A Nominal Theory of the Nominal Rate of Interest and the Price Level: Some Empirical Evidence

This paper aims to investigate the impact of the bond/money ratio on the nominal interest rate. The econometric model chosen fits a dynamic panel data for Canada, Japan and US over the period 1980-2006. We found empirical evidence that Ricardian Equivalence does not hold. The analysis indicates, for the three countries, that the bond/money ratio affects the nominal interest rate.Government debt, Ricardian equivalence, bond/money ratio.

05 The South American Monsoon System: Climatology and Variability

A typical Monsoon System is characterized by a reversal in the low-level wind direction between summer and winter seasons, and distinct wet (summer) and dry (winter) periods. The changes in low-level atmospheric circulation are related to changes in the thermal contrast between oceans and continents. During summer, the air over continents is warmer and more convectively unstable than air over adjacent oceanic regions. Consequently, lower pressure occurs over land and higher pressure occurs over nearby oceanic areas. This pressure pattern causes low-level moist air to converge onto the land, resulting in precipitation, especially during the late afternoon and evening hours. During winter the temperature contrasts and low-level atmospheric circulation are reversed, resulting in dry conditions over continents.https://digitalcommons.usu.edu/modern_climatology/1004/thumbnail.jp

Bayesian Forecasting Of Temporal Gene Expression By Using An Autoregressive Panel Data Approach

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)We propose and evaluate a novel approach for forecasting gene expression over non-observed times in longitudinal trials under a Bayesian viewpoint. One of the aims is to cluster genes that share similar expression patterns over time and then use this similarity to predict relative expression at time points of interest. Expression values of 106 genes expressed during the cell cycle of Saccharomyces cerevisiae were used and genes were partitioned into five distinct clusters of sizes 33, 32, 21, 16, and 4. After removing the last observed time point, the agreements of signals (upregulated or downregulated) considering the predicted expression level were 72.7, 81.3, 76.2, 68.8, and 50.0%, respectively, for each cluster. The percentage of credibility intervals that contained the true values of gene expression for a future time was ~90%. The methodology performed well, providing a valid forecast of gene expression values by fitting an autoregressive panel data model. This approach is easily implemented with other time-series models and when Poisson and negative binomial probability distributions are assumed for the gene expression data. © FUNPEC-RP.152CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico#APQ 00825, FAPEMIG, Fundação de Amparo à Pesquisa do Estado de Minas GeraisFUNARBE, Fundação Arthur BernardesCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

De Branges spaces and Krein's theory of entire operators

This work presents a contemporary treatment of Krein's entire operators with deficiency indices $(1,1)$ and de Branges' Hilbert spaces of entire functions. Each of these theories played a central role in the research of both renown mathematicians. Remarkably, entire operators and de Branges spaces are intimately connected and the interplay between them has had an impact in both spectral theory and the theory of functions. This work exhibits the interrelation between Krein's and de Branges' theories by means of a functional model and discusses recent developments, giving illustrations of the main objects and applications to the spectral theory of difference and differential operators.Comment: 37 pages, no figures. The abstract was extended. Typographical errors were corrected. The bibliography style was change

Role of ¿1-pyrroline-5-carboxylate dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi

Proline is crucial for energizing critical events throughout the life cycle of Trypanosoma cruzi, the etiological agent of Chagas disease. The proline breakdown pathway consists of two oxidation steps, both of which produce reducing equivalents as follows: the conversion of proline to ¿1-pyrroline-5-carboxylate (P5C), and the subsequent conversion of P5C to glutamate. We have identified and characterized the ¿1-pyrroline-5-carboxy- late dehydrogenase from T. cruzi (TcP5CDH) and report here on how this enzyme contributes to a central metabolic pathway in this parasite. Size-exclusion chromatography, two-dimen- sional gel electrophoresis, and small angle x-ray scattering analysis of TcP5CDH revealed an oligomeric state composed of two subunits of six protomers. TcP5CDH was found to complement a yeast strain deficient in PUT2 activity, confirming the enzyme’s functional role; and the biochemical parameters (Km, kcat, and kcat/Km) of the recombinant TcP5CDH were determined, exhibiting values comparable with those from T. cruzi lysates. In addition, TcP5CDH exhibited mitochondrial staining during the main stages of the T. cruzi life cycle. mRNA and enzymatic activity levels indicated the up-regulation (6-fold change) of TcP5CDH during the infective stages of the parasite. The participation of P5C as an energy source was also demonstrated. Overall, we propose that this enzymatic step is crucial for the viability of both replicative and infective forms of T. cruzi

<i>Vibrio communis</i> sp. nov., isolated from the marine animals <i>Mussismilia hispida, Phyllogorgia dilatata, Palythoa caribaeorum, Palythoa variabilis</i> and <i>Litopenaeus vannamei</i>

Eight Vibrio isolates originating from the marine corals Mussismilia hispida and Phyllogorgia dilatata and the zoanthids Palythoa caribaeorum and Palythoa variabilis in Brazil and the Pacific white shrimp (Litopenaeus vannamei) in Ecuador were studied by means of a polyphasic approach. The novel isolates formed a tight monophyletic group in the genus Vibrio and were closely related to species of the Vibrio harveyi group, to which they showed more than 99?% 16S rRNA gene sequence similarity. Analysis based on concatenated sequences of the following seven genes, 16S rRNA, gyrB, recA, rpoA, topA, pyrH and mreB (5633 bp in length), showed clear separation between the isolates and species of the V. harveyi group. Amplified fragment length polymorphism (AFLP) analysis, performed previously, revealed that a representative isolate of this group, LMG 20370, was clearly separate from known Vibrio species (it belonged to the so-called AFLP cluster A31). DNA–DNA hybridization (DDH) experiments with representative isolates and type strains of the V. harveyi species group revealed high DDH between the novel isolates (more than 74?%) and less than 70?% DDH towards type strains of related Vibrio species, proving the novel species status of the isolates. Phenotypically, the novel species belongs to the arginine dihydrolase (A)-negative, lysine decarboxylase (L)-positive and ornithine decarboxylase (O)-positive (A-/L+/O+) cluster reported previously. Most species of the V. harveyi group (i.e. Vibrio rotiferianus, V. harveyi, V. parahaemolyticus and V. alginolyticus) also belong to this A-/L+/O+ cluster. However, several phenotypic features can be used for the identification of the novel species. In contrast to its closest phylogenetic neighbours, the novel species exhibits esterase (C4) and N-acetyl-ß-glucosaminidase activities, but it does not produce acetoin, does not use citrate, a-ketoglutaric acid or propionic acid and does not ferment melibiose. The novel species can also be differentiated on the basis of the presence of the fatty acids C17?:?0, C17?:?1?8c, iso-C17?:?0 and iso-C13?:?0 and the absence of the fatty acid C18?:?0. The name Vibrio communis sp. nov. is proposed for this taxon. Strain R-40496T (=LMG 25430T =CAIM 1816T) is the type strain

Huge metastability in high-T_c superconductors induced by parallel magnetic field

We present a study of the temperature-magnetic field phase diagram of homogeneous and inhomogeneous superconductivity in the case of a quasi-two-dimensional superconductor with an extended saddle point in the energy dispersion under a parallel magnetic field. At low temperature, a huge metastability region appears, limited above by a steep superheating critical field (H_sh) and below by a strongly reentrant supercooling field (H_sc). We show that the Pauli limit (H_p) for the upper critical magnetic field is strongly enhanced due to the presence of the Van Hove singularity in the density of states. The formation of a non-uniform superconducting state is predicted to be very unlikely.Comment: 5 pages, 2 figures; to appear in Phys. Rev.

Possible symmetries of the superconducting order parameter in a hexagonal ferromagnet

We study the order parameter symmetry in a hexagonal crystal with co-existing superconductivity and ferromagnetism. An experimental example is provided by carbon-based materials, such as graphite-sulfur composites, in which an evidence of such co-existence has been recently discovered. The presence of a non-zero magnetization in the normal phase brings about considerable changes in the symmetry classification of superconducting states, compared to the non-magnetic case.Comment: 4 pages, REVTe

Prioritizing Complex Issues of Hydrographic Basin Committees by Group Decision Approach

In Brazil, the hydrographic basin committees are the centre of decision for water resource management in their respective basins. The committee members, who represent the public sector, water users and civil society, must decide about complex issues, requesting the consideration of multiple aspects: economic, social and environmental. Given the complexity of the decision-making process, it is advantageous to have a decision support system that guarantees transparency, rapidness and, specially, a structured analysis of the problem, incorporating all aspects of the situation. This paper presents a group decision making model based on multicriteria analyses to support the members of a hydrographic basin committee to prioritize complex issues, in special activities to control the environmental degradation The proposed model works through two steps: firstly is used the PROMETHEE II method to achieve the individual rankings of alternatives, and secondly, the individual rankings of alternatives are aggregated to attain the global ranking, applying the ELECTRE IV method, reflecting the preference of the group

A prediction algorithm for drug response in patients with mesial temporal lobe epilepsy based on clinical and genetic information

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOMesial temporal lobe epilepsy is the most common form of adult epilepsy in surgical series. Currently, the only characteristic used to predict poor response to clinical treatment in this syndrome is the presence of hippocampal sclerosis. Single nucleotide121FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2013/07559-