56 research outputs found
Quantum-state transfer via resonant tunnelling through local field induced barriers
Efficient quantum-state transfer is achieved in a uniformly coupled spin-1/2
chain, with open boundaries, by application of local magnetic fields on the
second and last-but-one spins, respectively. These effective \textit{barriers}
induce appearance of two eigenstates, bi-localized at the edges of the chain,
which allow a high quality transfer also at relatively long distances. The same
mechanism may be used to send an entire e-bit (e.g., an entangled qubit pair)
from one to the other end of the chain
Low dose of Rotigotine in post-stroke patients with vascular parkinsonism and obstructive sleep apnoea syndrome, effects on quality of life and rehabilitation therapy
Stroke is a frequent cause of disability in U.S.A. (200.000/ year). Aim: The aim of this study is to underline the effect of low dose of Rotigotine patches 2 mg/24 h, a complete dopamine agonist with continuous dopaminergic stimulation through the transdermal administration, in elderly with recent stroke and vascular Parkinsonism about quality of life and adherence to rehabilitation therapy. Methods: We have enrolled 6 elderly patients (3 males and 3 females, range age 60 – 95 years) with recent ischemic and vascular Parkinsonism. We have evaluated quality of life and cognitive function with UPDRS part III, MMSE, ADL, IADL and Morinsky Scale. At the same time we have evaluated the adherence to therapy and timing of rehabilitation therapy before and post-administration of Rotigotine 2 mg/24 hours. Conclusion: In conclusion, Rotigotine could be a new useful approach in the treatment of elderly patients with recent ischemic and hemorrhagic stroke correlated with vascular Parkinsonism which can lead to an akinesia with the need to start rehabilitation therapy. Our preliminary data gives comfortable results but, at this time, we have enrolled only few patients to give conclusive results
DETERMINAZIONE INNOVATIVA DEL ROTENONE NEGLI OLI DI OLIVA DA AGRICOLTURA BIOLOGICA MEDIANTE SPETTROMETRIA DI MASSA TANDEM
Il rotenone, pesticida naturale utilizzato in agricoltura biologica su una grande varietà di colture, è stato determinato quantitativamente mediante Atmosheric Pressure Chemical Ionisation Spettrometria di Massa Tandem (APCI MS/MS) nelle olive e negli oli di oliva ottenuti dopo trattamento in una prova di campo che ha interessato la cv Carolea in Calabria. La tecnica analitica ha previsto la realizzazione di esperimenti “Multiple Reaction Monitoring” (MRM) utilizzando uno standard interno ottenuto per sintesi. Le quantità rilevate sono comprese tra 9 mg/Kg di olio dopo 1 giorno dal trattamento e 0.15 mg/Kg di olio dopo 1 mese circa dal trattamento. Quest’ultimo valore è molto più elevato dei 40 µg/Kg permessi dalla legislazione italiana
Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
Here, we show that a 2:1 mixture of Brutieridin and Melitidin, termed “BMF”, has a statin-like properties, which
blocks the action of the rate-limiting enzyme for mevalonate biosynthesis, namely HMGR (3-hydroxy-3-methylglutaryl-
CoA-reductase). Moreover, our results indicate that BMF functionally inhibits several key characteristics
of CSCs. More specifically, BMF effectively i) reduced ALDH activity, ii) blocked mammosphere
formation and iii) inhibited the activation of CSC-associated signalling pathways (STAT1/3, Notch and Wnt/
beta-catenin) targeting Rho-GDI-signalling. In addition, BMF metabolically inhibited mitochondrial respiration
(OXPHOS) and fatty acid oxidation (FAO). Importantly, BMF did not show the same toxic side-effects in normal
fibroblasts that were observed with statins. Lastly, we show that high expression of the mRNA species encoding
HMGR is associated with poor clinical outcome in breast cancer patients, providing a potential companion
diagnostic for BMF-directed personalized therapy
Engineering a Spin-Orbit Bandgap in Graphene-Tellurium Heterostructures
Intensive research has focused on harnessing the potential of graphene for
electronic, optoelectronic, and spintronic devices by generating a bandgap at
the Dirac point and enhancing the spin-orbit interaction in the graphene layer.
Proximity to heavy p elements is a promising approach; however, their
interaction in graphene heterostructures has not been as intensively studied as
that of ferromagnetic, noble, or heavy d metals, neither as interlayers nor as
substrates. In this study, the effective intercalation of Te atoms in a
graphene on Ir(111) heterostructure is achieved. Combining techniques such as
low energy electron diffraction and scanning tunneling microscopy, the
structural evolution of the system as a function of the Te coverage is
elucidated, uncovering up to two distinct phases. The presented angle-resolved
photoemission spectroscopy analysis reveals the emergence of a bandgap of about
240 meV in the Dirac cone at room temperature, which preserves its
characteristic linear dispersion. Furthermore, a pronounced n-doping effect
induced by Te in the heterostructure is also observed, and remarkably the
possibility of tuning the Dirac point energy towards the Fermi level by
reducing the Te coverage while maintaining the open bandgap is demonstrated.
Spin-resolved measurements unveil a non-planar chiral spin texture with
significant splitting values for both in-plane and out-of-plane spin
components. These experimental findings are consistent with the development of
a quantum spin Hall phase, where a Te-enhanced intrinsic spin orbit coupling in
graphene surpasses the Rashba one and promotes the opening of the spin-orbit
bandgap.Comment: 9 pages, 4 figure
Redox processes of Ruthenium(II) Polypyridine complexes induced by Fast Atom Bombardment Mass Spectrometry
Many-qubit quantum state transfer via spin chains
The transfer of an unknown quantum state, from a sender to a receiver, is one of the main requirements to perform quantum information processing (QIP) tasks. In this respect, the state transfer of a single qubit by means of spin chains has been widely discussed, and many protocols aiming at performing this task have been proposed. Nevertheless, the state transfer of more than one qubit has not been properly addressed so far. In this paper, we present a modified version of a recently proposed quantum state transfer (QST) protocol (Lorenzo S, Apollaro T J G, Sindona A and Plastina F 2013 Phys. Rev. A 87 042313) to obtain a quantum channel for the transfer of two qubits. This goal is achieved by exploiting Rabi-like oscillations due to excitations induced by means of strong and localized magnetic fields. We derive exact analytical formulae for the fidelity of the QST and obtain a high-quality transfer for general quantum states as well as for specific classes of states relevant for QIP
Mechanics of cell wall remodelling in mycobacterium tuberculosis
Dottorato di Ricerca in Organic Materials of Pharmacological Interest, Ciclo XXV, a.a. 2012UniversitĂ degli Studi della Calabri
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