13 research outputs found
Serologic investigation for bluetongue virus type 4, 9 and 16 in Anatolian water buffaloes
THE VALIDATION OF THE PEDIATRIC INCONTINENCE QUESTIONNAIRE (PINQ): A QUALITY OF LIFE MEASUREMENT SPECIFIC TO CHILDREN WITH BLADDER DISFUNCTION IN TURKEY
WOS: 000443998400156
INFLUENCE OF PERITONEAL TRANSPORTCHARACTERISTICS ON CLINICAL OUTCOME INCHILDREN WITH PERITONEAL DIALYSIS
Could mini-PET be used to instead of 4 h original-PET to assess peritoneal permeability in children on peritoneal dialysis?
Background: Original peritoneal equilibration test (PET) is an implementation that requires hard work for peritoneal dialysis (PD) staff. Therefore, several authors have attempted to validate short and fast PET protocols, with controversial results. The aim of this study was to evaluate the concordance between the mini-PET and original PET in children. Methods: In 26 stable continuous ambulatory PD patients, we performed an original PET with 2.27% (4 h) and a mini-PET with 3.86% glucose PD fluid (1 h) and compared ultrafiltration (UF) and small solute transports obtained with the two methods. Results: Twenty-six children, 14 males, mean age 11.4 +/- 5.6 (range 2.5-19 years), were included. Meantime on PD at time of enrollment was 35.2 +/- 24.5 months (range 6-84 months). Based on the 4-h creatinine D/P data, the number of the patients within each transport category was as follow: high, 5; average, 18; low, 3. Kappa test showed a significant concordance between original PET and mini-PET (k = 0.610). Based on the 4-h glucose D/D-0 data, the number of the patients within each transport category was as follow: high, 5; average, 17; low, 4. Kappa test showed a moderate agreement between original PET and mini-PET (0.514, p = 0.000). When Pearson correlation analysis between original PET and mini-PET was performed, there were significant positive correlations between original 2.27% PET and mini-PET (r = 0.720, p = 0.000, r = 0.638, p = 0.000, respectively). When comparing the numeric results of mini-PET and 4 h of original PET for D/C-reatinine, by simple regression analysis, we found statistically significant correlation among PETs. Conclusions: In this study, we showed concordance between the mini-PET and original PET. The 3.86% mini-PET is simple and fast methods to assess free water transport. This also gives information about total UF and small solute transports and it is in good agreement with the original PET
Effectiveness of melatonin in preventing vancomycin-induced nephrotoxicity: an experimental study
Purpose: The aim of the study explores probable toxic effects of vancomycin on kidney and analysis of the probable protective effects of melatonin
Periton diyalizi yapılan çocuklarda periton geçirgenliğini değerlendirmek için standart PET yerine mini PET ve/veya double mini PET kullanılabilir mi?
Investigating Hemolytic Activity of Candida Isolates with Two Different Methods
The hemolytic activity of Candida isolates with agar and microplate methods were investigated and compared efficiency of these methods to assess relationship between hyphal formation and hemolysis
The Validation of the Pediatric Incontinence Questionnaire (PINQ) : A Quality of Life Measurement Specific to Children With Bladder Disfunction in Turkey
Suberosin Alleviates Sepsis-Induced Lung Injury in A Rat Model of Cecal Ligation and Puncture
Background/aims Sepsis is one of the major problems encountered in intensive care units, causing organ damage and increasing mortality. Suberosin (SBR) is a type of coumarin with antioxidant and anti-inflammatory activities. The goal of this study is to explore the protective effects of SBR on the lungs in a rat model of sepsis. Methods Male Wistar rats were utilized in this study. A cecal ligation and puncture (CLP) model was applied to induce sepsis. Rats were separated into six groups with nine animals in each group, including healthy control, SBR, CLP, and CLP + SBR (5, 10, and 20 mg/kg) groups. Superoxide dismutase (SOD), glutathione (GSH) enzyme activities, and malondialdehyde (MDA) level were measured via enzyme-linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expressions of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) were evaluated by real-time polymerase chain reaction (RT-PCR). Histopathological changes in the lungs were investigated with hematoxylin and eosin (H&E). Results MDA levels and GSH and SOD enzyme activities were negatively affected in the CLP group, but SBR treatment ameliorated these oxidative stress parameters in the SBR1-3 groups (p< 0.05). The mRNA expressions of TNF-α and IL-1β were increased in the CLP group, and SBR treatment decreased those expression levels in a dose-dependent manner (p < 0.05). Organ damage and necrosis were seen in the CLP group and were alleviated in the SBR3 group. Immunohistochemical (IHC) analysis of lung tissues demonstrated decreased TNF-α and IL-1β immunopositivity in the SBR1-3 groups (p< 0.05). Conclusions SBR ameliorated sepsis-related lung injury in a dose-dependent manner. This compound has significant potential as a future agent in the treatment of sepsis