Királis rendszerek nem lineáris szelektív kölcsönhatásainak vizsgálata = Examination of the selective interactions in nonlinear chiral systems

Nem lineáris szelektív kölcsönhatásait vizsgáltuk a racém vegyületekből kiinduló enantiomerek elkülönítésének folyamataiban, a kölcsönhatások következtében keletkezett diasztereomerek és enantiomerek keverékeinek az elválasztásai során mért adatok (ee, T, S) alapján. Felismertük, hogy a hagyományosan diasztereomer sókat képező reszolválóágensek, alkalmasak arra is, hogy diasztereomer molekulakomplexeket képezzenek alkoholokkal. A foszfor-kiralitáscentrumot tartalmazó gyűrűs vegyületek enantiomer elválasztása eddig nem volt megoldott. Mi borkősav származékokkal (TADDOL, SPIROTADDOL) a racém foszfolén-oxid származékait, diasztereomer molekulakomplexekként eredményesen reszolváltuk. Felfigyeltünk a diasztereomer sók elválasztása során fellépő kinetikus kontroll fontos szerepére. Összefoglalhatjuk, hogy a kutatás főbb területei: racém homológ sorok reszolválása azonos reszolválóágenssel; származék reszolválóágensek alkalmazása; a diasztereomer szerkezeti felépítésének vizsgálata; az oldószer szerepének vizsgálata a reszolválási műveletek során, oldószer nélküli elválasztások; enantiomer keverékek elválasztása olvadékkristályosítással; enentiomer keverékek és származékainak viselkedése a származékok függvényében. A kutatási időszakba 30- túlnyomórészt nemzetközi -folyóiratcikk (melyek közül 2, nagy elismertségnek és olvasottságnak örvendő, review) született. Az eredményeket 10 külföldi és 6 hazai konferencián is bemutattuk. | We examined the non-linear selective interactions of chiral systems in the processes of separation of enantiomers obtained from racemic compounds, based on the measured data (ee, y, S). Is remarkable the fact that the the similarity of molecules has an important effect on enantiomer recognition. (for example, in case of resolution of menthol and neomenthol this effect was remarkable ). The separation of heterocycles compounds including chiral P-atom was not solved. We were able to resolve enantiomers of N-oxides of amino-derivatives based on the similarity of structures. We noticed the effect of the kinetic control on the resolution processes which was not described before. We can summarize the main areas of our project which were the following; the resolution of racemic homologue lines with similar resolving agents; monitoring resolution processes used derivatives of resolving agent, the examination of structure of diastereomer; the examination of the role of solvent in the resolution processes. resolution without solvent, separation of enantiomer mixtures using crystallization from melt, the behaviour of mixtures of ennatiomers and their derivetives as a function of derivatives. In course of the project our results were published in 30 articles (2 reviews, with well read), and they were presented at 10 International- and at 6 National Conferences.international journals, and they were presented at 10 International- and at 6 National Conferences

Potential for Greenhouse Gas Reduction in Industry through Increased Heat Recovery and/or Integration of Combined Heat and Power

The potential for greenhouse gas (GHG) reduction in industry through process integration measures depends to a great extent on prevailing technical and economic conditions. A step-wise methodology developed at the author's department based on pinch technology was used to analyse how various parameters influence the cost-optimal configuration for the plant's energy system, and the opportunities for costeffective GHG emissions reduction compared to this solution. The potential for reduction of GHG emissions from a given plant depends primarily on the design of the industrial process and its energy system (internal factors) and on the electricity-to-fuel price ratio and the specific GHG emissions from the national power generation system (external factors)

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

International audienceAbstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO 2 ) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO 2 with patients’ outcome. Methods Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO 2  300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO 2 -AUC), for hyperoxemia was significantly associated with mortality ( p = 0.003). Conclusions In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration : clinicaltrials.gov NCT02908308 , Registered September 20, 2016

Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

International audienc