Reverberation Time Control by Acoustic Metamaterials in a Small Room

In recent years, metamaterials have gained considerable attention as a promising material technology due to their unique properties and customizable design, distinguishing them from traditional materials. This article delves into the value of acoustic metamaterials in room acoustics, particularly in small room acoustics that poses specific challenges due to their significant cavity resonant nature. Small rooms usually exhibit an inhomogeneous frequency response spectrum, requiring higher wall absorption with specific spectrum to achieve a uniform acoustic environment, i.e., a constant reverberation time over a wide audible frequency band. To tackle this issue, we developed a design that simultaneously incorporates numerous subwavelength acoustic resonators at different frequencies to achieve customized broadband absorption for the walls of a specific example room. The on-site experimental measurements agree well with the numerical predictions, attesting to the robustness of the design and method. The proposed method of reverse-engineering metamaterials by targeting specific acoustic requirements has broad applicability and unique advantages in small confined spaces with high acoustic requirements, such as recording studios, listening rooms, and car cabins.Comment: 15 pages, 6 figure

Ratcheting of 316L stainless steel thin wire under tension-torsion loading

A series of cyclic tension-torsion tests under symmetric shear strain and asymmetric axial stress control in various loading paths are conducted on 100 ?m-diameter 316L steel wires applying a micro tensiontorsion fatigue testing apparatus. The ratcheting strain of the thin wire increases with increasing axial mean stress and decreases in a sequence of linear, rhombic and circular paths. The macro-scale based cyclic plastic constitutive models with kinematic hardening rules of the Ohno-Wang (OW) and the Chen-Jiao-Kim (C-J-K) are evaluated for the thin wire. Comparing with the O-W, the C-J-K predicts more accurately under high axial stress. While the loading path effects on ratcheting for wire specimens are basically simulated, the macro-based models tend to under-estimate the effect of phase difference between axial and torsional loadings and the ratcheting evolution in the initial 50 cycles.&nbsp

Regional Differential Information Entropy for Super-Resolution Image Quality Assessment

PSNR and SSIM are the most widely used metrics in super-resolution problems, because they are easy to use and can evaluate the similarities between generated images and reference images. However, single image super-resolution is an ill-posed problem, there are multiple corresponding high-resolution images for the same low-resolution image. The similarities can't totally reflect the restoration effect. The perceptual quality of generated images is also important, but PSNR and SSIM do not reflect perceptual quality well. To solve the problem, we proposed a method called regional differential information entropy to measure both of the similarities and perceptual quality. To overcome the problem that traditional image information entropy can't reflect the structure information, we proposed to measure every region's information entropy with sliding window. Considering that the human visual system is more sensitive to the brightness difference at low brightness, we take $\gamma$ quantization rather than linear quantization. To accelerate the method, we reorganized the calculation procedure of information entropy with a neural network. Through experiments on our IQA dataset and PIPAL, this paper proves that RDIE can better quantify perceptual quality of images especially GAN-based images.Comment: 8 pages, 9 figures, 4 table

Analysis of cognitive function and its related factors after treatment in Meniere’s disease

A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere’s disease (MD), a common clinical vestibular disorder, is usually accompanied by hearing loss and emotional stress, both of which may mediate the relationship between vestibule dysfunction and cognition. It is currently unknown whether the cognitive decline in MD patients could improve through treatment and how it relates to multiple clinical characteristics, particularly the severity of vertigo. Therefore, in the present study, the MD patients were followed up for 3, 6, and 12 months after treatment, and the cognitive functions, vertigo symptoms, and related physical, functional, and emotional effects of the patients were assessed using the Montreal Cognitive Assessment (MoCA) and Dizziness Handicap Inventory (DHI), aiming to explore the change in cognition before and after therapy and the correlation with various clinical features. It was found that cognitive decline in MD patients compared to healthy controls before therapy. Importantly, this cognitive impairment could improve after effective therapy, which was related to the severity of vertigo, especially in functional and physical impacts. Our results support the view that vestibular dysfunction is a potentially modifiable risk factor for cognitive decline

QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors

Andrographolide derivatives were shown to inhibit α-glucosidase. To investigate the relationship between activities and structures of andrographolide derivatives, a training set was chosen from 25 andrographolide derivatives by the principal component analysis (PCA) method, and a quantitative structure-activity relationship (QSAR) was established by 2D and 3D QSAR methods. The cross-validation r2 (0.731) and standard error (0.225) illustrated that the 2D-QSAR model was able to identify the important molecular fragments and the cross-validation r2 (0.794) and standard error (0.127) demonstrated that the 3D-QSAR model was capable of exploring the spatial distribution of important fragments. The obtained results suggested that proposed combination of 2D and 3D QSAR models could be useful in predicting the α-glucosidase inhibiting activity of andrographolide derivatives

Image Restoration Quality Assessment Based on Regional Differential Information Entropy

With the development of image recovery models, especially those based on adversarial and perceptual losses, the detailed texture portions of images are being recovered more naturally. However, these restored images are similar but not identical in detail texture to their reference images. With traditional image quality assessment methods, results with better subjective perceived quality often score lower in objective scoring. Assessment methods suffer from subjective and objective inconsistencies. This paper proposes a regional differential information entropy (RDIE) method for image quality assessment to address this problem. This approach allows better assessment of similar but not identical textural details and achieves good agreement with perceived quality. Neural networks are used to reshape the process of calculating information entropy, improving the speed and efficiency of the operation. Experiments conducted with this study’s image quality assessment dataset and the PIPAL dataset show that the proposed RDIE method yields a high degree of agreement with people’s average opinion scores compared with other image quality assessment metrics, proving that RDIE can better quantify the perceived quality of images

A Model of Interaction between Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Apocynin Analogues by Docking Method

Abstract: Some apocynin analogues have exhibited outstanding inhibition to NADPH oxidase. In this study, the key interactions between apocynin analogues and NADPH oxidase were analyzed by the docking method. The potential active site was first identified by the SiteID program combining with the key residue CYS378. Afterwards, the compounds in the training set were docked into NADPH oxidase (1K4U) under specific docking constraints to discuss the key interactions between ligands and the receptor. These key interactions were then validated by the consistence between the docking result and the experimental result of the test set. The result reveals that the Pi interaction between apocynin analogues and NADPH oxidase has a direct contribution to inhibition activities, except for H-bond formation and docking score. The key interactions might be valuable to discover and screen apocynin analogues as potent inhibitors of NADPH oxidase

An Efficient <i>Agrobacterium</i>-Mediated Genetic Transformation System for Persimmon (<i>Diospyros kaki</i> Thunb.)

Persimmon (Diospyros kaki Thunb.) is an important fruit crop in East Asia and has great commercial potential due to the high demand for fresh edible fruits or processed dried persimmon, as well as its being a source of raw materials for the chemical industry. Genetic engineering has shown great potential in persimmon fruit improvement and compensated for the limitations of conventional breeding. In this study, we developed an efficient transformation system and in vivo regeneration protocol by using the leaf disc culture of ‘Gongcheng Shuishi’ persimmon through the optimization of different basic media and hormone combinations. Based on the secondary induction system on 1/2DKW (DKW medium) + ZT (2.0 mg/L) + TDZ (0.5 mg/L) and MS (1/2 N) + ZT (2.0 mg/L) + IAA (0.1 mg/L), the callus induction rate and adventitious bud induction rate were 96.0% and 94.0%, respectively, and RNA interference of DkANR (ANR, anthocyanidin reductase) was achieved after transformation, thus resulting in a reduction in proanthocyanidin accumulation. The GFP (green fluorescent protein) fluorescence signal was visualized in the transgenic seedlings with GFP gene cotransformation. A total of 17.9% of the positive regenerated transgenic seedlings with empty vector were confirmed by both hyg gene and 35S promoter PCR analysis. Southern blotting assays showed that 20 positive transgenic persimmon seedlings were obtained from 135 regenerated transformants derived from DkANRi. Altogether, a reliable and highly efficient transformation system was achieved in persimmon, which may contribute to gene function identification and genetic improvement in the future

Comparative genomic analysis of Chinese human leptospirosis vaccine strain and circulating isolate

Leptospira interrogans serogroup Canicola is one of the most important pathogens causing leptospirosis and is used as a vaccine strain of the current Chinese human leptospirosis vaccine. To characterize leptospiral pathogens, L. interrogans serogroup Canicola vaccine strain 611 and circulating isolate LJ178 from different hosts at different periods were sequenced using a combined strategy of Illumina X10 and PacBio technologies, and a comprehensive comparative analysis with other published Leptospira strains was conducted in this study. High levels of genomic similarities were observed between vaccine strain 611 and circulating isolate LJ178; both had two circular chromosomes and two circular extrachromosomal replicons. Compared with the strain 611 genome, 132 single nucleotide polymorphisms and 92 indels were found in strain LJ178. The larger lipopolysaccharide biosynthesis locus of serogroup Canicola was identified in both genomes. The phylogenetic analysis based on whole-genome sequences revealed that serogroup Canicola was not restricted to a specific host or geographic location, suggesting adaptive evolution associated with the ecologic diversity. In summary, our findings provide insights into a better molecular understanding of the component strains of human leptospirosis vaccine in China. Furthermore, these data detail the genetic composition and evolutionary relatedness of Leptospira strains that pose a health risk to humans