6 research outputs found
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine
- Author
- AB Katende
- AK Nadkarni
- AM Dondorp
- AS Verkman
- B Graz
- B Graz
- B Graz
- B Patwardhan
- Bertrand Graz
- CA Simoes-Pires
- Chiaka Diakite
- D Diallo
- D Diallo
- D Frohne
- Drissa Diallo
- F Benoit-Vical
- G-Y Pan
- IP Guissou
- J Addae-Kyreme
- J Barnes
- JA DiMasi
- Jacques Falquet
- M Guindo
- M Willcox
- Merlin L Willcox
- ML Willcox
- ML Willcox
- ML Willcox
- ML Willcox
- O Sidibe
- S Blair
- S Mills
- S Nwaka
- S Nwaka
- SB Sirima
- Sergio Giani
- SH-l Lei
- SK Verma
- T Adjobimey
- WHO
- WHO
- WHO
- WHO
- WHO
- WHO
- WHO
- WHO
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
A “reverse pharmacology” approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of “reverse pharmacology” shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered
Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain
- Author
- A Sarkar
- A Villagra
- AJ Sales
- AS Brown
- Aye M. Myint
- B Ravi
- B Tang
- C Simoes-Pires
- CA Zarate
- CM Connor
- Daniel L. A. van den Hove
- DR Grayson
- FA Schroeder
- FA Schroeder
- FH Bardai
- Gunter Kenis
- H Nawa
- H Zhou
- Harry W. M. Steinbusch
- HE Covington 3rd
- HJ Sørensen
- HM Golan
- IA Qureshi
- J Borrell
- J Doukas
- J Lu
- JC Snell
- JH Gilmore
- K Ozawa
- Karin Neumeier
- L Zuckerman
- M Cantley
- M Enayati
- M Fukada
- MJ Morris
- MR Shakespear
- NM Tsankova
- P Lirk
- Peter Zill
- Q Li
- RH Chapman
- S Babri
- S Bahari-Javan
- SC McQuown
- SH Fatemi
- Sylvia de Jonge
- T Yamaguchi
- U Meyer
- U Meyer
- U Meyer
- Waldtraud Stettinger
- Y Yamawaki
- Yara Pujol Lopez
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds from Syzygium cumini
- Author
- Aher AN
- Amit Agarwal
- Anirban Bhaskar
- Arun R
- Ayyanar M
- Ayyanar M
- Baliga MS
- Banerjee J
- Bhuyan ZA
- Bona DKS
- Brito FA
- Burke TR
- Chaudhary B
- Deepak Mundkinajeddu
- Gohar AA
- Gowri SS
- Hayman S
- Helmstadter A
- Jadhav VM
- Jaya Balachandran
- Khan N
- Kumar A
- Laxman Sawant
- Lee HS
- Muruganandan S
- Oliveira AC
- Omar R
- Rekha N
- Rodrigues MT
- Sagrawat H
- Saravanan G
- Sharma B
- Sharma SB
- Shekhar Dethe
- Simoes-Pires CA
- Srivastava S
- Tanaka JCA
- Vineet Kumar Singh
- Weichselbaum TE
- Yamada P
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules
- Author
- A Bobrowska
- A Matsuyama
- A Szyk
- AA Hyman
- AD Tran
- B Edde
- BA Eipper
- BE Schultz
- BJ North
- C Choudhary
- C Hubbert
- C Seidel
- C Simoes-Pires
- CA Moores
- CW Chu
- D Riester
- DR Friedmann
- E Nogales
- E Purev
- FF Wagner
- G Geuens
- G Giannini
- G Li
- G Piperno
- GG Gundersen
- GI Aldana-Masangkay
- H Li
- H Ouyang
- H Zou
- J Asthana
- J Schindelin
- JA Bergman
- JJ Kovacs
- JP Dompierre
- JS Akella
- K Okuda
- KA Williams
- M Braun
- M Taschner
- M Watabe
- MJ Lai
- N Kalebic
- N Ly
- NA Reed
- P Meurer-Grob
- RB Parmigiani
- RH Skoge
- RH Skoge
- S Chen
- SC Howes
- SG Jeong
- SG Wolf
- SW L’Hernault
- V Lafarga
- V Redeker
- W Li
- X Zhang
- Y Du
- Y Hai
- Y Han
- Y Huan
- Y Kawaguchi
- Y Li
- Y Liu
- Y Miyake
- Y Song
- Y Zhang
- Y Zhang
- Z Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
- Author
- A Asase
- A Asefa
- A Assefa
- A Belayneh
- A Belayneh
- A Berhan
- A Debella
- A Eneyew
- A Eneyew
- A Getahun
- A Koch
- A Maroyi
- A Mesfin
- A Teklay
- AL Dold
- AM Eshete
- Amha Worku
- B Abera
- B Abera
- B Bekele
- B Cubukcu
- B Mengiste
- Befikadu Urga
- C Vonthron-Senecheau
- CA Simoes-Pires
- CN Muthaura
- D Abebe
- D Beche
- D Hunde
- D Hunde
- D Musuyu Muganza
- D Phillipson
- DH Feyssa
- DMN Gakunju
- E Andarge
- E Birhane
- E Lulekal
- E Lulekal
- EA Ashley
- EA Sofowora
- F Fullas
- F Mesfin
- F Mesfn
- F Ntie-Kang
- FMOH
- G Addis
- G Alemayehu
- G Alemayehu
- G Bekele
- G Bidla
- G Chekole
- G Yirga
- G Yirga
- G Zenebe
- Getachew Alebie
- GG Mengesha
- H Agisho
- H Ohigashi
- H Yineger
- HA Oketch-Rabah
- J Abbink
- JL Pousset
- JM Nguta
- JRS Tabuti
- K Balemie
- K Mesfin
- K Tolossa
- KAM Kuria
- L Bantie
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- LC Okpako
- LM Deck
- M Eyasu
- M Giday
- M Giday
- M Giday
- M Giday
- M Giday
- M Gidey
- M Katemo
- M Maryo
- M Megersa
- M Meragiaw
- M Ragunathan
- M Tadesse
- M Willcox
- MA Seid
- MF Adekunle
- MH Nkunya
- ML Willcox
- MS Mueller
- N Misganaw
- N Parvez
- NS Abdel-Azim
- O Kenea
- OA Idowu
- P Pillay
- PG Kirira
- PT Mpiana
- R Pankhurst
- R Regassa
- S Araya
- S Bah
- S Challand
- S Edwards
- S Getaneh
- S MacKinnon
- S Zerabruk
- SD Dibong
- SM Musa
- T Berhane
- T Birhanu
- T Flatie
- T Julianti
- T Ketema
- T Mekuanent
- T Seifu
- T Teklehaymanot
- T Teklehaymanot
- T Teklehaymanot
- T Temam
- T Wondimu
- UG Dori
- W Yao-De
- WHO
- WHO
- Y Limenih
- Z Birhanu
- Z Getnet
- Z Petros
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
B. Sprachwissenschaft.
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- Shkurti L. S. O. S.
- SiebenbĂĽrg
- SiebenbĂĽrg
- Sik
- Siliprandi O.
- Silvagni U.
- Singleton M.
- Sitzung
- Skalicka V.
- Skok P.
- Skok P.
- Skok P.
- Sofer J.
- Sofer J.
- Solano L. F.
- Sommerfeit A.
- Sonderdr
- Sorrento L.
- Sotayalfa
- Soyer J.
- Specht Fr
- Speiser E. A.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- Spitzer L.
- St. Mariu
- St. Pa
- Stampa G. A.
- Stanica C.
- Starr W. T.
- Stirling W. F.
- Stolz O.
- Storni J. S.
- Strafsburger Eide F.
- Straka
- Sturm S.
- Sturtevant E. H.
- Suchianu D. L
- Svennung J.
- Szadrowsky M.
- Tafeln
- Tagliavini C.
- Tagliavini C.
- TagliaYini C.
- Tamerle E.
- Tappolet E.
- Tappolet Ernst J.
- Tejera E.
- Terracini A.
- Th
- Theatre E.
- Thomas Antoine A.
- Ticaloiu I.D.
- Tiffin J.
- Tilander G.
- Tilander G.
- Tilander G.
- Tolmer L.
- Tolmer L.
- Tomba Silvia
- Tone G.
- Torres Rioseco D. M.
- Trager G. L.
- Trcimer K.
- Trendelenburg W.
- Tuttle E. H.
- Tuuiio O
- Tuulio
- Vandereuse J.
- Vandereuse J.
- Verbinä L
- Verhand
- Vgl F.
- Vidossi G.
- Vierling O
- Viotti M.
- Viscardi A.
- Voretzsch K.
- Väänänen V.
- Wade G. E.
- Wagner
- Wagner M. L.
- Wagner M. L.
- Wagner R.
- Wahlgren Ernst Gotthard A.
- Walgarth-Walinski J.
- Wallonie
- Warland J.
- Warland M.
- Wartburg W.
- WedlĂĽfef Eduard K.
- Werner J.
- Wigand Ruth
- Williams E. B.
- Windesheim
- Winkle
- Wiske F.
- Woodard C. M.
- Wright L. O.
- Wörterbuch S.
- Xherija K.
- Zanchi-Alberti C.
- Zehnder J.
- Zeitlin M. A.
- Zipf G. K.
- Zipfel A.
- Zur
- §andru
- §t O
- än
- änä
- ΚΕΡΑΜΟΠΟΥΛΟΣ
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1943
- Field of study