Extraction of ∣Vcd∣|V_{cd}| and ∣Vcs∣|V_{cs}| from experimental decay rates using lattice QCD D→π(K)ℓνD \to \pi(K) \ell \nu form factors

We present a determination of the Cabibbo-Kobayashi-Maskawa matrix elements $|V_{cd}|$ and $|V_{cs}|$ obtained by combining the momentum dependence of the semileptonic vector form factors $f_+^{D \to \pi}(q^2)$ and $f_+^{D \to K}(q^2)$, recently determined from lattice QCD simulations, with the differential rates measured for the semileptonic $D \to \pi \ell \nu$ and $D \to K \ell \nu$ decays. Our analysis is based on the results for the semileptonic form factors produced by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ flavors of dynamical quarks in the whole range of values of the squared 4-momentum transfer accessible in the experiments. The statistical and systematic correlations between the lattice data as well as those present in the experimental data are properly taken into account. With respect to the standard procedure based on the use of only the vector form factor at zero 4-momentum transfer, we obtain more precise and consistent results: $|V_{cd} |= 0.2341 ~ (74)$ and $|V_{cs} |= 0.970 ~ (33)$. The second-row CKM unitarity is fulfilled within the current uncertainties: $|V_{cd}|^2 + |V_{cs}|^2 + |V_{cb}|^2 = 0.996 ~ (64)$. Moreover, using for the first time hadronic inputs determined from first principles, we have calculated the ratio of the semileptonic $D \to \pi(K)$ decay rates into muons and electrons, which represent a test of lepton universality within the SM, obtaining in the isospin-symmetric limit of QCD: ${\cal{R}}_{LU}^{D\pi} = 0.985~(2)$ and ${\cal{R}}_{LU}^{DK} = 0.975~(1)$.Comment: 8 pages, 2 figures, 8 tables. Version to appear in EPJ

Hypercubic effects in semileptonic decays of heavy mesons, toward B→πℓνB \to \pi \ell \nu, with Nf=2+1+1N_f=2+1+1 Twisted fermions

We present a preliminary study toward a lattice determination of the vector and scalar form factors of the $B \to \pi \ell \nu$ semileptonic decays. We compute the form factors relative to the transition between heavy-light pseudoscalar mesons, with masses above the physical D-mass, and the pion. We simulate heavy-quark masses in the range $m_c^{phys} < m_h < 2m_c^{phys}$. Lorentz symmetry breaking due to hypercubic effects is clearly observed in the data, and included in the decomposition of the current matrix elements in terms of additional form factors. We discuss the size of this breaking as the parent-meson mass increases. Our analysis is based on the gauge configurations produced by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ flavors of dynamical quarks at three different values of the lattice spacing and with pion masses as small as $210$ MeV.Comment: 7 pages, 5 figures; contribution to the XXXVI International Symposium on Lattice Field Theory (LATTICE2018), East Lansing (Michigan State University, USA), July 22-28, 201

Masses and decay constants of Bc(∗)B_c^{(*)} mesons with Nf=2+1+1N_f=2+1+1 twisted mass fermions

We present a preliminary lattice determination of the masses and decay constants of the pseudoscalar and vector mesons $B_c$ and $B_c^*$. Our analysis is based on the gauge configurations produced by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ flavors of dynamical quarks. We simulated at three different values of the lattice spacing and with pion masses as small as 210 MeV. Heavy-quark masses are simulated directly on the lattice up to $\sim 3$ times the physical charm mass. The physical b-quark mass is reached using the ETMC ratio method. Our preliminary results are: $M_{B_c} = 6341\,(60)$ MeV, $f_{B_c} = 396\,(12)$ MeV, $M_{B_c^*} / M_{B_c} = 1.0037\,(39)$ and $f_{B_c^*} / f_{B_c} = 0.987\,(7)$.Comment: 7 pages, 3 figures, 1 table; contribution to the proceedings of the XXXVI Int'l Workshop on Lattice Field Theory (LATTICE2018), July 22-28, 2018, East Lansing, Michigan State University (Michigan, USA

Dispersive analysis of the experimental data on the electromagnetic form factor of charged pions at spacelike momenta

The experimental data on the electromagnetic form factor of charged pions available at spacelike momenta are analyzed using the Dispersive Matrix (DM) approach, which describes the momentum dependence of hadronic form factors without introducing any explicit parameterization and includes properly the constraints coming from unitarity and analyticity. The unitary bound is evaluated nonperturbatively making use of the results of lattice QCD simulations of suitable two-point correlation functions contributing to the HVP term of the muon. Thanks to the DM method we determine the pion charge radius from existing spacelike data in a completely model-independent way and consistently with the unitary bound, obtaining $_{DM} = 0.703 \pm 0.027$ fm. This finding differs by $\simeq 1.6$ standard deviations from the latest PDG value $_{PDG} = 0.659 \pm 0.004$ fm, which is dominated by the very precise results of dispersive analyses of timelike data coming from measurements of the cross section of the $e^+ e^- \to \pi^+ \pi^-$ process. We have analyzed the spacelike data using also traditional $z$-expansions, like the Boyd-Grinstein-Lebed (BGL) or Bourrely-Caprini-Lellouch (BCL) fitting functions and adopting a simple procedure that incorporates ab initio the non-perturbative unitary bound in the fitting process. We get $_{BGL} = 0.711 \pm 0.039$ fm and $_{BCL} = 0.709 \pm 0.028$ fm in nice agreement with the DM result. We have addressed also the issue of the onset of perturbative QCD by performing a sensitivity study of the pion form factor at large spacelike momenta, based only on experimental spacelike data and unitarity. Hence, although the leading pQCD behaviour is found to set in only at very large momenta, our DM bands may provide information about the pre-asymptotic effects related to the scale dependence of the pion distribution amplitude.Comment: 39 pages, 21 figures, 4 table

Angular momentum exchange between coherent light and matter fields

Full, three dimensional, time-dependent simulations are presented demonstrating the quantized transfer of angular momentum to a Bose-Einstein condensate from a laser carrying orbital angular momentum in a Laguerre-Gaussian mode. The process is described in terms of coherent Bragg scattering of atoms from a chiral optical lattice. The transfer efficiency and the angular momentum content of the output coupled vortex state are analyzed and compared with a recent experiment.Comment: 4 pages, 4 figure

Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response