EBV in Hodgkin Lymphoma

Up to 40% of Hodgkin lymphoma (HL) cases are associated with the Epstein-Barr virus (EBV). Clonal viral genomes can be found in the HL tumor cells, the Hodgkin Reed-Sternberg cells (HRS). The latent infection results in expression of the viral oncogenes LMP1 and LMP2A which contribute to generate the particular phenotype of the HRS cells. EBV does not only undergo epigenetic changes of its genome during latency, but also induces epigenetic changes in the host genome. The presence of EBV may alter the composition and activity of the immune cells surrounding the HRS cells. EBV favours a Th1 reaction, but this attempt at a cell mediated immune response appears to be ineffective. The presence of EBV in HL is associated with several clinicopathological characteristics: It is more frequent in cases with mixed cellular histology, in males, in children and older adults, and in developing countries, while the young-adult onset HL of nodular sclerosis type in industrialized countries is typically EBV-negative. Countries in the Mediterranean area often show an intermediate epidemiological pattern. Recent studies suggest a genetic predisposition to develop EBV-associated HL. Circulating EBV-DNA may serve as a biomarker to monitor response to therapy, and eventually, EBV will become a target for therapeutic intervention also in HL

Matching Patterns with Variables Under Edit Distance

A pattern $\alpha$ is a string of variables and terminal letters. We say that $\alpha$ matches a word $w$, consisting only of terminal letters, if $w$ can be obtained by replacing the variables of $\alpha$ by terminal words. The matching problem, i.e., deciding whether a given pattern matches a given word, was heavily investigated: it is NP-complete in general, but can be solved efficiently for classes of patterns with restricted structure. If we are interested in what is the minimum Hamming distance between $w$ and any word $u$ obtained by replacing the variables of $\alpha$ by terminal words (so matching under Hamming distance), one can devise efficient algorithms and matching conditional lower bounds for the class of regular patterns (in which no variable occurs twice), as well as for classes of patterns where we allow unbounded repetitions of variables, but restrict the structure of the pattern, i.e., the way the occurrences of different variables can be interleaved. Moreover, under Hamming distance, if a variable occurs more than once and its occurrences can be interleaved arbitrarily with those of other variables, even if each of these occurs just once, the matching problem is intractable. In this paper, we consider the problem of matching patterns with variables under edit distance. We still obtain efficient algorithms and matching conditional lower bounds for the class of regular patterns, but show that the problem becomes, in this case, intractable already for unary patterns, consisting of repeated occurrences of a single variable interleaved with terminals

Matching Patterns with Variables Under Hamming Distance

A pattern ? is a string of variables and terminal letters. We say that ? matches a word w, consisting only of terminal letters, if w can be obtained by replacing the variables of ? by terminal words. The matching problem, i.e., deciding whether a given pattern matches a given word, was heavily investigated: it is NP-complete in general, but can be solved efficiently for classes of patterns with restricted structure. In this paper, we approach this problem in a generalized setting, by considering approximate pattern matching under Hamming distance. More precisely, we are interested in what is the minimum Hamming distance between w and any word u obtained by replacing the variables of ? by terminal words. Firstly, we address the class of regular patterns (in which no variable occurs twice) and propose efficient algorithms for this problem, as well as matching conditional lower bounds. We show that the problem can still be solved efficiently if we allow repeated variables, but restrict the way the different variables can be interleaved according to a locality parameter. However, as soon as we allow a variable to occur more than once and its occurrences can be interleaved arbitrarily with those of other variables, even if none of them occurs more than once, the problem becomes intractable

Combinatorial Algorithms for Subsequence Matching: A Survey

In this paper we provide an overview of a series of recent results regarding algorithms for searching for subsequences in words or for the analysis of the sets of subsequences occurring in a word.Comment: This is a revised version of the paper with the same title which appeared in the Proceedings of NCMA 2022, EPTCS 367, 2022, pp. 11-27 (DOI: 10.4204/EPTCS.367.2). The revision consists in citing a series of relevant references which were not covered in the initial version, and commenting on how they relate to the results we survey. arXiv admin note: text overlap with arXiv:2206.1389

Longest Common Subsequence with Gap Constraints

We consider the longest common subsequence problem in the context of subsequences with gap constraints. In particular, following Day et al. 2022, we consider the setting when the distance (i. e., the gap) between two consecutive symbols of the subsequence has to be between a lower and an upper bound (which may depend on the position of those symbols in the subsequence or on the symbols bordering the gap) as well as the case where the entire subsequence is found in a bounded range (defined by a single upper bound), considered by Kosche et al. 2022. In all these cases, we present effcient algorithms for determining the length of the longest common constrained subsequence between two given strings