sj-pdf-1-ajs-10.1177_03635465231162107 – Supplemental material for Long-term Assessment of Subchondral Bone Changes and Intralesional Bony Overgrowth After Third-Generation Autologous Chondrocyte Implantation: A Retrospective Study

Supplemental material, sj-pdf-1-ajs-10.1177_03635465231162107 for Long-term Assessment of Subchondral Bone Changes and Intralesional Bony Overgrowth After Third-Generation Autologous Chondrocyte Implantation: A Retrospective Study by Lukas Zak, Anne Kleiner, Siegfried Trattnig, Christian Albrecht and Silke Aldrian in The American Journal of Sports Medicine</p

Ratings of the three applied substances CO₂, menthol and cinnamaldehyde.

<p>^a Bonferroni corrected</p><p>^b High values indicate pleasant/ familiar stimuli</p><p>^c High values indicate painful stimuli</p><p>^d Percentage of subjects who were able to label the substance correctly</p><p>Ratings of the three applied substances CO₂, menthol and cinnamaldehyde.</p

Multiple regression analysis for cardiac index as depending variable; MYCL: myocardial lipid content.

<p>Multiple regression analysis for cardiac index as depending variable; MYCL: myocardial lipid content.</p

Anthropometric characteristics, laboratory parameters and data of magnetic resonance measurements; parameters of left ventricular (LV) myocardial function was normalized to body surface area using the Dubois-formula.

<p>Anthropometric characteristics, laboratory parameters and data of magnetic resonance measurements; parameters of left ventricular (LV) myocardial function was normalized to body surface area using the Dubois-formula.</p

Correlation analyses of pericardial fat (PERI) and myocardial fat (MYCL) with cardiac index and E/A ratio in all subjects.

<p>Correlation analyses of pericardial fat (PERI) and myocardial fat (MYCL) with cardiac index and E/A ratio in all subjects.</p

R-values of pericardial (PERI) and intramyocardial (MYCL) adipose tissue with parameters of systolic and diastolic left ventricular functional parameters using Pearson correlation analysis in all subjects.

<p>R-values of pericardial (PERI) and intramyocardial (MYCL) adipose tissue with parameters of systolic and diastolic left ventricular functional parameters using Pearson correlation analysis in all subjects.</p

Comparison of metabolic and cardiac parameters between the groups.

<p><b>a</b>) Myocardial lipid content (MYCL) was comparable between the groups: healthy controls (<b>CON</b>), pGDM with normal glucose tolerance (<b>NGT</b>), pGDM with impaired glucose regulation (<b>IGR</b>) and pGDM with overt type 2 diabetes (<b>T2DM</b>), while <b>b</b>) the Fatty Liver Index (FLI) increased along the GT-groups and was significantly increased in T2DM compared to CON; <b>c</b>) left-ventricular wall thickness was higher in T2DM compared to NGT and <b>d</b>) heart rate was highest in T2DM, being significantly different from NGT and CON.</p

Intramyocardial lipid- (MYCL, given in % of water signal [w. s.]) (a) and intrahepatic lipid concentration (IHCL, given in % of water signal [w. s.]) at baseline, day 10 of IT and during follow up (181±49 days) (b).

<p>Gray bars indicate IT-group and empty bar the OT-group; error bars delineate SEM.</p

Association between mean glucose concentrations at day 1 and MYCL content at day 10 of IT.

<p>Association between mean glucose concentrations at day 1 and MYCL content at day 10 of IT.</p

Correlation analysis.

<p><b>a</b>) Myocardial lipid content (MYCL) was positively correlated with the body mass index in CON and NGT and <b>b</b>) inversely associated with the ejection fraction in T2DM.</p