Clinicopathologic Characteristics of Multifocal Gastric Adenocarcinoma

BACKGROUNDANDOBJECTIVE: Gastric cancer is the fifth prevalent cancer in worldwide. Among of this, adenocarcinoma is more than 95% of all case and most prevalent. According to gastric adenocarcinoma is resistant to adjuvant therapy, surgical resection is the cardinal strategies of treatment. One of the problems with treating adenocarcinoma of the stomach is that its main causes are malignant or pre-malignant changes in the residual gastric tissue that may be neglected during resection. By recognizing these lesions and resection, they can be expected to reduce the malignancy. Therefore, this study was conducted to investigate the characteristics of non-tumoral gastric tissue in terms of malignant or pre-malignant changes. METHODS: In this retrospective cross-sectional study, 112 patients who had undergone total gastrectomy in the hospitals affiliated to Babol University of Medical Sciences during the period of 2013-2017 were examined and analyzed for age, sex, type and location of tumor. FINDINGS: Of 112 cases that studied,72 cases (64.3%) were male and 40 cases (35.7%) were female. The mean of ages was 64.7±8.6 year. Poorly differentiated pathology in 60.7% and well differentiated pathology in 39.3% of patients were seen. In 64 patients (57%), there was synchronous lesions in addition to primary pathology. These synchronous lesions were related statistically significant to pathology, cancer stage and gender. CONCLUSION: Based on the results of this study, it can be concluded that resection should be accompanied by considering simultaneous lesions in addition to primary pathology, which can be a reason for total gastrectomy as a standard treatment for gastric cancer

Correlation of Tissue Eosinophils with Prognosis in Head and Neck Cutaneous Squamous Cell Carcinomas

BACKGROUND AND OBJECTIVE: The skin squamous cell carcinoma (CSCC) is the second most common skin cancer. The correlation between severe tissue eosinophilia with optimal and undesirable prognosis, or even an ineffectiveness effect was related. The aim of the present study was to investigate the correlation between tissue eosinophilia and prognosis in patients with head and neck squamous cell carcinoma. METHODS: In this cross-sectional study, 33 patients with squamous cell carcinoma of the pathology department of Shahid Beheshti hospital of University of Babol University of Medical Sciences (age, sex, tumor site) were collected and histopathologic in the vascular and nervous invasions was studied. Numbers of eosinophils (eos.) were counted in 15 successive fields at invasive fronts of HNCSCCs (area of 15 fields=1.2mm2) at×400 magnification with optical microscope. The correlation between the mean number of eosinophils per Mm² and the severity of eosinophilia (mild and severe) and clinical-histopathologic factors was analyzed. FINDINGS: Mean eos/mm2 was 99.1913±104.39897. Overall survival rate, disease-specific survival rate and disease-free survival rate were %72.72, %61.53% and %84.84, respectively. There was inverse significant correlation between disease-free survival with eos/mm2 (p=0.043). There were no significant correlation between other clinical-histopathologic factors with mean eos/ mm2.There were inverse significant correlations between 5-year overall survival rate and 5-year disease-free survival rate with severity of tissue eosinophilia (p=0.02 and 0.013 respectively).There were not significant correlations between 5-year disease-specific survival and other factors with severity of tissue eosinophilia. CONCLUSION: There was inverse correlation between severity of tissue eosinophilia with survival

High-Risk and Low-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma at Mazandaran, Northern Iran

Cancers are the second most common cause of nonaccidental deaths in Iran, following cardiovascular deaths. Mazandaran, near the Caspian Littoral at north of Iran have identified as a several-high incidence area for Esophageal Squamous Cell Carcinoma (ESCC) in the world. Several associated risk factors, such as dietary and cultural habits, infectious agents, nutritional deficiencies, too much use of tobacco and alcohol and infection to certain DNA tumor viruses (HPVs), including environmental and genetic factors are attributed to this disease. To explore this issue, we analyzed HPV DNA prevalence and HPV types together in relation to tumor sites a high-incidence population. Archived tissue blocks from 46, 69 and 62 upper, middle and lower third of esophagus, respectively from ESCC patients were evaluated for the presence of HPV DNA by PCR using the degenerate HPV L1 consensus primer pairs MY09/MY11. The positive specimens were evaluated by Real-time PCR to determine HPV genotypes. From the 49 HPV positive cases, of ESCC patients, 5 (23.1%), 11 (55 %) and 9 (56.3 %) of upper, middle and lower third of ESCC specimens, respectively were positive by at least one high and one low-risk HPV genotypes. In general, HPV45 and HPV11 were the most common high- risk and low-risk HPV genotypes in HPV L1 positive cases, respectively, followed by HPV6, HPV52 and HPV39. Therefore, the high prevalence of HPV DNA in different anatomical sites of ESCC patients from the Mazandaran region in North of Iran provides more evidence for a role of HPV in this cancer

The Prevalence of Odontogenic Cysts and Tumors in Babol, North of Iran

BACKGROUND AND OBJECTIVE: Odontogenic cysts and tumors exclusively develop in the jaws from odontogenesis tissues. Given the importance of the early diagnosis and proper treatment, the present study aimed to determine the prevalence of these lesions in a population from the North of Iran during a 22-year survey. METHODS: This cross-sectional study was conducted by investigating the records in the archives of Shahid Beheshti Hospital of Babol affiliated with the Department of Pathology of School of Dentistry from 1990 to 2012. The demographic features of the subjects including age, gender, anatomic pathology and clinical and pathological lesions were collected in the form of data which were recorded and evaluated. FINDINGS: Out of a total of 8956 samples with oral lesion dysfunctions, 317 cases of odontogenic cysts and 53 cases of odontogenic tumors were discovered which belonged to 205 men (55.4%) and 165 women (44.6%). The mean age of these patients was 15.15 ± 28.75 years (ranging from 2 to 79 years). Among the cysts, radicular cyst accounted for the highest prevalence (67.8%) while ameloblastoma was the most frequent odontogenic tumor (82.6%). Moreover, the lesions most commonly developed in the maxillary anterior and the posterior mandibular region, respectively. CONCLUSION: According to the results of this study, the incidence of odontogenic tumors is lower compared to the incidence of odontogenic cysts in the north of Ira

Types of Pathological Lesions in Breast Cancer in Babol Over 10 Years (2008 – 2017)

BACKGROUND AND OBJECTIVE: Breast cancer is the most common cause of death from cancer in women worldwide. A comprehensive study of breast cancer in different parts of a country can provide the information for evidence-based planning and, consequently, cost reduction for both the patient and the society. The aim of this study was to investigate the types of pathological lesions in cases of breast cancer diagnosed in Babol (a city in the north of Iran) over 10 years. METHODS: In this cross-sectional study, all pathological reports on breast cancer that were recorded in Babol's pathology centers from 2008 to 2017 were studied. Demographic data, age of first menstruation, age of menopause, age of first delivery, history of breast cancer, history of ovarian and uterine cancer, history and duration of breastfeeding were collected and evaluated. FINDINGS: In this study, the frequency of breast cancer among diagnosed cases of cancer was reported to be 22.4%. 331 patients (99.1%) were female and 3 patients (0.9%) were male. 41.3% were in the age group of 41 – 50 years old. 26 patients (7.7%) had a history of breast cancer and 34 patients (10.1%) had a family history of breast cancer. 287 (85.9%) women had a history of breastfeeding. Ductal carcinoma was reported in 267 patients (79.9%). CONCLUSION: According to the results of this study, ductal carcinoma was reported as the most common type of pathology

Determination Of Appropriate Antibiotic In Bacterial Meningitis Of Children Based On MIC

Background: Bacterial meningitis is one of the most serious infections in infants and children. Three organisms include S.Pneumo;N.mening;H.Influ are the most common cause of meningitis in children between 2M-14y age.Etest is a new method for determination the MIC of some antimicrobial drugs in agarose .This method is useful for some organisms like as S .Pneumo; N.mening; H.Influ;sensitive Streptococcus and anaerobic ;aerobic gram negative. Materials and Methods: In this descriptive cross sectional study; In 57 suspected meningitis children ; organisms isolated from blood; CSF or other sterile boy fluid after culturing and antibiogram;. .MIC of someorganisms detected by Etest method. Results: Streptococcuswas the most prevalent ( 70%) and S.pneumon( 90% of all Streptococcus); H.infl 2%;N.mening 4%and L.monocyt 6%(more than expected);Gram negative (Ecoli; Klebsiella; entrobacter and psudomona) 18%. There was significant difference (P =0.01)in type of organisms between age groups. S.pneumonia was more frequent in children > 2 year ;N.meningitis in>4yr old .Site of isolation :blood; CSF (35.8*;28.3%)other sterile site 18.4%;concomitant positive culture in two site:17%.Mean age in Streptococcus was significantly different with Listeria (p=0.05); N.meningitis (p=0.04);H.influ (p=0.04);.but no difference with Staphylococcus;Klebsiella and E.coli Two type of H.inf were sensitive to Ampici or chloram ;both of them were sensitive to ceftiaxon. GBS were sensitive to PNC or Ampici Strep.nonAnonBnon- Cotrimoxazol>32mic/ml /PNC >256mic/ml/ Vanco>256mic/ml Strep.D: Cotrimoxazol>0.062mg/ml/ /PNC >0.016mic/ml/Imipenem>0.032mic/ml. Strep Pneumonia: All fo them were sensitive except 3 cases /Cotrimoxazol>2ic/ml /PNC =0.01mic/ml/Vanco>0.125mic/ m Vanco>0. 25mic/ ml/.Cotrimoxazol>2ic/ml / PNC =0.01mg/ml Vanco>0.125mic/ ml / Cotrimoxazol>2mic/ml /MIC-PNC >0.016mic/ml Therefore high dose of PNC is adequate for S.pneu ;because of Interm resistance to PNC All 3 N.menin were sensitive to PNC;Chlora;Ceftria and vanco Resistant to all drugs and high MIC for cefotaxime;CIPRO>32mic/ml. E coli: Pseudomona Aerogenosa:: Ceftriaxon>256mic/ml/ /Genta>0.038mg/ml Imipenem>32mic/ml. Klebsiella; only Sensitive to Cipro Staph .Aureous:Sensitive to Clinda;Cipro;Chlora;Resistant toCeft;PNCand Cotri Conclusion: Most type of N.meningitidis;H.inf and S.pneumonia were sensitive to many drugs. Only minority of them were resistant to Ampicillin but sensitive to chloramphenicol and vice versa. limited number of pneumococcal resistance to penicillin is medium resistance( MIC:0.1-1) .we can treat this resistant type by increasing of penicillin dosage .The others were sensitive to all drugs. Therefore ampicillin and chloramphenicol are the drug of choice in empiric treatment of bacterial meningitis after neonatal period