Additional file 1: of Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-Îł autoantibodies in adult patients with myositis

Table S1. Immunochip study data included in analyses. Assigned latitude and numbers of PM, DM and controls at each centre included in the study. (DOCX 25 kb

Additional file 2: of Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis

Figure S1. The association of relative dermatomyositis (DM) prevalence, frequency of DM-associated autoantibodies, HLA alleles and single-nucleotide polymorphisms with latitude. Two-way linear prediction plot with 95% CIs was produced using STATA version 13.1 software. Data for DM as a proportion of PM and DM (n = 1769), frequency of anti-TIF1-γ in all samples tested (n = 1345) and frequency of anti-Mi-2 in all samples tested (n = 1471) are derived from the Immunochip study [8]. Frequencies of HLA-DQB1*02, HLA-DRB1*07:01, rs4702698 and rs570676 are derived from the Immunochip control data (n = 9911). (TIF 2203 kb

Asarum megacalyx F. Maekawa

原著和名: コシノカンアフヒ科名: ウマノスズクサ科 = Aristolochiaceae採集地: 新潟県 三島郡 和島村 (越後 和島村)採集日: 1966/4/6採集者: 萩庭丈壽整理番号: JH040926国立科学博物館整理番号: TNS-VS-99092

Cephalotaxus harringtonia K. Koch var. nana Rehd.

原著和名: ハヒイヌガヤ科名: イヌガヤ科 = Cephalotaxaceae採集地: 福島県 甲子山 (岩代 甲子山)採集日: 1969/6/29採集者: 萩庭丈壽整理番号: JH040205国立科学博物館整理番号: TNS-VS-99020

Additional file 3: of Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies

DAPPLE output. Excel file of the output provided by http://www.broadinstitute.org/mpg/dapple/dappleTMP.php from each DAPPLE analysis on SNPs, autoantibody targets, a subset of autoantibody targets and SNPs and autoantibody target subset combined (XLSX 6162 kb

Frequencies of the DLA haplotypes found in Hungarian Vizslas.

<p>Frequencies of the DLA haplotypes found in Hungarian Vizslas.</p

Association of the DLA-DRB1*02001/DQA1*00401/DQB1*01303 genotypes with polymyositis, relative to the disease risk in individuals who are DLA-DRB1*02001/DQA1*00401/DQB1*01303 homozygous negative.

<p>Association of the DLA-DRB1*02001/DQA1*00401/DQB1*01303 genotypes with polymyositis, relative to the disease risk in individuals who are DLA-DRB1*02001/DQA1*00401/DQB1*01303 homozygous negative.</p

Haplotype and homozygous frequency of DLA-DRB1*02001/DQA1*00401/DQB1*01303 in cases and “graded controls”.

<p>Haplotype and homozygous frequency of DLA-DRB1*02001/DQA1*00401/DQB1*01303 in cases and “graded controls”.</p

The criteria used to assign cases to a diagnostic confidence grouping.

<p>The criteria used to assign cases to a diagnostic confidence grouping.</p