Dust-wind interactions can intensify aerosol pollution over eastern China.

Eastern China has experienced severe and persistent winter haze episodes in recent years due to intensification of aerosol pollution. In addition to anthropogenic emissions, the winter aerosol pollution over eastern China is associated with unusual meteorological conditions, including weaker wind speeds. Here we show, based on model simulations, that during years with decreased wind speed, large decreases in dust emissions (29%) moderate the wintertime land-sea surface air temperature difference and further decrease winds by -0.06 (±0.05) m s-1 averaged over eastern China. The dust-induced lower winds enhance stagnation of air and account for about 13% of increasing aerosol concentrations over eastern China. Although recent increases in anthropogenic emissions are the main factor causing haze over eastern China, we conclude that natural emissions also exert a significant influence on the increases in wintertime aerosol concentrations, with important implications that need to be taken into account by air quality studies

Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology

Aim. To analyse the target of Rhizoma Curcumae in nasopharyngeal carcinoma by using network pharmacological techniques and to explore the associated molecular mechanism. Methods. The targets of nasopharyngeal carcinoma were retrieved from the GeneCards database. At the same time, the drug therapeutic targets of Rhizoma Curcumae were obtained from the TCMSP and SymMap databases. The data were imported into the STRING database and Cytoscape 3.7.1 to construct a network of “Chinese medicine component-target-disease” interactions; then, the intersection was screened as the core Rhizoma Curcumae antinasopharyngeal cancer targets. Through GO target function and KEGG pathway enrichment analyses of the core targets, we predicted the biological processes and key signalling pathways involved in the Rhizoma Curcumae treatment of nasopharyngeal carcinoma. Results. Twenty-five core targets of Rhizoma Curcumae in nasopharyngeal carcinoma were mined: TP53, BCL2 ICAM1 RXRA, TLR3 and TLR9, TNF, PTGS2, IL-6, CTSD, MMP2, MMP9, MMP14, TIMP2, ABCC1, ABCB1, ABCG2, and so on. The results of visual analysis showed that the Rhizoma Curcumae treatment of nasopharyngeal carcinoma mainly involves leukocyte adhesion to vascular endothelial cells, positive regulation of NF-κB import into the nucleus, regulation of the reactive oxygen species biosynthetic and metabolic process, regulation of the chemokine biosynthetic and metabolic process, various cancer-related signalling pathways, and a variety of cytokine signal transduction pathways, such as the NF-κB, TLR, IL-17, and TNF signalling pathways. Conclusion. The core targets predicted by our research can be used as molecular markers for the treatment and prediction of nasopharyngeal carcinoma. The mechanism of Rhizoma Curcumae treatment in NPC may be related to immune regulatory pathways, the inhibition of cancer cell proliferation, metastasis, and angiogenesis, as well as the regulation of tumour microenvironment. Combined with the prediction of its associated mechanism of action, the core targets can provide targeted reference value for subsequent drug development related to Curcuma

A Large-Scale Mouse Pose Dataset for Mouse Pose Estimation

Mouse pose estimations have important applications in the fields of animal behavior research, biomedicine, and animal conservation studies. Accurate and efficient mouse pose estimations using computer vision are necessary. Although methods for mouse pose estimations have developed, bottlenecks still exist. One of the most prominent problems is the lack of uniform and standardized training datasets. Here, we resolve this difficulty by introducing the mouse pose dataset. Our mouse pose dataset contains 40,000 frames of RGB images and large-scale 2D ground-truth motion images. All the images were captured from interacting lab mice through a stable single viewpoint, including 5 distinct species and 20 mice in total. Moreover, to improve the annotation efficiency, five keypoints of mice are creatively proposed, in which one keypoint is at the center and the other two pairs of keypoints are symmetric. Then, we created simple, yet effective software that works for annotating images. It is another important link to establish a benchmark model for 2D mouse pose estimations. We employed modified object detections and pose estimation algorithms to achieve precise, effective, and robust performances. As the first large and standardized mouse pose dataset, our proposed mouse pose dataset will help advance research on animal pose estimations and assist in application areas related to animal experiments

(Quantum) Time-Memory-Data Tradeoff Attacks on the SNOW-V Stream Cipher

Symmetric cryptosystems (i.e., stream ciphers and block ciphers) have always played an important part in securing the various generations of 3GPP (3rd Generation Partnership Project) mobile telephony systems. The SNOW-V stream cipher, published in September 2019, is the most recent member of the well-known SNOW family of ciphers. It is designed to provide confidentiality and integrity for 5G communications. There have been no time-memory-data tradeoff (TMDTO) attacks on the cipher published so far. By combining with the BSW sampling technique, we propose TMDTO attacks on SNOW-V. The results show that the attacker can mount a TMDTO attack, where none of the online time complexity, the memory complexity and the offline time complexity are bigger than 2256, if the keystream sequences generated by the secret key, together with different IVs, are provided to the attacker. Furthermore, we analyze the security of SNOW-V against quantum TMDTO attacks, and the results show that a quantum TMDTO attack offers, strictly, better online time complexity than Grover’s algorithm, when the available memory space is bigger than 2170.67. These results are helpful in evaluating the security of SNOW-V against (quantum) TMDTO attacks