Experimental apparatus.

<p>(1) Computer monitor. (2) Circular target indicating the start of the experiment. (3) Cursor. (4) Path of the task: in this case sinusoidal but may also be square or circular. (5) Dome-shaped unseen ‘mouse’ that cancels the effect of tremor. (6) Digitizing tablet.</p

Effect of <i>group</i> and <i>test-order</i> on VMC variables.

<p>Test 1 and Test 2 refer to the first and second testing sessions respectively. Note that a larger score for all these variables with the exception of V_c indicates worse performance. An adjusted significance level of 0.01 according to the Bonferroni correction for 5 non-VMC variables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065270#pone.0065270-Abdi1" target="_blank">[72]</a> was used. Please refer to the text (Methods, Study Design and VMC Testing) for definitions of abbreviations.</p>1<p>A higher score in this variable (in contrast to other variables) indicates an improvement.</p

Univariate testing of <i>hand</i> and <i>path</i> on VMC variables.

1<p>Significance level of 0.01 (Bonferroni correction for 5 variables) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065270#pone.0065270-Abdi1" target="_blank">[72]</a>. Only findings of statistical significance are presented. Please refer to the text (Methods, Study Design and VMC Testing) for definitions of abbreviations.</p

Patient demographics and cognitive tests.

1<p>Pre-operative data was derived from patients’ records.</p>2<p>LDED: levodopa equivalent dose.</p>3<p>Suffix ‘c’ indicates corrected score as calculated by: actual score subtracted from the expected score according to normative data for age group <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065270#pone.0065270-Kave1" target="_blank">[60]</a>. Thus a lower corrected score reflects better performance.</p><p>Please refer to the text (Methods, Study Design and Cognitive Testing) for definitions of abbreviations.</p

Clinical motor function, attention and mood in PD patients.

1<p>Separate MANOVAs were performed for each variable group.</p>2<p>The mean value for both hands is used.</p>3<p>Significance level of 0.007 (Bonferroni correction for 7 non-VMC variables) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065270#pone.0065270-Abdi1" target="_blank">[72]</a>.</p>4<p>The sum of UPDRS items 28–30.</p>5<p>Sad_tired is the arithmetic mean of the scores for sad and tired. The mean was taken because of the high correlation value (see text for explanation).</p