676 research outputs found
Cosmic 21-cm Delensing of Microwave Background Polarization and the Minimum Detectable Energy Scale of Inflation
The curl (B) modes of cosmic microwave background (CMB) polarization
anisotropies are a unique probe of the primordial background of inflationary
gravitational waves (IGWs). Unfortunately, the B-mode polarization anisotropies
generated by gravitational waves at recombination are confused with those
generated by the mixing of gradient-mode (E-mode) and B-mode polarization
anisotropies as CMB photons propagate through the Universe and are
gravitationally lensed. We describe here a method for delensing CMB
polarization anisotropies using observations of anisotropies in the cosmic
21-cm radiation emitted or absorbed by neutral hydrogen atoms at redshifts 10
to 200. While the detection of cosmic 21-cm anisotropies at high resolution is
challenging, a combined study with a relatively low-resolution (but
high-sensitivity) CMB polarization experiment could probe inflationary energy
scales well below the Grand Unified Theory (GUT) scale of 10^{16} GeV --
constraining models with energy scales below 10^{15} GeV (the detectable limit
derived from CMB observations alone). The ultimate theoretical limit to the
detectable inflationary energy scale via this method may be as low as 3 \times
10^{14} GeV.Comment: 4 pages, 2 figures, submitted to Phys. Rev. Let
Cosmological Signatures of Interacting Neutrinos
We investigate signatures of neutrino scattering in the Cosmic Microwave
Background (CMB) and matter power spectra, and the extent to which present
cosmological data can distinguish between a free streaming or tightly coupled
fluid of neutrinos. If neutrinos have strong non-standard interactions, for
example, through the coupling of neutrinos to a light boson, they may be kept
in equilibrium until late times. We show how the power spectra for these models
differ from more conventional neutrino scenarios, and use CMB and large scale
structure data to constrain these models. CMB polarization data improves the
constraints on the number of massless neutrinos, while the Lyman--
power spectrum improves the limits on the neutrino mass. Neutrino mass limits
depend strongly on whether some or all of the neutrino species interact and
annihilate. The present data can accommodate a number of tightly-coupled
relativistic degrees of freedom, and none of the interacting-neutrino scenarios
considered are ruled out by current data -- although considerations regarding
the age of the Universe disfavor a model with three annihilating neutrinos with
very large neutrino masses.Comment: 17 pages, 14 figures, minor changes and references added, published
in Phys. Rev.
Measuring the Primordial Deuterium Abundance During the Cosmic Dark Ages
We discuss how measurements of fluctuations in the absorption of cosmic
microwave background (CMB) photons by neutral gas during the cosmic dark ages,
at redshifts z ~ 7--200, could reveal the primordial deuterium abundance of the
Universe. The strength of the cross-correlation of brightness-temperature
fluctuations due to resonant absorption of CMB photons in the 21-cm line of
neutral hydrogen with those due to resonant absorption of CMB photons in the
92-cm line of neutral deuterium is proportional to the fossil deuterium to
hydrogen ratio [D/H] fixed during big bang nucleosynthesis (BBN). Although
technically challenging, this measurement could provide the cleanest possible
determination of [D/H], free from contamination by structure formation
processes at lower redshifts, and has the potential to improve BBN constraints
to the baryon density of the Universe \Omega_{b} h^2. We also present our
results for the thermal spin-change cross-section for deuterium-hydrogen
scattering, which may be useful in a more general context than we describe
here.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let
Preoperative FDG-PET/CT Is an Important Tool in the Management of Patients with Thick (T4) Melanoma
The yield of preoperative PET/CT (PET/CT) for regional and distant metastases for thin/intermediate thickness melanoma is low. Objective of this study is to determine if PET/CT performed for T4 melanomas helps guide management and alter treatment plans. Methods. Retrospective cohort of 216 patients with T4 melanomas treated at two tertiary institutions. Fifty-six patients met our inclusion criteria (T4 lesion, PET/CT and no clinical evidence of metastatic disease). Results. Fifty-six patients (M: 32, F: 24) with median tumor thickness of 6 mm were identified. PET/CT recognized twelve with regional and four patients with metastatic disease. Melanoma-related treatment plan was altered in 11% of the cases based on PET/CT findings. PET/CT was negative 60% of the time, in 35% of the cases; it identified incidental findings that required further evaluation. Conclusion. Patients with T4 lesions, PET/CT changed the treatment plan 18% of the time. Regional findings changed the surgical treatment plan in 11% and the adjuvant plan in 7% of our cases due to the finding of metastatic disease. Additionally 20 patients had incidental findings that required further workup. In this subset of patients, we feel there is a benefit to PET/CT, and further studies should be performed to validate our findings
Cosmic 21-cm Fluctuations as a Probe of Fundamental Physics
Fluctuations in high-redshift cosmic 21-cm radiation provide a new window for
observing unconventional effects of high-energy physics in the primordial
spectrum of density perturbations. In scenarios for which the initial state
prior to inflation is modified at short distances, or for which deviations from
scale invariance arise during the course of inflation, the cosmic 21-cm power
spectrum can in principle provide more precise measurements of exotic effects
on fundamentally different scales than corresponding observations of cosmic
microwave background anisotropies.Comment: 8 pages, 2 figure
Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus)
Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, remains prevalent in North American elk, white-tailed deer and mule deer. A natural case of CWD in reindeer (Rangifer tarandus tarandus) has not been reported despite potential habitat overlap with CWD-infected deer or elk herds. This study investigates the experimental transmission of CWD from elk or white-tailed deer to reindeer by the oral route of inoculation. Ante-mortem testing of the three reindeer exposed to CWD from white-tailed deer identified the accumulation of pathological PrP (PrPCWD) in the recto-anal mucosa associated lymphoid tissue (RAMALT) of two reindeer at 13.4 months post-inoculation. Terminal CWD occurred in the two RAMALT-positive reindeer at 18.5 and 20 months post-inoculation while one other reindeer in the white-tailed deer CWD inoculum group and none of the 3 reindeer exposed to elk CWD developed disease. Tissue distribution analysis of PrPCWD in CWD-affected reindeer revealed widespread deposition in central and peripheral nervous systems, lymphoreticular tissues, the gastrointestinal tract, neuroendocrine tissues and cardiac muscle. Analysis of prion protein gene (PRNP) sequences in the 6 reindeer identified polymorphisms at residues 2 (V/M), 129 (G/S), 138 (S/N) and 169 (V/M). These findings demonstrate that (i) a sub-population of reindeer are susceptible to CWD by oral inoculation implicating the potential for transmission to other Rangifer species, and (ii) certain reindeer PRNP polymorphisms may be protective against CWD infection
The Quintessential CMB, Past & Future
The past, present and future of cosmic microwave background (CMB) anisotropy
research is discussed, with emphasis on the Boomerang and Maxima balloon
experiments. These data are combined with large scale structure (LSS)
information and high redshift supernova (SN1) observations to explore the
inflation-based cosmic structure formation paradigm. Here we primarily focus on
a simplified inflation parameter set, {omega_b,omega_{cdm},Omega_{tot},
Omega_Q,w_Q, n_s,tau_C, sigma_8}. After marginalizing over the other cosmic and
experimental variables, we find the current CMB+LSS+SN1 data gives
Omega_{tot}=1.04\pm 0.05, consistent with (non-baroque) inflation theory.
Restricting to Omega_{tot}=1, we find a nearly scale invariant spectrum, n_s
=1.03 \pm 0.07. The CDM density, omega_{cdm}=0.17\pm 0.02, is in the expected
range, but the baryon density, omega_b=0.030\pm 0.004, is slightly larger than
the current nucleosynthesis estimate. Substantial dark energy is inferred,
Omega_Q\approx 0.68\pm 0.05, and CMB+LSS Omega_Q values are compatible with the
independent SN1 estimates. The dark energy equation of state, parameterized by
a quintessence-field pressure-to-density ratio w_Q, is not well determined by
CMB+LSS (w_Q<-0.3 at 95%CL), but when combined with SN1 the resulting w_Q<-0.7
limit is quite consistent with the w_Q=-1 cosmological constant case. Though
forecasts of statistical errors on parameters for current and future
experiments are rosy, rooting out systematic errors will define the true
progress.Comment: 14 pages, 3 figs., in Proc. CAPP-2000 (AIP), CITA-2000-6
Charged-particle decay and suppression of small-scale power
We study the suppression of the small-scale power spectrum due to the decay
of charged matter to dark matter prior to recombination. Prior to decay, the
charged particles couple to the photon-baryon fluid and participate in its
acoustic oscillations. However, after decaying to neutral dark matter the
photon-baryon fluid is coupled only gravitationally to the newly-created dark
matter. This generically leads to suppression of power on length scales that
enter the horizon prior to decay. For decay times of approximately 3.5 years
this leads to suppression of power on subgalactic scales, bringing the observed
number of Galactic substructures in line with observation. Decay times of a few
years are possible if the dark matter is purely gravitationally interacting,
such as the gravitino in supersymmetric models or a massive Kaluza-Klein
graviton in models with universal extra dimensions.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let
Complex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein
The β2–α2 loop of PrPC is a key modulator of disease-associated prion protein misfolding. Amino acids that differentiate mouse (Ser169, Asn173) and deer (Asn169, Thr173) PrPC appear to confer dramatically different structural properties in this region and it has been suggested that amino acid sequences associated with structural rigidity of the loop also confer susceptibility to prion disease. Using mouse recombinant PrP, we show that mutating residue 173 from Asn to Thr alters protein stability and misfolding only subtly, whilst changing Ser to Asn at codon 169 causes instability in the protein, promotes oligomer formation and dramatically potentiates fibril formation. The doubly mutated protein exhibits more complex folding and misfolding behaviour than either single mutant, suggestive of differential effects of the β2–α2 loop sequence on both protein stability and on specific misfolding pathways. Molecular dynamics simulation of protein structure suggests a key role for the solvent accessibility of Tyr168 in promoting molecular interactions that may lead to prion protein misfolding. Thus, we conclude that ‘rigidity’ in the β2–α2 loop region of the normal conformer of PrP has less effect on misfolding than other sequence-related effects in this region
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