Prosocial and antisocial children's perceptions of peers' motives for prosocial behaviours

This study investigated whether peer-nominated prosocial and antisocial children have different perceptions of the motives underlying peers' prosocial actions. Eighty-seven children, aged 10-12 years old, completed peer-nomination measures of social behaviour. On the basis of numbers of social nominations received, a subsample of 51 children (32 who were peer-nominated as 'prosocial', and 18 who were peer-nominated as 'antisocial') then recorded their perceptions of peers' motives for prosocial behaviours. Expressed motives were categorized predominantly into three categories, coinciding with Turiel's (1978) 'moral', 'conventional', and 'personal domains'. Results indicate that children's social reputation is associated with the extent to which they perceive peers' prosocial motives as 'personal' or 'moral', with more prosocial children attributing moral motives, and more antisocial children attributing personal motives. Although traditionally Turiel's domain theory has been used to understand 'antisocial' children's behaviour, the current findings suggest that 'prosocial' children's behaviour may also be related to domains of judgment

Perceptions and correlates of peer-victimization and bullying

The experiences of peer-victimization and bullying are often treated empirically as though they are conceptually indistinct. Both involve repeated aggression,but definitions of bullying additionally emphasize the importance of aggressor intent and imbalance of power between the aggressor and the victim (Olweus, 1978; Whitney & Smith, 1993). The present study aimed to examine the extent to which peer-victimization and bullying are empirically similar. The sample comprised 1,429 pupils (50.2% male) aged between 8 and 13 years attending mainstream Scottish schools. Self-report questionnaire assessing peer-victimization and bullying, copingstrategy use (WCCL: Hunter, 2000), situational appraisal and depressive symptomatology (Birleson, 1981). Almost one-third (30.7%) of pupils reported experiencing peer-victimization, and of these 38.1% (11.7% of whole sample) were categorized as victims of bullying. Victims of bullying perceived higher levels of threat and lower levels of perceived control. They also reported using more Wishful Thinking and Social Support coping strategies, but did not differ on Problem Focused coping. Bullied pupils also reported higher levels of depressive symptomatology. Peer-victimization and bullying appear to be qualitatively different experiences for children and adolescents, with bullying being the more serious phenomenon

On the binary helium star DY Centauri: Chemical composition and evolutionary state

DY Cen has shown a steady fading of its visual light by about 1 magnitude in the last 40 years suggesting a secular increase in its effective temperature. We have conducted non-LTE and LTE abundance analyses to determine the star's effective temperature, surface gravity, and chemical composition using high-resolution spectra obtained over two decades. The derived stellar parameters for three epochs suggest that DY Cen has evolved at a constant luminosity and has become hotter by about 5000 K in 23 years. We show that the derived abundances remain unchanged for the three epochs. The derived abundances of the key elements, including F and Ne, are as observed for the extreme helium stars resulting from a merger of an He white dwarf with a C-O white dwarf. Thus, DY Cen by chemical composition appears to be also a product of a merger of two white dwarfs. This appearance seems to be at odds with the recent suggestion that DY Cen is a single-lined spectroscopic binary.Comment: Accepted to ApJ with 8 Figures and 5 Table

Movements Into and Out of Child Poverty in New Zealand: Results from the Linked Income Supplement

This paper considers the dynamics of child income poverty in New Zealand. Annual movements into and out of poverty by children’s households in New Zealand over the 1997/98, 1998/99, and 1999/2000 periods are analysed. The annual Income Supplement to the Household Labour Force Survey allows tracking of dwellings and people in two consecutive June quarterly weeks, and thus allows observation of changes in equivalised household disposable income over a June year. This project is the first to use the Linked Income Survey for analysis of income dynamics and is part of the Ministry of Social Policy’s ongoing research on family dynamics.New Zealand adult and child poverty transitions are compared. Child poverty transitions in New Zealand are compared and contrasted to those of five other countries—Britain, Germany, Hungary, Russia and Spain—where a similar current income measure of poverty is available. The frequency of poverty “trigger events” in New Zealand and their impact on the chances of children exiting and entering poverty are compared to similar data for Britain and West Germany.child poverty, household income, income mobility

Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak

The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to humans, accounting for the scale of the 2014 outbreak. We computationally analyze the variation associated with all EVD outbreaks, and find none of the amino acid replacements lead to identifiable functional changes. These changes have minimal effect on protein structure, being neither stabilizing nor destabilizing, are not found in regions of the proteins associated with known functions and tend to cluster in poorly constrained regions of proteins, specifically intrinsically disordered regions. We find no evidence that the difference between the current and previous outbreaks is due to evolutionary changes associated with transmission to humans. Instead, epidemiological factors are likely to be responsible for the unprecedented spread of EVD

Movements Into and Out of Child Poverty in New Zealand: Results from the Linked Income Supplement

This paper considers the dynamics of child income poverty in New Zealand. Annual movements into and out of poverty by children's households in New Zealand over the 1997/98, 1998/99, and 1999/2000 periods are analysed. The annual Income Supplement to the Household Labour Force Survey allows tracking of dwellings and people in two consecutive June quarterly weeks, and thus allows observation of changes in equivalised household disposable income over a June year. This project is the first to use the Linked Income Survey for analysis of income dynamics and is part of the Ministry of Social Policy's ongoing research on family dynamics. New Zealand adult and child poverty transitions are compared. Child poverty transitions in New Zealand are compared and contrasted to those of five other countries-Britain, Germany, Hungary, Russia and Spain-where a similar current income measure of poverty is available. The frequency of poverty "trigger events" in New Zealand and their impact on the chances of children exiting and entering poverty are compared to similar data for Britain and West Germany.Child poverty, household income, income mobility

Adaptive HIV-1 evolutionary trajectories are constrained by protein stability

Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations. The involvement of multiple mutations can arise due to interactions between sites in the amino acid sequence as a consequence of the need to maintain protein structure. To better understand the nature of such epistatic interactions, we reconstructed the ancestral sequences of HIV-1's Pol protein, and traced the evolutionary trajectories leading to mutations associated with drug resistance. Using contemporary and ancestral sequences we modelled the effects of mutations (i.e. amino acid replacements) on protein structure to understand the functional effects of residue changes. Although the majority of resistance-associated sequences tend to destabilise the protein structure, we find there is a general tendency for protein stability to decrease across HIV-1's evolutionary history. That a similar pattern is observed in the non-drug resistance lineages indicates that non-resistant mutations, for example, associated with escape from the immune response, also impacts on protein stability. Maintenance of optimal protein structure therefore represents a major constraining factor to the evolution of HIV-1

Absolutely continuous spectrum for a random potential on a tree with strong transverse correlations and large weighted loops

We consider random Schr\"odinger operators on tree graphs and prove absolutely continuous spectrum at small disorder for two models. The first model is the usual binary tree with certain strongly correlated random potentials. These potentials are of interest since for complete correlation they exhibit localization at all disorders. In the second model we change the tree graph by adding all possible edges to the graph inside each sphere, with weights proportional to the number of points in the sphere.Comment: 25 pages, 4 figure

Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys.

These studies focused on a new radiolabeling technique with copper ((64)Cu) and zirconium ((89)Zr) for positron emission tomography (PET) imaging using a CD45 antibody. Synthesis of (64)Cu-CD45 and (89)Zr-CD45 immunoconjugates was performed and the evaluation of the potential toxicity of radiolabeling human peripheral blood stem cells (hPBSC) was assessed in vitro (viability, population doubling times, colony forming units). hPBSC viability was maintained as the dose of (64)Cu-TETA-CD45 increased from 0 (92%) to 160 µCi/mL (76%, p>0.05). Radiolabeling efficiency was not significantly increased with concentrations of (64)Cu-TETA-CD45 >20 µCi/mL (p>0.50). Toxicity affecting both growth and colony formation was observed with hPBSC radiolabeled with ≥40 µCi/mL (p<0.05). For (89)Zr, there were no significant differences in viability (p>0.05), and a trend towards increased radiolabeling efficiency was noted as the dose of (89)Zr-Df-CD45 increased, with a greater level of radiolabeling with 160 µCi/mL compared to 0-40 µCi/mL (p<0.05). A greater than 2,000 fold-increase in the level of (89)Zr-Df-CD45 labeling efficiency was observed when compared to (64)Cu-TETA-CD45. Similar to (64)Cu-TETA-CD45, toxicity was noted when hPBSC were radiolabeled with ≥40 µCi/mL (p<0.05) (growth, colony formation). Taken together, 20 µCi/mL resulted in the highest level of radiolabeling efficiency without altering cell function. Young rhesus monkeys that had been transplanted prenatally with 25×10(6) hPBSC expressing firefly luciferase were assessed with bioluminescence imaging (BLI), then 0.3 mCi of (89)Zr-Df-CD45, which showed the best radiolabeling efficiency, was injected intravenously for PET imaging. Results suggest that (89)Zr-Df-CD45 was able to identify engrafted hPBSC in the same locations identified by BLI, although the background was high