The Species Concordance Method of Tide Prediction in Estuaries

The harmonic method of tide prediction is developed to its fullest extent, so that it can deal with tide curves which are so distorted that they have gradient discontinuities. It is better, however, to use a new two-step method known as the method of species concordance. This method is applied to the Gironde, and then to the Loire, where the variation in fresh-water level is important

A macroprolactinoma becoming resistant to cabergoline and developing atypical pathology

Pituitary adenomas are a common intracranial neoplasm, usually demonstrating a benign phenotype. They can be classified according to pathological, radiological or clinical behaviour as typical, atypical or carcinomas, invasive or noninvasive, and aggressive or nonaggressive. Prolactinomas account for 40-60% of all pituitary adenomas, with dopamine agonists representing the first-line treatment and surgery/radiotherapy reserved for drug intolerance/resistance or in neuro-ophthalmological emergencies. We present the case of a 62-year-old man with an apparently indolent prolactin-secreting macroadenoma managed with partial resection and initially showing a biochemical response to cabergoline. Five years later, the tumour became resistant to cabergoline, despite a substantial increase in dosage, showing rapid growth and causing worsening of vision. The patient then underwent two further transsphenoidal operations and continued on high-dose cabergoline; despite these interventions, the tumour continued enlarging and prolactin increased to 107 269 U/L. Histology of the third surgical specimen demonstrated features of aggressive behaviour (atypical adenoma with a high cell proliferation index) not present in the tumour removed at the first operation. Subsequently, he was referred for radiotherapy aiming to control tumour growth

The Transformation of Sediment Into Rock : Insights From IODP Site U1352, Canterbury Basin, New Zealand

ACKNOWLEDGMENTS We thank the crew of the RV JOIDES Resolution for professional seamanship, excellent drilling, and the scientific support on board. GHB and SCG thank the Australia–New Zealand IODP Consortium (ANZIC), and KMM thanks the Consortium for Ocean Leadership U.S. Science Support Program for partly funding this work. Thanks also to funding agencies of the respective authors, and Mark Lawrence (GNS Science) and Cam Nelson (University of Waikato) for their thoughtful comments on an earlier draft. Karsten Kroeger (GNS Science) helped by providing compaction data for New Zealand basins, and Michelle Kominz (Western Michigan University) provided data on which Figure 8 was developed. Further improvements were the result of thoughtful detailed reviews by Gemma Barrie, Bill Heins, Stan Paxton, Associate Editor Joe Macquaker, and Editor Leslie Melim.Peer reviewedPostprin

Big Data Opportunities for Global Infectious Disease Surveillance

Simon Hay and colleagues discuss the potential and challenges of producing continually updated infectious disease risk maps using diverse and large volume data sources such as social media

Crystallization and preliminary X-ray diffraction analysis of two N-terminal fragments of the DNA-cleavage domain of topoisomerase IV from Staphylococcus aureus. Corrigendum

A corrigendum to the paper by Carr et al. (2006), Acta Cryst. F62, 1164–1167

Crystallization and preliminary X-ray diffraction analysis of two N-terminal fragments of the DNA-cleavage domain of topoisomerase IV from Staphylococcus aureus

The crystallization and data collection of topoisomerase IV from S. aureus is described. Phasing by molecular replacement proved difficult owing to the presence of translational NCS and strategies used to overcome this are discussed