytic genetic score.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
- Publication date
- Field of study
<p>Forest plot of association between erythrocytic genetic score with incident T2D over a decade-long follow-up period, by ancestry. MESA (European and Asian ancestry) and the <i>G6PD</i> variant (rs1050828) in ARIC (European and African American) were not included in the discovery GWAS analysis. Effect estimates were combined in a fixed effects meta-analysis. Overall effect estimate: 1.00, 95% CI 0.99–1.01, <i>p</i> = 0.60. ARIC, Atherosclerosis Risk in Communities Study; ES, Effect Size, FHS, Framingham Heart Study; GWAS, genome-wide association study; G6PD, glucose-6-phosphate dehydrogenase; I-Squared, Higgin's I-squared statistic, a measure of heterogeneity; MESA, Multiethnic Study of Atherosclerosis; SCHS, Singapore Chinese Health Study; T2D, type 2 diabetes.</p
Table of HbA1c associated variants.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
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- Field of study
<p>Table with results and classification of the 60 HbA1c-associated variants. SNP number corresponds to number in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002383#pmed.1002383.g001" target="_blank">Fig 1</a>.</p
T2D prediction, erythrocytic genetic score adjusted for HbA1c as a binary variable.
- Author
- Aaron Leong (430710)
- Alain G. Bertoni (820227)
- Alan B. Zonderman (178692)
- Albertine J. Oldehinkel (306724)
- Amelie Bonnefond (4429690)
- Anders Hamsten (62728)
- Andrew P. Morris (145709)
- Andrew Wong (256256)
- Anke Tönjes (103703)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antje Körner (102789)
- Antonella Mulas (145739)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aroon D. Hingorani (142610)
- Audrey Y. Chu (174895)
- Behrooz Z. Alizadeh (93157)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bianca C. Porneala (4429693)
- Bong-Jo Kim (2818132)
- Bruce H. R. Wolffenbuttel (160036)
- Carola Marzi (236979)
- Caroline Hayward (149856)
- Catharina A. Hartman (590692)
- Cathy E. Elks (248352)
- Cecile Lecoeur (4429696)
- Chao Agnes Hsiung (244384)
- Charumathi Sabanayagam (690608)
- Chew-Kiat Heng (429539)
- Chiea-Chuen Khor (159336)
- Chien-Hsiun Chen (28863)
- Ching-Ti Liu (100170)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christian Herder (44905)
- Claes Ladenvall (135128)
- Clara Podmore (2826824)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Daniel I. Chasman (120866)
- Daniel O. Stram (89926)
- Daniel S. Evans (230365)
- Danish Saleheen (181959)
- David J. Roberts (178901)
- David S. Siscovick (174822)
- Denis V. Rybin (4429714)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Dörte Radke (64204)
- E-Shyong Tai (172172)
- Eco J. C. de Geus (109745)
- Edmond K. Kabagambe (127046)
- Eleanor Wheeler (28941)
- Elizabeth Selvin (27362)
- Erik Ingelsson (232651)
- Erik P. A. van Iperen (113549)
- Erwin P. Bottinger (3212694)
- Francesco Cucca (145742)
- Franco Giulianini (175060)
- Fumihiko Takeuchi (118220)
- G. Kees Hovingh (140816)
- Gabriele Müller (373622)
- Goncalo Abecasis (3159045)
- Gonneke Willemsen (75573)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Huaixing Li (36036)
- Hugh Watkins (62729)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Inês Barroso (2144)
- Iva Miljkovic (150145)
- Jaakko Tuomilehto (65635)
- Jaeyoung Hong (4429708)
- James B. Meigs (160696)
- James F. Wilson (150146)
- James G. Wilson (113688)
- James S. Pankow (174656)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jaspal S. Kooner (163553)
- Jer-Yuarn Wu (92059)
- Jerome I. Rotter (103729)
- Jian'an Luan (2145)
- Jian-Min Yuan (145459)
- Jianjun Liu (28194)
- Jie Huang (104235)
- Jie Yao (1440151)
- Johanna Kuusisto (197767)
- John C. Chambers (163544)
- Jose C. Florez (114792)
- Josephine Egan (4429726)
- Josée Dupuis (28859)
- Jouke-Jan Hottenga (75574)
- Juha Saltevo (802585)
- Juyoung Lee (410330)
- Katsuhiko Kohara (344612)
- Ken K. Ong (188600)
- Kent D. Taylor (123459)
- Konstantin Strauch (73658)
- Laura Rasmussen-Torvik (3473966)
- Leif Groop (12005)
- Li-Ching Chang (230873)
- Liang Sun (92795)
- Loic Yengo (3247704)
- Luigi Ferrucci (150038)
- Lynda M. Rose (225264)
- Man Li (81239)
- Manuel Serrano RÃos (2742046)
- Marcus E. Kleber (106276)
- Maria Teresa Martinez Larrad (198681)
- Marie-France Hivert (174606)
- Mark A. Pereira (237312)
- Mark I. McCarthy (145748)
- Mark O. Goodarzi (123440)
- Markku Laakso (197777)
- Martina Müller-Nurasyid (193464)
- Masato Isono (118223)
- Matthias Blüher (103713)
- Matthias Nauck (112743)
- Meena Kumari (95278)
- Michael Boehnke (145750)
- Michael Roden (73251)
- Michael Stumvoll (103716)
- Michele K. Evans (27920)
- Michele Sale (4429723)
- Michiya Igase (344616)
- Mika Kivimaki (2222011)
- Mike A. Nalls (279343)
- Min Jin Go (241897)
- Morris Swertz (383290)
- Myriam Fornage (45591)
- Myron D. Gross (237318)
- Nancy L. Pedersen (123123)
- Neil R. Robertson (686613)
- Nicholas J. Wareham (110277)
- Nicole Soranzo (12361)
- Nisa M. Maruthur (743692)
- Norihiro Kato (118256)
- Olga D. Carlson (48790)
- Ozren Polasek (3965693)
- Panos Deloukas (21564)
- Patrik K. E. Magnusson (123143)
- Pau Navarro (160568)
- Paul M. Ridker (191917)
- Paula S. Ramos (192851)
- Peng Chen (6514)
- Perttu Salo (177200)
- Peter EH. Schwarz (4429720)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Philippe Froguel (2247)
- Qiao Fan (159308)
- Ramaiah Nagaraja (2394)
- Rob M. van Dam (225283)
- Robert A. Scott (160581)
- Robert Sladek (20278)
- Rona J. Strawbridge (419006)
- Ronan Roussel (101806)
- Ruth J. F. Loos (110224)
- Saima Afaq (614013)
- Salman M. Tajuddin (671021)
- Sanghoon Moon (3433241)
- Serena Sanna (145737)
- Shu Pei Tan (4429732)
- Sing-Hui Lim (4429705)
- Stavroula Kanoni (160847)
- Stefan R. Bornstein (114705)
- Stephane Lobbens (4429699)
- Stephen J. Sharp (198654)
- Stephen S. Rich (110262)
- Tamara B. Harris (110195)
- Tetsuro Miki (344617)
- Thomas Meitinger (26605)
- Tien Yin Wong (417969)
- Timothy D. Spector (110281)
- Tin Aung (103674)
- Tom Wilsgaard (321883)
- Tomohiro Katsuya (118243)
- Toshiko Tanaka (174638)
- Valeriya Lyssenko (11998)
- W. Timothy Garvey (113627)
- Wanting Zhao (151459)
- Wayne H. H. Sheu (4429717)
- Wei-Min Chen (110472)
- Weihua Zhang (44940)
- Wen-Jane Lee (392543)
- Wieland Kiess (102793)
- William R. Scott (391938)
- Winfried März (106288)
- Wolfgang Rathmann (107976)
- Woon-Puay Koh (145456)
- Xiuqing Guo (73591)
- Xu Lin (36043)
- Xu Wang (28596)
- Xueling Sim (103662)
- Yao Hu (3479972)
- Yasuharu Tabara (344614)
- Yduan-Tsong Chen (4429735)
- Yechiel Friedlander (211846)
- Yih Chung Tham (4429729)
- Yii-Der Ida Chen (113593)
- Yik-Ying Teo (159446)
- Yingchang Lu (149264)
- Yongmei Liu (104713)
- Yoon Shin Cho (207333)
- Young Jin Kim (207337)
- Yuan Shi (347224)
- Yucheng Jia (4429711)
- Yvonne Böttcher (103725)
- Publication venue
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- Field of study
<p>Forest plot of association between erythrocytic genetic score with incident T2D over a decade-long follow-up period adjusted for HbA1c as a binary variable (≥5.7% versus <5.7%), by ancestry. HbA1c at baseline was not available in SCHS and was excluded from the meta-analysis. MESA (European and Asian ancestry) and the <i>G6PD</i> variant (rs1050828) in ARIC (European and African American) were not included in the discovery GWAS analysis. Effect estimates were combined in a fixed effects meta-analysis. Overall effect estimate: 0.95, 95% CI 0.94–0.96, <i>p</i> = 3.3 × 10<sup>−16</sup>. ARIC, Atherosclerosis Risk in Communities Study; ES, Effect Size; GWAS, genome-wide association study; FHS, Framingham Heart Study; G6PD, glucose-6-phosphate dehydrogenase; HbA1c, glycated hemoglobin; I-Squared, Higgin's I-squared statistic, a measure of heterogeneity; MESA, multiethnic study of atherosclerosis; SCHS, Singapore Chinese Health Study; T2D, type 2 diabetes.</p