Bibliometric analysis of the current status and trends on medical hyperspectral imaging

Hyperspectral imaging (HSI) is a promising technology that can provide valuable support for the advancement of the medical field. Bibliometrics can analyze a vast number of publications on both macroscopic and microscopic levels, providing scholars with essential foundations to shape future directions. The purpose of this study is to comprehensively review the existing literature on medical hyperspectral imaging (MHSI). Based on the Web of Science (WOS) database, this study systematically combs through literature using bibliometric methods and visualization software such as VOSviewer and CiteSpace to draw scientific conclusions. The analysis yielded 2,274 articles from 73 countries/regions, involving 7,401 authors, 2,037 institutions, 1,038 journals/conferences, and a total of 7,522 keywords. The field of MHSI is currently in a positive stage of development and has conducted extensive research worldwide. This research encompasses not only HSI technology but also its application to diverse medical research subjects, such as skin, cancer, tumors, etc., covering a wide range of hardware constructions and software algorithms. In addition to advancements in hardware, the future should focus on the development of algorithm standards for specific medical research targets and cultivate medical professionals of managing vast amounts of technical information

High Efficient Multisites Genome Editing in Allotetraploid Cotton (Gossypium Hirsutum) Using CRISPR/Cas9 System

Gossypium hirsutum is an allotetraploid with a complex genome. Most genes have multiple copies that belong to At and Dt subgenomes. Sequence similarity is also very high between gene homologues. To efficiently achieve site/gene‐specific mutation is quite needed. Due to its high efficiency and robustness, the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 system has exerted broad site‐specific genome editing from prokaryotes to eukaryotes. In this study, we utilized a CRISPR/Cas9 system to generate two sgRNAs in a single vector to conduct multiple sites genome editing in allotetraploid cotton. An exogenously transformed gene Discosoma red fluorescent protein2(DsRed2) and an endogenous gene GhCLA1 were chosen as targets. The DsRed2‐edited plants in T0 generation reverted its traits to wild type, with vanished red fluorescence the whole plants. Besides, the mutated phenotype and genotype were inherited to their T1 progenies. For the endogenous gene GhCLA1, 75% of regenerated plants exhibited albino phenotype with obvious nucleotides and DNA fragments deletion. The efficiency of gene editing at each target site is 66.7–100%. The mutation genotype was checked for both genes with Sanger sequencing. Barcode‐based high‐throughput sequencing, which could be highly efficient for genotyping to a population of mutants, was conducted in GhCLA1‐edited T0 plants and it matched well with Sanger sequencing results. No off‐target editing was detected at the potential off‐target sites. These results prove that the CRISPR/Cas9 system is highly efficient and reliable for allotetraploid cotton genome editing

Recent Advances in Polydopamine for Surface Modification and Enhancement of Energetic Materials: A Mini-Review

Polydopamine (PDA), inspired by the adhesive mussel foot proteins, is widely applied in chemical, biological, medical, and material science due to its unique surface coating capability and abundant active sites. Energetic materials (EMs) play an essential role in both military and civilian fields as a chemical energy source. Recently, PDA was introduced into EMs for the modification of crystal phase stability and the interfacial bonding effect, and, as a result, to enhance the mechanical, thermal, and safety performances. This mini-review summarizes the representative works in PDA modified EMs from three perspectives. Before that, the self-polymerization mechanisms of dopamine and the methods accelerating this process are briefly presented for consideration of researchers in this field. The future directions and remaining issues of PDA in this field are also discussed at last in this mini-review

Three-Dimensional Urban Expansion Analysis of Valley-Type Cities: A Case Study of Chengguan District, Lanzhou, China

The development of cities in the vertical dimension is important in valley-type cities where physical growth is limited by terrain. However, little research has focused on three-dimensional urban expansion of valley-type cities. Lanzhou is a typical valley-type city in China and Chengguan District is the core area of Lanzhou City. This research is aimed at understanding the development of valley-type cities through the analysis of the three-dimensional urban expansion of Lanzhou Chengguan District and providing a reference for urban planning. We extracted five periods of architectural contours and height information between 1975 to 2018 with the support of multi-source remote sensing and network data. We used overlay analysis and mathematical statistical methods to analyze urban horizontal expansion and used the building density, floor area ratio, vertical expansion speed, fluctuation degree, and skyline to analyze urban vertical expansion. We found that the mode of horizontal expansion of Chengguan District shifted from adjacency to enclave through mountain area reclamation. The area with the fastest vertical expansion speed first appeared in the horizontal expansion completed area, and then in both the rapid horizontal expansion area and in the horizontal expansion completed area. Before 2007, the speed of horizontal expansion increased and reached its peak while the vertical expansion speed was relatively stable. After that, the former decreased, and the vertical expansion increased rapidly and dominated the urban development. The vertical expansion of the valley-type city gradually dominates urban development. Urban planning should consider the three-dimensional expansion, especially in the vertical dimension

The impact of family violence incidents on personality changes: An examination of social media users' messages in China

Changes in personality tend to be intertwined with life events (e.g., family violence [FV]). This study aimed to examine the personality changes before and after an FV incident using Weibo data. Samples were selected from 1.16 million Weibo users in China who had posted their own FV experience as victims. We used Linguistic Inquiry and Word Count (LIWC) to extract the linguistic features of these unstructured texts as the scores of participants' personality. We built prediction models to measure and compare personality differences between the victim group and control group in Sample 1; and personality changes between the victim group and control group before and after an FV incident in Sample 2. Results showed that the victims' neuroticism increased and conscientiousness decreased after experiencing FV. At the same time, their agreeableness and openness levels were lower than those of the control group. Implications and limitations are also discussed

BMSC-Derived Exosomal CircHIPK3 Promotes Osteogenic Differentiation of MC3T3-E1 Cells via Mitophagy

Exosome-based therapy is emerging as a promising strategy to promote bone regeneration due to exosomal bioactive cargos, among which circular RNA (circRNA) has recently been recognized as the key effector. The role of exosomal circRNA derived from bone marrow mesenchymal stem cells (BMSCs) has not been well-defined. The present study aimed to clarify the regulatory function and molecular mechanism of BMSC-derived exosomal circRNA in osteogenesis. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) were isolated and identified. BMSC-Exos’ pro-osteogenic effect on MC3T3-E1 cells was validated by alkaline phosphatase (ALP) activity and Alizarin Red staining. Through bioinformatic analysis and molecular experiments, circHIPK3 was selected and verified as the key circRNA of BMSC-Exos to promote osteoblast differentiation of MC3T3-E1 cells. Mechanistically, circHIPK3 acted as an miR-29a-5p sponge and functioned in mitophagy via targeting miR-29a-5p and PINK1. Additionally, we showed that the mitophagy level of MC3T3-E1 cells were mediated by BMSC-Exos, which promoted the osteogenic differentiation. Collectively, our results revealed an important role for BMSC-derived exosomal circHIPK3 in osteogenesis. These findings provide a potentially effective therapeutic strategy for bone regeneration

Hot Oscillatory Pressing of Carbon Nanotube-Reinforced Copper Matrix Nanocomposite

Carbon nanotube reinforced copper matrix nanocomposites have great potential in machinery, microelectronics, and other applications. The materials are usually prepared by powder metallurgy processes, in which consolidation is a key step for high performance. To improve the density and mechanical properties, the authors explored the use of hot oscillatory pressing (HOP) to prepare this material. A carbon nanotube reinforced copper matrix nanocomposite was synthesized by both HOP and hot pressing (HP) at various temperatures, respectively. The samples prepared by HOP exhibited significantly higher density and hardness than those prepared by HP at the same temperature, and this was because the oscillatory pressure of HOP produced remarkable plastic deformation in copper matrix during sintering. With the decrease of sintering temperature in HOP, the amount of deformation defect increased gradually, playing a key role in the increasing hardness. This work proves experimentally for the first time that HOP can produce much more plastic deformation than HP to promote densification, and that HOP could be a very promising technique for preparing high-performance carbon nanotube reinforced copper matrix nanocomposites

Persistence of Immunity in Adults after 1, 5 and 10 Years with Recombinant Hepatitis B Vaccine in Beijing in 2010–2020

The persistence of immunity after hepatitis B vaccination is still under investigation in adults. In Chaoyang District, Beijing, people who were aged ≥ 18 years and completely immunized with HBV vaccine according to the standard procedure (0–1–6 months) were enrolled. Three groups were set for 1 (Y1), 5 (Y5) and 10 (Y10) years after the hepatitis B vaccination. The following data was collected and analyzed: antibody against hepatitis B virus surface antigen(anti-HBs) positive rates and geometric mean concentration (GMC) between the different compared groups through questionnaires and laboratory detection, including hepatitis B virus surface antigen (HBsAg), anti-HBs and antibody against hepatitis B virus core antigen(anti-HBc). All 600 subjects completed the questionnaires and serological tests. Among all subjects, the positive rates of HBsAg, anti-HBs and anti-HBc were 0, 70.5% (423/600) and 2.5% (15/600), respectively. The anti-HBs positive rates in Y1, Y5 and Y10 groups were 86.5% (173/200), 71.0% (142/200) and 54.0% (108/200) (χ2 = 50.8, p < 0.001) and showed a linear decreasing trend year by year (trend χ2 = 50.7, p < 0.001). The GMC in Y1, Y5 and Y10 groups were 296.6 mIU/mL, 51.6 mIU/mL and 25.5 mIU/mL (H = 64.8, p < 0.001), respectively. The anti-HBs positive rates and GMC decreased rapidly after the vaccination of adults against hepatitis B. Screening after 5–10 years and booster vaccination for the unprotected population is recommended