The Aguablanca Ni–(Cu) sulfide deposit, SW Spain: geologic and geochemical controls and the relationship with a midcrustal layered mafic complex

The Aguablanca Ni–(Cu) sulfide deposit is hosted by a breccia pipe within a gabbro–diorite pluton. The deposit probably formed due to the disruption of a partially crystallized layered mafic complex at about 12– 19 km depth and the subsequent emplacement of melts and breccias at shallow levels (<2 km). The ore-hosting breccias are interpreted as fragments of an ultramafic cumulate, which were transported to the near surface along with a molten sulfide melt. Phlogopite Ar–Ar ages are 341– 332 Ma in the breccia pipe, and 338–334 Ma in the layered mafic complex, and are similar to recently reported U–Pb ages of the host Aguablanca Stock and other nearby calcalkaline metaluminous intrusions (ca. 350–330 Ma). Ore deposition resulted from the combination of two critical factors, the emplacement of a layered mafic complex deep in the continental crust and the development of small dilational structures along transcrustal strike-slip faults that triggered the forceful intrusion of magmas to shallow levels. The emplacement of basaltic magmas in the lower middle crust was accompanied by major interaction with the host rocks, immiscibility of a sulfide melt, and the formation of a magma chamber with ultramafic cumulates and sulfide melt at the bottom and a vertically zoned mafic to intermediate magmas above. Dismembered bodies of mafic/ultramafic rocks thought to be parts of the complex crop out about 50 km southwest of the deposit in a tectonically uplifted block (Cortegana Igneous Complex, Aracena Massif). Reactivation of Variscan structures that merged at the depth of the mafic complex led to sequential extraction of melts, cumulates, and sulfide magma. Lithogeochemistry and Sr and Nd isotope data of the Aguablanca Stock reflect the mixing from two distinct reservoirs, i.e., an evolved siliciclastic middle-upper continental crust and a primitive tholeiitic melt. Crustal contamination in the deep magma chamber was so intense that orthopyroxene replaced olivine as the main mineral phase controlling the early fractional crystallization of the melt. Geochemical evidence includes enrichment in SiO2 and incompatible elements, and Sr and Nd isotope compositions (87Sr/86Sri 0.708–0.710; 143Nd/144Ndi 0.512–0.513). However, rocks of the Cortegana Igneous Complex have low initial 87Sr/86Sr and high initial 143Nd/144Nd values suggesting contamination by lower crustal rocks. Comparison of the geochemical and geological features of igneous rocks in the Aguablanca deposit and the Cortegana Igneous Complex indicates that, although probably part of the same magmatic system, they are rather different and the rocks of the Cortegana Igneous Complex were not the direct source of the Aguablanca deposit. Crust–magma interaction was a complex process, and the generation of orebodies was controlled by local but highly variable factors. The model for the formation of the Aguablanca deposit presented in this study implies that dense sulfide melts can effectively travel long distances through the continental crust and that dilational zones within compressional belts can effectively focus such melt transport into shallow environments

Peripheral Regulatory Cells Immunophenotyping in Kidney Transplant Recipients with Different Clinical Profiles: A Cross-Sectional Study

Regulatory Foxp3-expressing T cells (Tregs), IL-10-producing B cells (Bregs), and IDO-expressing dendritic cells (DCregs) downregulate inflammatory processes and induces peripheral tolerance. These subpopulations also might participate in maintaining allograft immunological quiescence in kidney transplant recipients (KTRs) with an excellent long-term graft function under immunosuppression (ELTGF). The aim of the study was to characterize and to enumerate peripheral Tregs, Bregs, and DCregs in KTR with an ELTGF for more than 5 years after transplant. Fourteen KTR with an ELTGF, 9 KTR with chronic graft dysfunction (CGD), and 12 healthy donors (HDs) were included in the study. CD19+-expressing peripheral B lymphocytes were purified by positive selection. IL-10-producing B cells, CD4+/CD25hi, and CD8+/CD28− Tregs, as well as CCR6+/CD123+/IDO+ DCs, were quantitated by flow cytometry. IL-10-producing Bregs (immature/transitional, but not CD19+/CD38hi/CD24hi/CD27+B10 cells), CCR6+/CD123+/IDO+ DCs, and Tregs from ELTGF patients had similar or higher percentages versus HD (P<0.05). By contrast, number of Tregs, DCregs, and Bregs except for CD27+B10 cells from CGD patients had lower levels versus HD and ELTGF patients (P<0.05). The findings of this exploratory study might suggest that in ELTGF patients, peripheral tolerance mechanisms could be directly involved in the maintenance of a quiescent immunologic state and graft function stability

Residual Effect of Lambdacyhalothrin on Triatorna infestans

Insecticidal residual effect and triatomine infestation rates in houses of a community fumigated with lambdcyhalothrin (Icon) are reported. No mortality was observed in 5th-instar Triatoma infestans nymphs in 72-hr exposure test on three different surfaces, one month after fumigation for a dose of 31.5 mg am/m^2. However, during post-exposure observation a mortality of 60% was recorded for those insect exposed on sprayed woodboard The results observed with mud-containing treated walls, were markedly poorer (0% of mortality). Twelve month after spraying 4096 of mortality was observed on first-instar T. infestans nymphs in 72-hr exposure test on woodborad but lower mortality rates were observed in mud-containing materials. When the effect of deltamethrin (109 mg ai/m^2) and lambdacyhalothrin (94 mg ai/m^2) was compared, the former did not appear to be superior at similar loads. Both have showed a mortality rate of 30% on 5th-instar T. infestans nymphs three montbs post-fumigation. The dose utilized in the field fumigation was enough to get a significant (p{ 0.0001) control of triatomine domestic infestation, since it was sufficient to keep 95 % of the houses uninfested throughout 21 months following treatment, when compared with baseline situation. A remarkable knock-down effect on adult and nymphs form of the insect and a high in situ mortality were observed as a result of its application, even at very low doses

Carcinoma bucal de células escamosas asociado a úlceras traumáticas crónicas

Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Lazos, Jerónimo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Panico, René Luis. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Simancas, C. Hospital Italiano. Laboratorio de Anatomía Patológica Genera; Argentina.Fil: Warnakulasuriya, Saman. King´s College London Dental Institute. Oral Medicine Department; England.ntecedentes: El carcinoma bucal de células escamosas (CBCE) está frecuentemente precedido por algún desorden oral potencialmente maligno (DOPM). Sin embargo, un porcentaje importante de CBCE podría originarse de mucosa clínicamente sana o de lesiones aún no catalogadas como DOPM. Se ha sugerido que la úlcera traumática crónica (UTC) es una lesión con potencial de transformación maligna, pero la evidencia no es concluyente. El objetivo de este estudio fue describir las características clínico-patológicas de UTC sin tendencia a la cicatrización (UTC-SC) que en su evolución mostraron cambios histopatológicos compatibles con un CBCE. Métodos: se realizó un estudio transversal de pacientes de la Facultad de Odontología Universidad Nacional de Córdoba (2013-2019). Se incluyeron pacientes con diagnóstico provisional de UTC. Después del control y remoción de factores traumatizantes, las UTC-SC fueron biopsiadas. Resultados: Se incluyeron 107 UTC. De estas, 32 UTC (30%) se consideraron como UTC-SC y solo 2 casos (1,86%) mostraron características histológicas de CBCE incipiente. En ambos casos de transformación maligna de UTC-SC, las lesiones estaban ubicadas en el borde de la lengua y en pacientes mujeres sin factores de riesgo clásicos de CBCE y sin DOPM. Conclusiones: Las UTC-SC podrían sufrir transformación maligna en una baja frecuencia, aunque similar a otros DOPM. No se debe subestimar la posibilidad de transformación maligna en un subconjunto de UTC-SC de borde de lengua. Se necesitan más estudios para validar nuestros hallazgos y considerar a la UTC-SC como un DPM.https://revistas.unc.edu.ar/index.php/RevFacOdonto/issue/view/2445/543Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Lazos, Jerónimo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Panico, René Luis. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Simancas, C. Hospital Italiano. Laboratorio de Anatomía Patológica Genera; Argentina.Fil: Warnakulasuriya, Saman. King´s College London Dental Institute. Oral Medicine Department; England.Odontología, Medicina y Cirugía Ora