9 research outputs found
Life Quality Impairment Caused by Hookworm-Related Cutaneous Larva Migrans in Resource-Poor Communities in Manaus, Brazil
Hookworm-related cutaneous larva migrans (CLM) is a parasitic skin disease common in developing countries with hot climates. In resource-poor settings, CLM is associated with considerable morbidity. The disease is caused by animal hookworm larvae that penetrate the skin and migrate aimlessly in the epidermis as they cannot penetrate the basal membrane. Particularly in the rainy season, the intensity of infection is high with up to 40 larval tracks in an affected individual. Tracks are very itchy and are surrounded by a significant inflammation of the skin. Bacterial superinfection is common and intensifies the inflammation. The psychosocial consequences caused by CLM have never been investigated. We showed that CLM causes skin disease-associated life quality impairment in 91 patients with CLM. Skin disease-associated life quality was significantly impaired. The degree of impairment correlated to the intensity of infection and the number of body areas affected. After treatment with ivermectin, life quality was rapidly restored
Clinical and demographic characteristics of patients with CLM (n = 91).
a<p>multiple classifications possible.</p>b<p>pustules, suppuration, abscess.</p>c<p>in case of multiple lesions, appearance of the oldest.</p
Correlation between the number of affected areas and impairment of skin disease-associated life quality (rho = 0.36; p = 0.004).
<p>Correlation between the number of affected areas and impairment of skin disease-associated life quality (rho = 0.36; p = 0.004).</p
Dermatology life quality impairment in patients with CLM (n = 91).
<p>Dermatology life quality impairment in patients with CLM (n = 91).</p
Impairment of life quality in adult and child patients with CLM (n = 91).
a<p>only employed patients analyzed.</p>b<p>n = 87.</p>c<p>n = 7.</p
Categories of the modified Dermatology Life Quality Index.
<p>Categories of the modified Dermatology Life Quality Index.</p
Improvement of life quality after treatment with ivermectin.
a<p>≥2 points of the mDLQI.</p>b<p>only employed patients analyzed.</p
Correlation between severity of CLM and impairment of skin disease-associated life quality (rho = 0.76; p<0.001).
<p>Correlation between severity of CLM and impairment of skin disease-associated life quality (rho = 0.76; p<0.001).</p