1,207 research outputs found
The StarView intelligent query mechanism
The StarView interface is being developed to facilitate the retrieval of scientific and engineering data produced by the Hubble Space Telescope. While predefined screens in the interface can be used to specify many common requests, ad hoc requests require a dynamic query formulation capability. Unfortunately, logical level knowledge is too sparse to support this capability. In particular, essential formulation knowledge is lost when the domain of interest is mapped to a set of database relation schemas. Thus, a system known as QUICK has been developed that uses conceptual design knowledge to facilitate query formulation. By heuristically determining strongly associated objects at the conceptual level, QUICK is able to formulate semantically reasonable queries in response to high-level requests that specify only attributes of interest. Moreover, by exploiting constraint knowledge in the conceptual design, QUICK assures that queries are formulated quickly and will execute efficiently
Quantum Correlations in Two-Particle Anderson Localization
We predict the quantum correlations between non-interacting particles
evolving simultaneously in a disordered medium. While the particle density
follows the single-particle dynamics and exhibits Anderson localization, the
two-particle correlation develops unique features that depend on the quantum
statistics of the particles and their initial separation. On short time scales,
the localization of one particle becomes dependent on whether the other
particle is localized or not. On long time scales, the localized particles show
oscillatory correlations within the localization length. These effects can be
observed in Anderson localization of non-classical light and ultra-cold atoms.Comment: 4 pages, 4 figures, comments welcom
Integrating a local database into the StarView distributed user interface
A distributed user interface to the Space Telescope Data Archive and Distribution Service (DADS) known as StarView is being developed. The DADS architecture consists of the data archive as well as a relational database catalog describing the archive. StarView is a client/server system in which the user interface is the front-end client to the DADS catalog and archive servers. Users query the DADS catalog from the StarView interface. Query commands are transmitted via a network and evaluated by the database. The results are returned via the network and are displayed on StarView forms. Based on the results, users decide which data sets to retrieve from the DADS archive. Archive requests are packaged by StarView and sent to DADS, which returns the requested data sets to the users. The advantages of distributed client/server user interfaces over traditional one-machine systems are well known. Since users run software on machines separate from the database, the overall client response time is much faster. Also, since the server is free to process only database requests, the database response time is much faster. Disadvantages inherent in this architecture are slow overall database access time due to the network delays, lack of a 'get previous row' command, and that refinements of a previously issued query must be submitted to the database server, even though the domain of values have already been returned by the previous query. This architecture also does not allow users to cross correlate DADS catalog data with other catalogs. Clearly, a distributed user interface would be more powerful if it overcame these disadvantages. A local database is being integrated into StarView to overcome these disadvantages. When a query is made through a StarView form, which is often composed of fields from multiple tables, it is translated to an SQL query and issued to the DADS catalog. At the same time, a local database table is created to contain the resulting rows of the query. The returned rows are displayed on the form as well as inserted into the local database table. Identical results are produced by reissuing the query to either the DADS catalog or to the local table. Relational databases do not provide a 'get previous row' function because of the inherent complexity of retrieving previous rows of multiple-table joins. However, since this function is easily implemented on a single table, StarView uses the local table to retrieve the previous row. Also, StarView issues subsequent query refinements to the local table instead of the DADS catalog, eliminating the network transmission overhead. Finally, other catalogs can be imported into the local database for cross correlation with local tables. Overall, it is believe that this is a more powerful architecture for distributed, database user interfaces
Mechanism of Ivermectin Facilitation of Human P2X4 Receptor Channels
Ivermectin (IVM), a widely used antiparasitic agent in human and veterinary medicine, was recently shown to augment macroscopic currents through rat P2X4 receptor channels (Khakh, B.S., W.R. Proctor, T.V. Dunwiddie, C. Labarca, and H.A. Lester. 1999. J. Neurosci. 19:7289–7299.). In the present study, the effects of IVM on the human P2X4 (hP2X4) receptor channel stably transfected in HEK293 cells were investigated by recording membrane currents using the patch clamp technique. In whole-cell recordings, IVM (≤10 μM) applied from outside the cell (but not from inside) increased the maximum current activated by ATP, and slowed the rate of current deactivation. These two phenomena likely result from the binding of IVM to separate sites. A higher affinity site (EC50 0.25 μM) increased the maximal current activated by saturating concentrations of ATP without significantly changing the rate of current deactivation or the EC50 and Hill slope of the ATP concentration-response relationship. A lower affinity site (EC50 2 μM) slowed the rate of current deactivation, and increased the apparent affinity for ATP. In cell-attached patch recordings, P2X4 receptor channels exhibited complex kinetics, with multiple components in both the open and shut distributions. IVM (0.3 μM) increased the number of openings per burst, without significantly changing the mean open or mean shut time within a burst. At higher concentrations (1.5 μM) of IVM, two additional open time components of long duration were observed that gave rise to long-lasting bursts of channel activity. Together, the results suggest that the binding of IVM to the higher affinity site increases current amplitude by reducing channel desensitization, whereas the binding of IVM to the lower affinity site slows the deactivation of the current predominantly by stabilizing the open conformation of the channel
Quantum Walk of Two Interacting Bosons
We study the effect of interactions on the bosonic two-particle quantum walk
and its corresponding spatial correlations. The combined effect of interactions
and Hanbury-Brown Twiss interference results in unique spatial correlations
which depend on the strength of the interaction, but not on its sign. The
results are explained in light of the two-particle spectrum and the physics of
attractively and repulsively bound pairs. We experimentally measure the weak
interaction limit of these effects in nonlinear photonic lattices. Finally, we
discuss an experimental approach to observe the strong interaction limit using
single atoms in optical lattices.Comment: 4 pages, 5 figures. Comments wellcom
Distinct Axonemal Processes Underlie Spontaneous and Stimulated Airway Ciliary Activity
Cilia are small organelles protruding from the cell surface that beat synchronously, producing biological transport. Despite intense research for over a century, the mechanisms underlying ciliary beating are still not well understood. Even the nature of the cytosolic molecules required for spontaneous and stimulated beating is debatable. In an effort to resolve fundamental questions related to cilia beating, we developed a method that integrates the whole-cell mode of the patch-clamp technique with ciliary beat frequency measurements on a single cell. This method enables to control the composition of the intracellular solution while the cilia remain intact, thus providing a unique tool to simultaneously investigate the biochemical and physiological mechanism of ciliary beating. Thus far, we investigated whether the spontaneous and stimulated states of cilia beating are controlled by the same intracellular molecular mechanisms. It was found that: (a) MgATP was sufficient to support spontaneous beating. (b) Ca2+ alone or Ca2+-calmodulin at concentrations as high as 1 μM could not alter ciliary beating. (c) In the absence of Ca2+, cyclic nucleotides produced a moderate rise in ciliary beating while in the presence of Ca2+ robust enhancement was observed. These results suggest that the axonemal machinery can function in at least two different modes
Parametric Self-Oscillation via Resonantly Enhanced Multiwave Mixing
We demonstrate an efficient nonlinear process in which Stokes and anti-Stokes
components are generated spontaneously in a Raman-like, near resonant media
driven by low power counter-propagating fields. Oscillation of this kind does
not require optical cavity and can be viewed as a spontaneous formation of
atomic coherence grating
All-Optical Switching with Transverse Optical Patterns
We demonstrate an all-optical switch that operates at ultra-low-light levels
and exhibits several features necessary for use in optical switching networks.
An input switching beam, wavelength , with an energy density of
photons per optical cross section [] changes
the orientation of a two-spot pattern generated via parametric instability in
warm rubidium vapor. The instability is induced with less than 1 mW of total
pump power and generates several Ws of output light. The switch is
cascadable: the device output is capable of driving multiple inputs, and
exhibits transistor-like signal-level restoration with both saturated and
intermediate response regimes. Additionally, the system requires an input power
proportional to the inverse of the response time, which suggests thermal
dissipation does not necessarily limit the practicality of optical logic
devices
Hanbury Brown and Twiss Correlations of Anderson Localized Waves
When light waves propagate through disordered photonic lattices, they can
eventually become localized due to multiple scattering effects. Here we show
experimentally that while the evolution and localization of the photon density
distribution is similar in the two cases of diagonal and off-diagonal disorder,
the density-density correlation carries a distinct signature of the type of
disorder. We show that these differences reflect a symmetry in the spectrum and
eigenmodes that exists in off-diagonally disordered lattices but is absent in
lattices with diagonal disorder.Comment: 4 pages, 3 figures, comments welcom
Fast high-efficiency integrated waveguide photodetectors using novel hybrid vertical/butt coupling geometry
We report a novel coupling geometry for integrated waveguide photodetectors−a hybrid vertical coupling/butt coupling scheme that allows the integration of fast, efficient, photodetectors with conventional double heterostructure waveguides. It can be employed to yield a planar, or pseudo-planar, surface that supports further levels of integration. The approach is demonstrated with a 25-µm-long p-i-n detector integrated with an InP/InGaAsP/InP waveguide, which displays a high (~90%) efficiency and large (~15 GHz) bandwidth. This is the fastest high-efficiency integrated waveguide photodetector reported to date
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