Pengaruh Pemberian Ekstrak Daun Cengkeh (Syzygium Aromaticum) Terhadap Gambaran Histopatologik Hati Tikus Wistar Yang Diberikan Parasetamol Dosis Toksik

: Clove (Syzygium aromaticum) contains eugenol, a phenolic compound, which has been suggested to possess antioxidant activity. This compound is suspected to be able to minimize damage to the liver cells caused by drugs such as paracetamol. This study aimed to observe the effects of clove leaf extract on histopathological features of Wistar rat liver tissue induced with toxic doses of paracetamol. This was an experimental laboratory study. Subjects were 24 male Wistar rats. The dose of clove leaf extract was 200 mg/day (single dose) and of paracetamol 50 mg/day (single dose) orally. Group A (negative control) was given no treatment for 14 days. Group B was given paracetamol for 14 days. Group C was given clove leaf extract for 7 days and then added with paracetamol for 7 days. Group D was given clove leaf extract and paracetamol simultaneously for 14 days. Group A showed normal histological feature of liver cells. Group B showed liver cell damage induced by paracetamol. Group C showed regeneration of liver cells, but there were still some necrosis and fatty liver cells. Group D showed regeneration of liver cells meanwhile cell necrosis was hardly found. Conclusion: Clove leaf extract could improve the histopathological changes of liver tissues of Wistar rats due to administration of paracetamol at toxic dose. This improvement was manifested as better regeneration of liver cells than that of rats not treated with clover leaf extract