Second Anthropocene Working Group meeting

The second meeting of the Anthropocene Working Group (AWG) was held at the McDonald Institute for Archaeological Research, University of Cambridge, on 24th and 25th November 2015. It took the form of a workshop with 12 members of the working group and numerous archaeologists from the Institute in lively conversation with each other. Discussion was focused on anthropogenic strata and matters of chronostratigraphy. The AWG was set up in 2009 to consider the case for formalizing the term ‘Anthropocene’ in the Geological Time Scale. The working group reports to the Subcommission on Quaternary Stratigraphy, which sits within the broader framework of the International Commission on Stratigraphy (ICS). Unusually for a working group of the ICS, it consists of researchers from a wide variety of Earth Sciences, including archaeology

Origin of the transient unpulsed radio emission from the PSR B1259-63 binary system

We discuss the interpretation of transient, unpulsed radio emission detected from the unique pulsar/Be-star binary system PSR B1259-63. Extensive monitoring of the 1994 and 1997 periastron passages has shown that the source flares over a 100-day interval around periastron, varying on time-scales as short as a day and peaking at 60 mJy (~100 times the apastron flux density) at 1.4 GHz. Interpreting the emission as synchrotron radiation, we show that (i) the observed variations in flux density are too large to be caused by the shock interaction between the pulsar wind and an isotropic, radiatively driven, Be-star wind, and (ii) the radio emitting electrons do not originate from the pulsar wind. We argue instead that the radio electrons originate from the circumstellar disk of the Be star and are accelerated at two epochs, one before and one after periastron, when the pulsar passes through the disk. A simple model incorporating two epochs of impulsive acceleration followed by synchrotron cooling reproduces the essential features of the radio light curve and spectrum and is consistent with the system geometry inferred from pulsed radio data.Comment: To be published in Astrophysical Journal Letters 7 pages, 1 postscript figur

A novel method for the genome-wide high resolution analysis of DNA damage

DNA damage occurs via endogenous and exogenous genotoxic agents and compromises a genome’s integrity. Knowing where damage occurs within a genome is crucial to understanding the repair mechanisms which protect this integrity. This paper describes a new development based on microarray technology which uses ultraviolet light induced DNA damage as a paradigm to determine the position and frequency of DNA damage and its subsequent repair throughout the entire yeast genome

The Health Promoting Schools Framework: Known Unknowns and an Agenda for Future Research.

The World Health Organization's Health Promoting Schools (HPS) framework is a whole-school approach to promoting health that recognizes the intrinsic relationship between health and education. Our recent Cochrane systematic review found HPS interventions produced improvements in a number of student health outcomes. Here we reflect on what this review was not able to tell us: in other words, what evidence is missing with regard to the HPS approach. Few HPS interventions engage with schools' "core business" by examining impacts on educational outcomes. Current evidence is dominated by obesity interventions, with most studies conducted with children rather than adolescents. Evidence is lacking for outcomes such as mental or sexual health, substance use, and violence. Activities to engage families and communities are currently weak and unlikely to prompt behavioral change. The HPS approach is largely absent in low-income settings, despite its potential in meeting children's basic health needs. Intervention theories are insufficiently complex, often ignoring upstream determinants of health. Few studies provide evidence on intervention sustainability or cost-effectiveness, nor in-depth contextual or process data. We set out an agenda for future school health promotion research, considering implications for key stakeholders, namely, national governments, research funders, academics, and schools

Evidence for a stratigraphic basis for the Anthropocene

The Anthropocene was proposed as a term (Crutzen and Stoermer 2000) before consideration was given to the nature of the key signatures, contrasting with standard procedures for defining such units. The term is being widely used in both popular and scientific publications before a decision is made as to whether it warrants formalisation and definition of a Global Stratigraphic Section and Point (GSSP). The deliberate human modification of the landscape and its subsurface, and the creation of human-generated novel sedimentary deposits, minerals, and landforms, are characteristic features of the development of Earth’s surface and near surface, which has accelerated in the past two centuries. The large-scale intentional excavation, transportation, and deposition of mixtures of rock and soil to form anthropogenic deposits and landforms represent a new geological process that could be used as a diagnostic signature of the Anthropocene

The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80

CTLA-4 and PD-1 are key immune checkpoint receptors that are targeted in the treatment of cancer. A recently identified physical interaction between the respective ligands, CD80 and PD-L1, has been shown to block PD-L1/PD-1 binding and to prevent PD-L1 inhibitory functions. Since CTLA-4 is known to capture and degrade its ligands via transendocytosis, we investigated the interplay between CD80 transendocytosis and CD80/PD-L1 interaction. We find that transendocytosis of CD80 results in a time-dependent recovery of PD-L1 availability that correlates with CD80 removal. Moreover, CD80 transendocytosis is highly specific in that only CD80 is internalised, while its heterodimeric PD-L1 partner remains on the plasma membrane of the antigen-presenting cell (APC). CTLA-4 interactions with CD80 do not appear to be inhibited by PD-L1, but efficient removal of CD80 requires an intact CTLA-4 cytoplasmic domain, distinguishing this process from more general trogocytosis and simple CTLA-4 binding to CD80/PD-L1 complexes. These data are consistent with CTLA-4 acting as modulator of PD-L1:PD-1 interactions via control of CD80