Church planting as evangelism : how people are influenced and worldview assumptions impacting church plants and church multiplication

https://place.asburyseminary.edu/ecommonsatsdissertations/2666/thumbnail.jp

Systems Biology via Redescription and Ontologies (III): Protein Classification using Malaria Parasite’s Temporal Transcriptomic Profiles

This paper addresses the protein classification problem, and explores how its accuracy can be improved by using information from time-course gene expression data. The methods are tested on data from the most deadly species of the parasite responsible for malaria infections, Plasmodium falciparum. Even though a vaccination for Malaria infections has been under intense study for many years, more than half of Plasmodium proteins still remain uncharacterized and therefore are exempted from clinical trials. The task is further complicated by a rapid life cycle of the parasite, thus making precise targeting of the appropriate proteins for vaccination a technical challenge. We propose to integrate protein-protein interactions (PPIs), sequence similarity, metabolic pathway, and gene expression, to produce a suitable set of predicted protein functions for P. falciparum. Further, we treat gene expression data with respect to various changes that occur during the five phases of the intraerythrocytic developmental cycle (IDC) (as determined by our segmentation algorithm) of P. falciparum and show that this analysis yields a significantly improved protein function prediction, e.g., when compared to analysis based on Pearson correlation coefficients seen in the data. The algorithm is able to assign “meaningful ” functions to 628 out of 1439 previously unannotated proteins, which are first-choice candidates for experimental vaccine research.

Hepatocellular Carcinoma in the Woodchuck Model of Hepatitis B Virus Infection

The Eastern woodchuck (Marmota monax) harbors a DNA virus (Woodchuck hepatitis virus [WHV]) that is similar in structure and replicative life cycle to the human hepatitis B virus (HBV). Like HBV, WHV infects the liver and can cause acute and chronic hepatitis. Furthermore, chronic WHV infection in woodchucks usually leads to development of hepatocellular carcinoma (HCC) within the first 2–4 years of life. The woodchuck model has been important in the preclinical evaluation of safety and efficacy of the antiviral drugs now in use for treatment of HBV infection and continues to serve as an important, predictive model for innovative forms of therapy of hepatitis B using antiviral nucleosides and immune response modifiers alone or in combination. Almost all woodchucks that become chronic WHV carriers after experimental neonatal inoculation develop HCC with a median HCC-free survival of 24 months and a median life expectancy of 30–32 months. The woodchuck model of viral induced HCC has been used effectively for the development of new imaging agents for enhancement of detection of hepatic neoplasms by ultrasound and magnetic resonance imaging. The chemoprevention of HCC using long-term antiviral nucleoside therapy has been shown in the woodchuck, and “proof of principal” has been established for some of the innovative, molecular methods for treatment of HCC. The model is available for fundamental investigations of the viral and molecular mechanisms responsible for hepatocarcinogenesis and should have substantial value for future development of innovative methods for chemoprevention and gene therapy of human HCC

CHOOSING THE COMPETITIVE FORMS OF MARKETING MANAGEMENT AS A PART OF ENTERPRISES AND INTEGRATED BUSINESS STRUCTURES STRATEGIC MANAGEMENT ORGANIZATION

Abstract: The theoretical rationale is provided for the development of organizational and structural support for marketing management of an industrial enterprise that functions in a globalized economic environment. The essence and components of the concept of marketing management are considered. The typology of forms of marketing management was conducted, which was agreed with a set of marketing mix strategies of an enterprise and the selection of lifecycle practices. Peculiar enterprise lifecycle practices were substantiated for several forms of marketing management. The differences between marketing management functions implementation were determined for different management forms. The specifics of implementation were identified and options were recommended for strategic action as to marketing management change

Multiple-Quantum-Well Nonlinear Coupler

NRC publication: Ye

18th International Conference on Ontologies, DataBases, and Applications of Semantics (ODBASE 2019)

Managing privacy and understanding handling of personal data has turned into a fundamental right, at least within the European Union, with the General Data Protection Regulation (GDPR) being enforced since May 25th 2018. This has led to tools and services that promise compliance to GDPR in terms of consent management and keeping track of personal data being processed. The information recorded within such tools, as well as that for compliance itself, needs to be interoperable to provide sufficient transparency in its usage. Additionally, interoperability is also necessary towards addressing the right to data portability under GDPR as well as creation of user-configurable and manageable privacy policies. We argue that such interoperability can be enabled through agreement over vocabularies using linked data principles. The W3C Data Privacy Vocabulary and Controls Community Group (DPVCG) was set up to jointly develop such vocabularies towards interoperability in the context of data privacy. This paper presents the resulting Data Privacy Vocabulary (DPV), along with a discussion on its potential uses, and an invitation for feedback and participation