How we treat bleeding associated with direct oral anticoagulants

Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the case of bleeding or emergency situations such as trauma, stroke requiring thrombolysis, and urgent surgery. The progressive development of antidotes for these new drugs, which, it is hoped, will become available in the near future, will allow better and safer management of the rapid reversal of their anticoagulant effect

Zika virus and the never-ending story of emerging pathogens and transfusion medicine

In the last few years, the transfusion medicine community has been paying special attention to emerging vector-borne diseases transmitted by arboviruses. Zika virus is the latest of these pathogens and is responsible for major outbreaks in Africa, Asia and, more recently, in previously infection-naïve territories of the Pacific area. Many issues regarding this emerging pathogen remain unclear and require further investigation. National health authorities have adopted different prevention strategies. The aim of this review article is to discuss the currently available, though limited, information and the potential impact of this virus on transfusion medicine

Metabolic and vascular effect of the mediterranean diet

Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic risk factors to increased risk of chronic degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with a lower degree of inflammation biomarkers and with a protective role on cardiovascular and cerebrovascular events. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. Recently, it has been reported a novel positive association between baseline plasma ceramide concentrations and cardiovascular events and how adherence to a Mediterranean Diet-style may influence the potential negative relationship between elevated plasma ceramide concentrations and cardiovascular diseases (CVD). Several randomized controlled trials (RCTs) showed the positive effects of the MeDi diet style on several cardiovascular risk factors, such as body mass index, waist circumference, blood lipids, blood pressure, inflammatory markers and adhesion molecules, and diabetes and how these advantages of the MeDi are maintained in comparison of a low-fat diet. Some studies reported a positive effect of adherence to a Mediterranean Diet and heart failure incidence, whereas some recent studies, such as the PREDIMED study, showed that the incidence of major cardiovascular events was lower among those assigned to MeDi supplemented with extra-virgin olive oil or nuts than among those assigned to a reduced-fat diet. New studies are needed to better understand the molecular mechanisms, whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases, but also discussing other related diseases. We review MedDiet composition and assessment as well as the latest advances in the genomic, epigenomic (DNA methylation, histone modifications, microRNAs, and other emerging regulators), transcriptomic (selected genes and whole transcriptome), and metabolomic and metagenomic aspects of the MedDiet effects (as a whole and for its most typical food components). We also present a review of the clinical effects of this dietary style underlying the biochemical and molecular effects of the Mediterranean diet. Our purpose is to review the main features of the Mediterranean diet in particular its benefits on human health, underling the anti-inflammatory, anti-oxidant and anti-atherosclerotic effects to which new knowledge about epigenetic and gut-microbiota relationship is recently added

A new data assimilation procedure to develop a debris flow run-out model

Abstract Parameter calibration is one of the most problematic phases of numerical modeling since the choice of parameters affects the model\u2019s reliability as far as the physical problems being studied are concerned. In some cases, laboratory tests or physical models evaluating model parameters cannot be completed and other strategies must be adopted; numerical models reproducing debris flow propagation are one of these. Since scale problems affect the reproduction of real debris flows in the laboratory or specific tests used to determine rheological parameters, calibration is usually carried out by comparing in a subjective way only a few parameters, such as the heights of soil deposits calculated for some sections of the debris flows or the distance traveled by the debris flows using the values detected in situ after an event has occurred. Since no automatic or objective procedure has as yet been produced, this paper presents a numerical procedure based on the application of a statistical algorithm, which makes it possible to define, without ambiguities, the best parameter set. The procedure has been applied to a study case for which digital elevation models of both before and after an important event exist, implicating that a good database for applying the method was available. Its application has uncovered insights to better understand debris flows and related phenomena

Generalized Parton Distributions from Hadronic Observables: Zero Skewness

We propose a physically motivated parametrization for the unpolarized generalized parton distributions. At zero value of the skewness variable, $\zeta$, the parametrization is constrained by simultaneously fitting the experimental data on both the nucleon elastic form factors and the deep inelastic structure functions. A rich phenomenology can be addressed based on this parametrization. In particular, we track the behavior of the average: {\it i)} interparton distances as a function of the momentum fraction, $X$, {\it ii)} $X$ as a function of the four-momentum transfer, $t$; and {\it iii)} the intrinsic transverse momentum $k_\perp$ as a function of $X$. We discuss the extension of our parametrization to $\zeta \neq 0$ where additional constraints are provided by higher moments of the generalized parton distributions obtained from {\it ab initio} lattice QCD calculations.Comment: 42 pages, 21 figure

The management of a blood donor bitten by a snake

The worldwide burden of snakebite is high and venomous snakes are found in many regions of the world and are a threat to public health. In Italy, for instance, viper bites are an infrequent but not negligible event. Although people who have been bitten by a snake rarely wish to donate blood within a "short" time, it is however important to evaluate their eligibility to donate blood or blood components as their donation could be a problem for donor management, especially if a specific policy is not in place. The aim of this manuscript is to summarise the worldwide existing donor deferral policy for snakebites and to provide some indications in order to facilitate decision-making and to guarantee maximum safety for the donors as well as for the recipients

Nucleon Tensor Charge from Exclusive πo\pi^o Electroproduction

Exclusive $\pi^o$ electroproduction from nucleons is suggested for extracting the tensor charge and other quantities related to transversity from experimental data. This process isolates C-parity odd and chiral odd combinations of t-channel exchange quantum numbers. In a hadronic picture it connects the meson production amplitudes to C-odd Regge exchanges with final state interactions. In a description based on partonic degrees of freedom, the helicity structure for this C-odd process relates to the quark helicity flip, or chiral odd generalized parton distributions. This differs markedly from deeply virtual Compton scattering, and both vector meson and charged $\pi$ electroproduction, where the axial charge can enter the amplitudes. Contrarily the tensor charge enters the $\pi^o$ process. The connection through the helicity description of the process to both the partonic and hadronic perspectives is studied and exploited in model calculations to indicate how the tensor charge and other transversity parameters can be related to cross section and spin asymmetry measurements over a broad range of kinematics.Comment: 40 pages, 14 figures Revised text clarifying main points, fixing typos, adding reference