Overall age- and sex-specific prevalence of hypertension, Ogliastra, 2002–2008.

<p>Overall age- and sex-specific prevalence of hypertension, Ogliastra, 2002–2008.</p

Anthropometric and Serological determinants of SBP and DBP in Ogliastra, 2002–2008.

<p>Abbreviations: β, regression coefficient; DBP, diastolic blood pressure; SBP, systolic blood pressure.</p>*<p><i>P</i><0.001;</p>**<p><i>P</i><0.05.</p>a<p>HDL and LDL cholesterol, S-sodium and S-calcium were excluded from the final multiple models because their coefficients were statistically significant only in the simple regression models.</p>b<p>Contribution of single independent variables to the explanation of the dependent variables (partial R²).</p>c<p>Age classes: 18–29, 30–39, 40–49, 50–59, 60–69, 70–79, >80 years.</p

Characteristics of Participants in the Epidemiologic Survey in Ogliastra, Sardinia, 2002–2008.

<p>Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure; SD, standard deviation.</p>*<p><i>P</i><0.0001.</p>a<p><i>P</i> values refer to Pearson Chi-square test comparing frequencies of categorical variables or to t-test comparing mean values of quantitative variables in men and women.</p>b<p>prior cardiovascular diseases include hypertension, TIA, stroke, myocardial infarction (ischemic heart disease), heart failure, peripheral vasculopathy or evidence of atherosclerosis.</p>c<p>Test on the equality of standard deviations (variances) in men and women.</p

Mean systolic and diastolic blood pressure by age and sex in the overall sample, Ogliastra, 2002–2008.

<p>Men are represented by blue lines.</p

Heritability estimates of BP measures along with proportion of variance explained by covariates.

<p>Ogliastra, 2002–2008.</p><p>Abbreviations: CI, confidence interval; h², heritability.</p>a<p>The proportion of variance explained by covariates refers to the variables included in the model: sex, age, BMI, alcohol consumption, education, smoking and, exercise.</p

Comparative analysis of the 23 non-synonymous substitutions in protein-coding genes inferred in the full set of 30 sequences.

1<p>Non synonymous variants are bolded. For positions in which only synonymous variants are known italics is used;</p>2<p>from ref. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095969#pone.0095969-Pereira2" target="_blank">[22]</a>;</p>3<p>same aminoacid encoded by a different codon in rCRS and goat;</p><p>n.a.  =  not applicable.</p

Median joining network of 30 sequences showing the occurrence of 23 non-synonymous substitutions.

<p>Each circle represents a sequence. Branch length is proportional to the number of mutations. Note that two A11 and two uncharacterized sequences are lumped into single (larger) nodes (see Materials and Methods). The haplogroup or D-loop clade (for Hg A) affiliation of clusters of sequences is shown in large empty characters. Aminoacid replacements are shown beside each branch in their polarized form. The Hg A portion of the network is magnified while the original network is in the inset. A large lozenge indicates the likely position of the root and was added in the drawing to partition three variants peculiar of Hg C. Their polarization was obtained by comparison with <i>C. ibex</i>.</p

Comparative analysis of the substitutions in RNA-coding genes inferred in the full set of 30 sequences.

1<p>Ambiguous alignment.</p

Analysis of MOlecular VAriance after partitioning according to different criteria.

<p>Analysis of MOlecular VAriance after partitioning according to different criteria.</p

Median joining network of 419 haplotypes and an outgroup obtained as described in Materials and Methods.

<p>Branch length is not proportional to mutational steps. Node size is proportional to haplotype frequency. The correspondence between node clusters and clades in the NJ tree is reported. Unclassified sequences are blackened.</p