<i>Aza</i>-Conjugate Addition Methodology for the Synthesis of <i>N</i>‑Hydroxy-isoindolin-1-ones

Aryl-aldehydes containing <i>ortho</i>-substituted propiolate fragments react with hydroxylamine to afford carbinolamine intermediates that undergo intramolecular <i>aza</i>-conjugate addition reactions to afford <i>N</i>-hydroxy-2.3-dihydro-isoindolin-1-ones that can be reduced to their corresponding isoindolin-1-ones and isoindoles