1,586 research outputs found
Continuous input nonlocal games
We present a family of nonlocal games in which the inputs the players receive
are continuous. We study three representative members of the family. For the
first two a team sharing quantum correlations (entanglement) has an advantage
over any team restricted to classical correlations. We conjecture that this is
true for the third member of the family as well.Comment: Journal version, slight modification
Four Decades of Andean Timberline Migration and Implications for Biodiversity Loss with Climate Change
Rapid 21st-century climate change may lead to large population decreases and extinction in tropical montane cloud forest species in the Andes. While prior research has focused on species migrations per se, ecotones may respond to different environmental factors than species. Even if species can migrate in response to climate change, if ecotones do not they can function as hard barriers to species migrations, making ecotone migrations central to understanding species persistence under scenarios of climate change. We examined a 42-year span of aerial photographs and high resolution satellite imagery to calculate migration rates of timberline–the grassland-forest ecotone–inside and outside of protected areas in the high Peruvian Andes. We found that timberline in protected areas was more likely to migrate upward in elevation than in areas with frequent cattle grazing and fire. However, rates in both protected (0.24 m yr-1) and unprotected (0.05 m yr-1) areas are only 0.5–2.3% of the rates needed to stay in equilibrium with projected climate by 2100. These ecotone migration rates are 12.5 to 110 times slower than the observed species migration rates within the same forest, suggesting a barrier to migration for mid- and high-elevation species. We anticipate that the ecotone will be a hard barrier to migration under future climate change, leading to drastic population and biodiversity losses in the region unless intensive management steps are taken
The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome
The EPR experiment in the energy-based stochastic reduction framework
We consider the EPR experiment in the energy-based stochastic reduction
framework. A gedanken set up is constructed to model the interaction of the
particles with the measurement devices. The evolution of particles' density
matrix is analytically derived. We compute the dependence of the
disentanglement rate on the parameters of the model, and study the dependence
of the outcome probabilities on the noise trajectories. Finally, we argue that
these trajectories can be regarded as non-local hidden variables.Comment: 11 pages, 5 figure
The performance of anti–cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: Results from the Norfolk Arthritis Register
Evidence-Informed Guidelines for Pediatric Pandemic Planning and Response
From the executive summary:
Pandemic events are unpredictable and inevitable. When they occur, the impact is both all-encompassing and asymmetrical; each pandemic targets specific, vulnerable populations, but ultimately impacts individuals, families and communities throughout the world. Regardless of origin or circumstances, the next pandemic will certainly count infants, children, and adolescents among its most vulnerable targets. As evidenced by the 2009 H1N1 influenza pandemic, children may be at higher risk than populations more typically seen as susceptible to pandemic illness (the elderly, those with weakened immune systems, etc.). Children also can function as disease vectors, spreading the virus through their ubiquitous presence in settings where they live, attend school, and play.
This document is the result of a two-year international, mixed-methods study of the physical, social, and mental health effects of pandemic on children and families – particularly the impact of quarantine and hospital isolation during these events. This project also examined the psychosocial effects of pandemic disaster on professionals who care for children before, during, and after pandemic. Based on the empirical findings of this study, researchers developed a set of evidence-informed, child-focused, best practice guidelines for use by stakeholders during future pandemics across a variety of relevant fields. In addition, data gathered and analyzed for the project have been used to create a set of Kentucky-specific recommendations that respond to the state’s unique geographic and population needs
Non-steroidal anti-inflammatory drug use does not appear to be associated with increased cardiovascular mortality in patients with inflammatory polyarthritis: results from a primary care based inception cohort of patients
Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza interventions and vaccines. The 2009 pandemic influenza virus (H1N1pdm09) induces mild to moderate respiratory disease in infected ferrets, following inoculation with 106 plaque-forming units (pfu) of virus. We have demonstrated that reducing the challenge dose to 102 pfu delays the onset of clinical signs by 1 day, and results in a modest reduction in clinical signs, and a less rapid nasal cavity innate immune response. There was also a delay in virus production in the upper respiratory tract, this was up to 9-fold greater and virus shedding was prolonged. Progression of infection to the lower respiratory tract was not noticeably delayed by the reduction in virus challenge. A dose of 104 pfu gave an infection that was intermediate between those of the 106 pfu and 102 pfu doses. To address the hypothesis that using a more authentic low challenge dose would facilitate a more sensitive model for antiviral efficacy, we used the well-known neuraminidase inhibitor, oseltamivir. Oseltamivir-treated and untreated ferrets were challenged with high (106 pfu) and low (102 pfu) doses of influenza H1N1pdm09 virus. The low dose treated ferrets showed significant delays in innate immune response and virus shedding, delayed onset of pathological changes in the nasal cavity, and reduced pathological changes and viral RNA load in the lung, relative to untreated ferrets. Importantly, these observations were not seen in treated animals when the high dose challenge was used. In summary, low dose challenge gives a disease that more closely parallels the disease parameters of human influenza infection, and provides an improved pre-clinical model for the assessment of influenza therapeutics, and potentially, influenza vaccines
Serious Infection Following Anti–Tumor Necrosis Factor α Therapy in Patients With Rheumatoid Arthritis: Lessons From Interpreting Data From Observational Studies
Flipping quantum coins
Coin flipping is a cryptographic primitive in which two distrustful parties
wish to generate a random bit in order to choose between two alternatives. This
task is impossible to realize when it relies solely on the asynchronous
exchange of classical bits: one dishonest player has complete control over the
final outcome. It is only when coin flipping is supplemented with quantum
communication that this problem can be alleviated, although partial bias
remains. Unfortunately, practical systems are subject to loss of quantum data,
which restores complete or nearly complete bias in previous protocols. We
report herein on the first implementation of a quantum coin-flipping protocol
that is impervious to loss. Moreover, in the presence of unavoidable
experimental noise, we propose to use this protocol sequentially to implement
many coin flips, which guarantees that a cheater unwillingly reveals
asymptotically, through an increased error rate, how many outcomes have been
fixed. Hence, we demonstrate for the first time the possibility of flipping
coins in a realistic setting. Flipping quantum coins thereby joins quantum key
distribution as one of the few currently practical applications of quantum
communication. We anticipate our findings to be useful for various
cryptographic protocols and other applications, such as an online casino, in
which a possibly unlimited number of coin flips has to be performed and where
each player is free to decide at any time whether to continue playing or not.Comment: 17 pages, 3 figure
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