Baseline descriptive statistics by classes of estimated glomerular filtration rate of the MATISS study, men and women, aged 35-74 years, free of previous cardiovascular diseases.

<p>Sd: standard deviation;p-values refer to ANOVA for continuous variables and to chi-squared test for categoricalvariables;</p>^<p>Estimated glomerular filtration rate (eGFR) by Chronic Kidney Disease Epidemiology Collaboration;</p><p>° Cigs is for cigarettes;</p><p>°° 10-year cardiovascular risk of the CUORE Project based on age, systolic blood pressure, total and HDL cholesterol, diabetes, smoking habit, treatment for hypertension. It is for men and women 35-69 years old;</p>§<p>For men, serum creatinine ≥1.5 mg/dL; for women ≥ 1.3 mg/dL;</p>§§<p><i>Normal</i>: Systolic Blood Pressure (SBP) <u><</u> 120 <i>AND</i> Diastolic Blood pressure (DBP) <u><</u> 80 mmHg, no antihypertensive drug treatment; <i>Prehypertension</i>: SBP 121-139 <i>OR</i> DBP 81-89 mmHg, no antihypertensive drug treatment; <i>Hypertension</i> Stage <i>I</i>: SBP 140-159 <i>OR</i> DBP 90-99 mmHg, no antihypertensive drug treatment; <i>Hypertension</i> Stage <i>II</i>: SBP > 160 <i>OR</i> DBP > 100 mmHg <i>OR</i> antihypertensive drug treatment</p

Follow-up information by gender of the MATISS study, men and women, aged 35-74 years, free of previous cardiovascular diseases.

<p>Follow-up information by gender of the MATISS study, men and women, aged 35-74 years, free of previous cardiovascular diseases.</p

Baseline descriptive statistics of the MATISS study, men and women, aged 35-74 years, free of previous cardiovascular diseases.

<p>Sd: standard deviation;</p>^<p>Estimated glomerular filtration rate (eGFR) by Chronic Kidney Disease Epidemiology Collaboration;</p><p>° Cigs is for cigarettes;</p><p>°° 10-year cardiovascular risk of the CUORE Project based on age, systolic blood pressure, total and HDL cholesterol, diabetes, smoking habit, treatment for hypertension. It is for men and women 35-69 years old;</p>§<p>For men, serum creatinine ≥1.5 mg/dl; for women ≥ 1.3 mg/dl;</p>§§<p><i>Normal</i>: Systolic Blood Pressure (SBP) <u><</u> 120 <i>AND</i> Diastolic Blood pressure (DBP) <u><</u> 80 mmHg, no antihypertensive drug treatment; <i>Prehypertension</i>: SBP 121-139 <i>OR</i> DBP 81-89 mmHg, no antihypertensive drug treatment; <i>Hypertension</i> Stage <i>I</i>: SBP 140-159 <i>OR</i> DBP 90-99 mmHg, no antihypertensive drug treatment; <i>Hypertension</i> Stage <i>II</i>: SBP > 160 <i>OR</i> DBP > 100 mmHg <i>OR</i> antihypertensive drug treatment</p

Cox model hazard ratios for classes of estimated glomerular filtration rate of the MATISS study, men and women, aged 35-74 years, free of previous cardiovascular diseases.

<p>Estimated glomerular filtration rate (eGFR) by Chronic Kidney Disease Epidemiology Collaboration;</p><p>HR: hazard ratios; ^All cause mortality models were adjusted for age, gender, current smoking , fasting glycemia, systolic blood pressure.</p><p>Incident cardiovascular diseases models were adjusted for age, gender, current smoking , fasting glycemia, systolic blood pressure</p>^^<p>All cause mortality models were adjusted for gender, current smoking , fasting glycemia, systolic blood pressure.</p><p>Incident cardiovascular diseases models were adjusted for gender, current smoking , fasting glycemia, systolic blood pressure.</p

Age- and gender-specific incidence rates per 1000 person years for CVD with or without the presence of MetS.

<p>MetS IDF indicates the metabolic syndrome defined according to the International Diabetes Federation criteria; MetS ATP, the metabolic syndrome defined according to the National Cholesterol Eduation Program-Adult Treatment Panel III; and CVD, cardiovascular disease: (A) fatal and nonfatal CHD, (B) fatal and nonfatal stroke, and (C) cardiovascular death. Numbers above each bar indicate events/persons. Comparison of incidence rates between men and women with MetS within each age group using Pearson Chi²-test, <i>P</i><0.05^a, <i>P</i><0.0001^b, and NS indicates non-significance, <i>P</i>>0.05.</p

Frequency of each MetS component according to gender and age group.

<p>MetS indicates the metabolic syndrome; IDF, the International Diabetes Federation; and ATPIII, Adult Treatment Panel III. The men/women ratio is 38639/30455 for all components except for waist circumference (men/women  = 23817/152899) since not all cohorts registered waist circumference. <i>P</i><0.0001 for each MetS component across age groups in men and women separately. Gender differences within each age group, with <i>P</i><0.0001^a, <i>P</i><0.01^b, <i>P</i><0.05^c, NS indicates non-significance, <i>P</i>>0.05, and the dashed line indicates the same level of significance across the age groups.</p

Significance of age, gender, country, and their interactions, for risk of having the metabolic syndrome or its individual components in adjusted logistic regression models.

<p><i>P</i><0.05 indicates a significant interaction term in the logistic regression model.</p><p>Adjusted for age, sex, country, total cholesterol, smoking- and fasting status.</p><p>MetS ATP indicates the metabolic syndrome defined by the National Cholesterol Education Program - Adult Treatment Panel III; and MetS IDF, the metabolic syndrome defined by the International Diabetes Federation.</p><p>Significance of age, gender, country, and their interactions, for risk of having the metabolic syndrome or its individual components in adjusted logistic regression models.</p

Hazard ratio for different definitions of the metabolic syndrome by age category and event type in men and women.

<p>N indicates the number of events; MetS IDF, metabolic syndrome according to the International Diabetes Federation; and MetS ATP, metabolic syndrome according to the National Cholesterol Education Program – Adult Treatment Panel III.</p><p>Cox model adjusted for smoking (yes/no), cholesterol (continuous), and fasting (full/semi/no fasting).</p>a<p>For the total population, the Cox model is adjusted for age, smoking (yes/no), total cholesterol (continuous), and fasting (full/semi/no fasting).</p><p>Hazard ratio for different definitions of the metabolic syndrome by age category and event type in men and women.</p

Frequency of MetS according to gender and age group.

<p>MetS indicates the metabolic syndrome; IDF, the International Diabetes Federation (MetS IDF) criteria and the National Cholesterol Education Program–Adult Treatment Panel III (MetS ATP) criteria. Numbers above each bar indicate total number of persons with MetS/total number of persons in the given age group; All <i>P</i><0.0001 for each of the 4 MetS/gender combination across age groups. Within each age group, <i>P</i><0.0001 between genders, except for MetS ATP in ages 40–49 years (<i>P</i> = 0.57).</p

Distribution of risk factors in men (a) and women (B) according to age group.

<p>Values are expressed as numbers (percentages) or median (5% to 95% percentiles).</p>a<p>Number of subjects  = 39106 (Men/Women  = 23817/15289) since not all cohorts registered waist circumference.</p><p>Comparison of risk factor values between age groups (i.e., 19–39 years versus 40–49 years, 40–49 years versus 50–59 years, and so on) for men and women separately, all <i>P</i><0.0001, except. ^b<i>P</i><0.01, ^c<i>P</i><0.05, and ^d<i>P</i>>0.05.</p><p>Comparison of risk factor values between men and women within each age group, all <i>P</i><0.0001, except for SBP levels in ages 60–78 years, and % of diabetics in ages 19–49 years and ages 60–78 years, where all <i>P</i>>0.05.</p><p>Distribution of risk factors in men (a) and women (B) according to age group.</p