Synthesis of 4‑Arylthieno[2,3‑<i>b</i>]pyridines and 4‑Aminothieno[2,3‑<i>b</i>]pyridines via a Regioselective Bromination of Thieno[2,3‑<i>b</i>]pyridine

The first regioselective, mild bromination of thieno­[2,3-<i>b</i>]­pyridine is described herein. The reaction proceeds with selectivity toward the 4-position (87% isolated yield). Subsequent cross-coupling reactions proceed in excellent yields and demonstrate the potential of 4-bromothieno­[2,3-<i>b</i>]­pyridine as a building block for use in drug discovery research