Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Assessing the strength of reinforced concrete structures through Ultrasonic Pulse Velocity and Schmidt Rebound Hammer tests

The experimental studies using Ultrasonic Pulse Velocity and Schmidt Rebound Hammer as Non-Destructive Tests (NDT) were presented in this paper to establish a correlation between the compressive strengths of compression tests and NDT values. These two tests have been used to determine the concrete quality by applying regression analysis models between compressive strength of in-situ concrete on existing building and tests values. The main members of an existing structure including column, beam and slab were included in the study. The relationship between compression strength of concrete collected from crashing test records and estimated results from NDT’s records using regression analysis was compared together to evaluate their prediction for concrete strength. The test results show that the rebound number method was more efficient in predicting the strength of concrete under certain conditions. A combined method for the above two tests, reveals an improvement in the concrete strength estimation and the latter shows better improvement. Applying combined methods produces more reliable results that are closer to the true values. The resulting strength calibration curves estimation was compared with other results from previous published literatures

An experimental study on the effect of cfrp on behavior of reinforce concrete beam column connections

The aim of this research is reinforcing of concrete with variety of fiber reinforced polymer (FRP) configurations and investigates the load capacity and ductility of these connections using an experimental investigation. Six scaled-down RC exterior joints were tested under moderately monotonic loads. The results show that, the shape of the FRP had a different effect on the joint capacity and the connection ductility coefficient. The greatest effect on increasing the ductility factor was seen in the sample where two reinforcement plates were used on both sides of the beam web (RCS5 sample). For the sample with the presence of FRP plates at the top and bottom of the beam (RCS3 sample), the ductility factor was reduced even the load capacity of this sample increased. Except for the RCS3 sample, the rest of the samples exhibited an increase in the ductility factor due to the FRP reinforcement

Behavior of channel shear connectors in normal and light weight aggregate concrete (Experimental and analytical study)

This paper describes five push-out tests carried out at the University of Malaya using channel shear connector. The tests study experimentally and analytically, the behavior of channel shear connectors embedded in normal and light weight aggregate concrete (LWAC). Limited push-out tests are used to measure the accuracy of a proposed nonlinear finite element model for typical push-out test specimens. Using this model, an extensive parametric study performed to arrive at prediction for shear capacity of channel connectors in LWAC. An equation is suggested for the shear capacity of these connectors in LWAC

Gas Injection for Enhancement of Condensate Recovery in a Gas Condensate Reservoir

Gas condensate reservoirs suffer losses in well productivity due to near wellbore condensate dropout when the flowing bottom-hole pressure declines below the dew point pressure. Pressure maintenance and gas cycling are the common practices used in the oil and gas field to alleviate this problem and develop gas condensate reservoirs. The injection of dry gas into a retrograde gas condensate reservoir helps in vaporizing the condensate and increases its dew point. This article investigates the situation of one of the reservoirs located in southern Iran in Zagros area. First, based on the reservoir composition, the phase diagram has been plotted. Peng-Robinson equation of state for the equilibrium calculations and Lee-Kesler characterization of heavy fractions are used in this software. After that the effect of nitrogen, pure methane, a composition of ethane and methane, and carbon dioxide injections on reservoir recovery has been investigated and compared to a natural depletion scheme. The full system, including two separators and a stock tank, are simulated simultaneously and the effect of each type of injection on the liquid and gas production is investigated. Full mixing has been assumed in all of the injections studied. By comparing between the results it is concluded that in an injection process, required injection rate to maintain reservoir pressure above dew point pressure and avoid liquid formation in the reservoir for pure methane, a composition of ethane and methane, pure nitrogen and carbon dioxide, and liquid recovery in all cases are investigated. According to the results, with increasing ethane mole percent in the injecting gas a lower injecting rate for the same liquid recovery is needed. Because with increasing heavy components mole percent in injecting gas, average molecular weight of injecting gas, and reservoir gas becomes closer and there will be a better mixing between them and, therefore, liquid recovery will be improved. Thus, a composition of ethane and methane with more ethane mole percent is better than others. © 2015 Taylor and Francis Group, LLC

Behaviour of C-shaped angle shear connectors under monotonic and fully reversed cyclic loading: An experimental study

This paper presents an evaluation of the structural behaviour of C-shaped angle shear connectors in composite beams, suitable for transferring shear force in composite structures. The results of the experimental programme, including eight push-out tests, are presented and discussed. The results include resistance, strength degradation, ductility, and failure modes of C-shaped angle shear connectors, under monotonic and fully reversed cyclic loading. The results show that connector fracture type of failure was experienced in C-shaped angle connectors and after the failure, more cracking was observed in those slabs with longer angles. On top of that, by comparing the shear resistance of C-shaped angle shear connectors under monotonic and cyclic loading, these connectors showed 8.8-33.1% strength degradation, under fully reversed cyclic loading. Furthermore, it was concluded that the mentioned shear connector shows a proper behaviour, in terms of the ultimate shear capacity, but it does not satisfy the ductility criteria, imposed by the Eurocode 4, to perform a plastic distribution of the shear force between different connectors along the beam length.</p

Comparison of behaviour between channel and angle shear connectors under monotonic and fully reversed cyclic loading

Channel shear connectors are used to transfer longitudinal shear forces through the steel-concrete interface in composite beams. Angle shear connectors without bottom flange compared to channel shear connectors could be cheaper and more economic by saving more steel material. This paper presents an experimental evaluation for comparison of the behaviour of channel and angel shear connectors under monotonic and fully reserved cyclic loading based on 16 push-out tests. The connection shear resistance, ductility and failure modes are presented and discussed. By comparing the channel and angle shear connectors, it was concluded that angle shear connectors showed 7.5-36.4% less shear strength than channel shear connectors under monotonic loading and 23.6-49.2% under fully reversed cyclic loading. Connector's fracture type of failure was experienced for both channel and angle connectors. After the failure, more cracking was observed in slabs with channels compared to slabs with angles. Furthermore, in despite of sufficient ductility for all channel connectors, angle connectors showed less ductility. The results indicate that the angle shear connector gave good behaviour in terms of the ultimate shear capacity; however, this type of connector cannot satisfy the ductility criteria imposed by some codes. In the end, the shear load capacities obtained from the experiments are compared with those suggested by the design codes.</p

Computational and experimental analysis of beam to column joints reinforced with CFRP plates

In this paper, numerical and experimental assessments have been conducted in order to investigate the capability of using CFRP for the seismic capacity improvement and relocation of plastic hinge in reinforced concrete connections. Two scaled down exterior reinforced concrete beam to column connections have been used. These two connections from a strengthened moment frame have been tested under uniformly distributed load before and after optimization. The results of experimental tests have been used to verify the accuracy of numerical modeling using computational ABAQUS software. Application of FRP plate on the web of the beam in connections to improve its capacity is of interest in this paper. Several parametric studies were carried out for CFRP reinforced samples, with different lengths and thicknesses in order to relocate the plastic hinge away from the face of the column