Fibrillation in patients subjected to coronary artery bypass grafting

AbstractObjectiveAtrial fibrillation is the most frequently encountered postoperative arrhythmic complication after coronary artery bypass grafting. Ischemic preconditioning has proved a potent endogenous factor in suppressing ischemia-reperfusion–induced arrhythmias. The protective effect of ischemic preconditioning on atrial fibrillation after coronary artery bypass grafting has not been studied. The purpose of the present study was to investigate whether ischemic preconditioning had an effect on postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.MethodsEighty-five patients undergoing coronary artery bypass grafting were randomized into ischemic preconditioning and control groups. Holter data from 24-hour electrocardiography were collected 1 day before the operation to the second postoperative day. Atrial fibrillation was registered as positive if any atrial fibrillation event occurred.ResultsThe overall incidence of postoperative atrial fibrillation and sustained atrial fibrillation was 34.1% and 27.1%, respectively. The occurrence of atrial fibrillation was significantly lower in the ischemic preconditioning group (21.4% in patients undergoing ischemic preconditioning and 46.5% in control subjects, P = .015). Preoperative recent unstable angina did not influence the incidence of atrial fibrillation. Patients with atrial fibrillation had longer intensive care unit stays and compromised postoperative hemodynamic outcomes. Binary logistic regression analysis showed that ischemic preconditioning, preoperative mean heart rate, and postoperative pulmonary capillary wedge pressure were the independent predictors of atrial fibrillation.ConclusionsPostcoronary artery bypass grafting atrial fibrillation is associated with more complicated postoperative outcome. Higher preoperative heart rate and postoperative pulmonary capillary wedge pressure were the independent predictors of atrial fibrillation. Recent unstable angina is not related to the occurrence of postcoronary artery bypass grafting atrial fibrillation. Ischemic preconditioning significantly suppresses postcoronary artery bypass grafting atrial fibrillation, suggesting that ischemic preconditioning can be used as an effective prophylactic method for postoperative atrial fibrillation

Research trends of ferroptosis and pyroptosis in Parkinson’s disease: a bibliometric analysis

ObjectiveThis study aims to visualize the trends and hotspots in the research of “ferroptosis in PD” and “pyroptosis in PD” through bibliometric analysis from the past to 2024.MethodsLiterature was retrieved from the Web of Science Core Collection (WoSCC) from the past to February 16, 2024, and bibliometric analysis was conducted using Vosviewer and Citespace.Results283 and 542 papers were collected in the field of “ferroptosis in PD” and “pyroptosis in PD.” The number of publications in both fields has increased yearly, especially in “ferroptosis in PD,” which will become the focus of PD research. China, the United States and England had extensive exchanges and collaborations in both fields, and more than 60% of the top 10 institutions were from China. In the fields of “ferroptosis in PD” and “pyroptosis in PD,” the University of Melbourne and Nanjing Medical University stood out in terms of publication numbers, citation frequency, and centrality, and the most influential journals were Cell and Nature, respectively. The keyword time zone map showed that molecular mechanisms and neurons were the research hotspots of “ferroptosis in PD” in 2023, while memory and receptor 2 were the research hotspots of “pyroptosis in PD” in 2023, which may predict the future research direction.ConclusionThis study provides insights into the development, collaborations, research themes, hotspots, and tendencies of “ferroptosis in PD” and “pyroptosis in PD.” Overall situation of these fields is available for researchers to further explore the underlying mechanisms and potential treatments

Whether the CEO Turnover Can Improve the Conversion of Enterprise’s New and Old Driving Force?

After 2014, China focused on supply-side reform and put forward the concept of replacing old driving with new driving force, which can create a new round of economic improvement. From the perspective of the conversion of old and new driving forces of enterprises, this paper takes the listed enterprises in China’s a-share manufacturing industry from 2016 to 2018 as samples. This paper also discusses the “Net Effect” of CEO turnover on the conversion of new and old driving forces of enterprises. The results reflect that CEO turnover has a negative effect on the conversion of old and new driving force. Moving forward, when the CEO and chairman changes at the same time or the ownership of the enterprise turns to state-owned, the change of CEO has a higher degree of prevention on the conversion of old and new force. The number of board’s conferences and the degree of equity balance will increase the negative effect of CEO turnover on the conversion of old and new driving force

Wave Dissipation and Energy-Absorption Characteristics of Wave-Absorbing Metal Plates with Different Aperture Sizes and Thicknesses under True-Triaxial Static-Dynamic-Coupling Loading

Deep rock masses exist in a complex environment with multi-field coupling; therefore, it is necessary to develop a true-triaxial static-dynamic-coupling loading test machine to explore their characteristics and mechanical response mechanism. To meet the test requirements of true-triaxial loading and strong disturbance, a wave-absorbing metal plate was selected as the boundary material between the granite and transmission end, and the modified SHPB was used to perform static-dynamic-coupling loading tests. In this study, two series of experiments on wave- absorbing metal plates were conducted, which were fixed aperture sizes with different thicknesses and fixed thicknesses with different aperture sizes. The static-dynamic-coupling loading tests on each aperture size and plate thickness were carried out under the condition of equal energy impact. The effects of the aperture size and plate thickness on the incident- and reflection-stress curves, reflectivity, energy consumption law, energy evolution, and other mechanical properties of the wave-absorbing metal plate materials were studied. The results show that the peak stress and reflectivity decrease with increasing aperture size and plate thickness, and the influence of the thickness is greater than that of the aperture size. The energy-absorption rate of the wave-absorbing metal plate increased with increasing thickness and aperture size and was maximized when the aperture size and thickness were 6–7 mm and 3–4 mm, respectively. The variation trend of the energy reflectance is opposite to that of the energy absorption and reaches a minimum when the aperture size is 6–7 mm and plate thickness is 3–4 mm. The energy transmittance of the wave-absorbing metal plate fluctuated in a stable range, but the variation range was less obvious compared to that of the energy-absorption rate

Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease

AbstractDefibrotide (DF) is a mixture of porcine-derived single-stranded phosphodiester oligonucleotides (9-80-mer; average, 50-mer) that has been successfully used to treat severe hepatic veno-occlusive disease (sVOD) with multiorgan failure (MOF) in patients who have received cytotoxic chemotherapy in preparation for bone marrow transplantation. However, its mechanism of action is unknown. Herein, we show that DF and phosphodiester oligonucleotides can bind to heparin-binding proteins (eg, basic fibroblast growth factor [bFGF] but not vascular endothelial growth factor [VEGF] 165) with low nanomolar affinity. This binding occurred in a length- and concentration-dependent manner. DF can mobilize proangiogenic factors such as bFGF from their depot or storage sites on bovine corneal endothelial matrix. However, these molecules do not interfere with high-affinity binding of bFGF to FGFR1 IIIc but can replace heparin as a required cofactor for binding and hence cellular mitogenesis. DF also protects bFGF against digestion by trypsin and chymotrypsin and from air oxidation. In addition, DF binds to collagen I with low nanomolar affinity and can promote human microvascular endothelial cell-1 (HMEC-1) cell mitogenesis and tubular morphogenesis in three-dimensional collagen I gels. Thus, our data suggest that DF may provide a stimulus to the sinusoidal endothelium of a liver that has suffered a severe angiotoxic event, thus helping to ameliorate the clinical sVOD/MOF syndrome

Tidal Sediment Supply Maintains Marsh Accretion on the Yangtze Delta despite Rising Sea Levels and Falling Fluvial Sediment Input

Tidal marshes are among the world’s most valuable ecosystems; however, they are increasingly threatened by rising sea levels and a decline in fluvial sediment supply. The survival of a tidal marsh under these twin threats depends upon the net input of tidal sediments, because this will determine the deposition rate. The rate of relative sea level rise currently affecting the Yangtze Delta is rapid (~4 mm/a), and the sediment discharge from the Yangtze River has decreased by >70% over recent decades. In order to improve our understanding of the response of the marshes in the turbid zone of the Yangtze Estuary to these changing environmental conditions, we measured sediment transport in and out of a tidal basin and calculated the deposition rate over eight tidal cycles covering different tidal ranges during the summer and winter seasons. The suspended sediment concentration (SSC) during the flood phase of the tidal cycle (average = 0.395 kg/m3) was markedly higher than that during the ebb (average = 0.164 kg/m3), although water transport during the flood tide was almost equivalent to that during the ebb. As a result, ~40% of the sediment inflow during the flood phase was retained within the marsh. This reason is mainly attributable to the dense marsh vegetation, which attenuates waves and currents and to which the sediments adhere. The annual deposition rate in the marsh was approximately 6.7 mm/a. These findings indicate that under the combined influence of sea level rise and river sediment supply reduction, the sediment transport through the turbidity maximum zone of the Yangtze River estuary could maintain the relative stability of the marsh area to a certain extent

Tidal Sediment Supply Maintains Marsh Accretion on the Yangtze Delta despite Rising Sea Levels and Falling Fluvial Sediment Input

Tidal marshes are among the world’s most valuable ecosystems; however, they are increasingly threatened by rising sea levels and a decline in fluvial sediment supply. The survival of a tidal marsh under these twin threats depends upon the net input of tidal sediments, because this will determine the deposition rate. The rate of relative sea level rise currently affecting the Yangtze Delta is rapid (~4 mm/a), and the sediment discharge from the Yangtze River has decreased by >70% over recent decades. In order to improve our understanding of the response of the marshes in the turbid zone of the Yangtze Estuary to these changing environmental conditions, we measured sediment transport in and out of a tidal basin and calculated the deposition rate over eight tidal cycles covering different tidal ranges during the summer and winter seasons. The suspended sediment concentration (SSC) during the flood phase of the tidal cycle (average = 0.395 kg/m3) was markedly higher than that during the ebb (average = 0.164 kg/m3), although water transport during the flood tide was almost equivalent to that during the ebb. As a result, ~40% of the sediment inflow during the flood phase was retained within the marsh. This reason is mainly attributable to the dense marsh vegetation, which attenuates waves and currents and to which the sediments adhere. The annual deposition rate in the marsh was approximately 6.7 mm/a. These findings indicate that under the combined influence of sea level rise and river sediment supply reduction, the sediment transport through the turbidity maximum zone of the Yangtze River estuary could maintain the relative stability of the marsh area to a certain extent