Der einfluss von epsilon-aminokapronsaure (eaca) auf die plasma-gerinnungszeit

Man bestimmte die Gerinnungszeit einer Mischung von 0.1 ml des frischen Zitratplasmas, 0.1 ml einer Epsilon-Aminokaprons&#228;ure-L&#246;sung in Konzentrationen von 0, 02, 0.5, 2.5, 10, 20, 50 und 100 gamma, 0.1 ml CaCl&#178; L&#246;sung und 0.1 ml Michaelis' Puffer. Die erw&#228;hnten EACA-Konzentrationen hatten keinen charakteristischen Einfluss auf die Rekalzifikationszeit des frischen und des gel&#246;sten lyophilisierten Plasmas.</p

Inactivation de la thrombine par l'urine humaine normale.

Les urines humaines normales inactivent immédiatement la thrombine ajoutée quand leur pH est acide ou au moindre degré quand leur pH est a1calin. Quand le pH d'urine est neutral ou légerement alcalin l'inactivation de thrombine est faible ou s'annule. Après une incubation de 10 et 20 minutes de l'urine avec la thrombine l'inactivation ne subit pas de changements essentiaux. Les résultats obtenus in vitro démontrent que l'alcalinisation d'urine a l'aide d'une diète appropri&#233;s ou des remèdes pharmacologiques peuvent favorablement influencer les hémorragies imminentes ou d&#233;ja existantes du systeme urinaire.</p

Inactivation de la thrombine par l'urine humaine normale.

Les urines humaines normales inactivent immédiatement la thrombine ajoutée quand leur pH est acide ou au moindre degré quand leur pH est a1calin. Quand le pH d'urine est neutral ou légerement alcalin l'inactivation de thrombine est faible ou s'annule. Après une incubation de 10 et 20 minutes de l'urine avec la thrombine l'inactivation ne subit pas de changements essentiaux. Les résultats obtenus in vitro démontrent que l'alcalinisation d'urine a l'aide d'une diète appropri&#233;s ou des remèdes pharmacologiques peuvent favorablement influencer les hémorragies imminentes ou d&#233;ja existantes du systeme urinaire.</p

Comorbidity patterns in dual diagnosis across seven European sites

Background and Objectives: Psychiatric inpatients with substance use disorders are a significant public health concern due to grave consequences including increased risk of self harm, homicide as well as poor clinical outcome. The present study aims to examine and compare patterns of comorbidity (i.e. concurrent substance use disorders and severe mental illness) among psychiatric inpatients across seven European sites.Methods: 352 patients were included consecutively from psychiatric inpatients units at 7 European sites and interviewed with the Mini- International Neuropsychiatric Interview and the European version of the Addiction Severity Index questionnaires. For analysis the psychiatric diagnostic groups were organized into broader categories.Results: Concurrent alcohol use disorder and mood disorder was found to be the most prevalent comorbidity pattern (30.8%) across Europe. Alcohol or drug use disorder combined with mood disorder was most prevalent among females and in the older age group whereas mixed substance use and psychosis was more frequent among males and younger participants. Finally, differences in comorbidity patterns were found at different European sites.Conclusions: The prevalence of different comorbidity patterns varied across European clinical settings. Significant differences between comorbidity subgroups were found with regard to age and gender.</p

Comorbidity patterns in dual diagnosis across seven European sites

Background and Objectives: Psychiatric inpatients with substance use disorders are a significant public health concern due to grave consequences including increased risk of self harm, homicide as well as poor clinical outcome. The present study aims to examine and compare patterns of comorbidity (i.e. concurrent substance use disorders and severe mental illness) among psychiatric inpatients across seven European sites.Methods: 352 patients were included consecutively from psychiatric inpatients units at 7 European sites and interviewed with the Mini- International Neuropsychiatric Interview and the European version of the Addiction Severity Index questionnaires. For analysis the psychiatric diagnostic groups were organized into broader categories.Results: Concurrent alcohol use disorder and mood disorder was found to be the most prevalent comorbidity pattern (30.8%) across Europe. Alcohol or drug use disorder combined with mood disorder was most prevalent among females and in the older age group whereas mixed substance use and psychosis was more frequent among males and younger participants. Finally, differences in comorbidity patterns were found at different European sites.Conclusions: The prevalence of different comorbidity patterns varied across European clinical settings. Significant differences between comorbidity subgroups were found with regard to age and gender.</p

Predictors of service use of patients with co-morbid mental health and substance use disorders across seven European sites

The purpose of this study was to identify factors which predict service use over time in patients with co-morbid mental health and substance use disorders (dual diagnosis). Three hundred and fifty-two patients with dual diagnosis were recruited from acute psychiatric inpatient units at seven European sites. At baseline and 9 months follow-up, socio-demographic and clinical information, as well as information concerning the use of treatment services was collected. Predictors for use of psychiatric and substance misuse services at follow-up were studied using multinomial logistic regression models. At follow-up, patients with dual diagnosis used psychiatric services significantly more than substance use services. The main predictor of service use at follow-up is influenced by the study site and not by psychopathology. More networking and signposting are needed especially for substance misuse services. Service provision and planning can improve access of vulnerable populations even when psychopathology improves

Predictors of service use of patients with co-morbid mental health and substance use disorders across seven European sites

The purpose of this study was to identify factors which predict service use over time in patients with co-morbid mental health and substance use disorders (dual diagnosis). Three hundred and fifty-two patients with dual diagnosis were recruited from acute psychiatric inpatient units at seven European sites. At baseline and 9 months follow-up, socio-demographic and clinical information, as well as information concerning the use of treatment services was collected. Predictors for use of psychiatric and substance misuse services at follow-up were studied using multinomial logistic regression models. At follow-up, patients with dual diagnosis used psychiatric services significantly more than substance use services. The main predictor of service use at follow-up is influenced by the study site and not by psychopathology. More networking and signposting are needed especially for substance misuse services. Service provision and planning can improve access of vulnerable populations even when psychopathology improves