TDT: Teaching Detectors to Track without Fully Annotated Videos

Recently, one-stage trackers that use a joint model to predict both detections and appearance embeddings in one forward pass received much attention and achieved state-of-the-art results on the Multi-Object Tracking (MOT) benchmarks. However, their success depends on the availability of videos that are fully annotated with tracking data, which is expensive and hard to obtain. This can limit the model generalization. In comparison, the two-stage approach, which performs detection and embedding separately, is slower but easier to train as their data are easier to annotate. We propose to combine the best of the two worlds through a data distillation approach. Specifically, we use a teacher embedder, trained on Re-ID datasets, to generate pseudo appearance embedding labels for the detection datasets. Then, we use the augmented dataset to train a detector that is also capable of regressing these pseudo-embeddings in a fully-convolutional fashion. Our proposed one-stage solution matches the two-stage counterpart in quality but is 3 times faster. Even though the teacher embedder has not seen any tracking data during training, our proposed tracker achieves competitive performance with some popular trackers (e.g. JDE) trained with fully labeled tracking data.Comment: Workshop on Learning with Limited Labelled Data for Image and Video Understanding (L3D-IVU), CVPR2022 Worksho

Static Recrystallization Behavior and Texture Evolution during Annealing in a Cold Rolling Beta Titanium Alloy Sheet

In this study, the cold rolling microstructure and static recrystallization mechanism of the high strength titanium alloy Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe were systematically investigated. Results show that the cold rolling microstructure is mainly composed of the elongated deformed β grains containing micro-shear bands. After annealing at 815 °C for 2 min, the fine SRXed grains are observed, mainly concentrated in the micro-shear band, the grain boundary and the interior of the deformed grain. The sub-grain structure obtained by static recovery inside the deformed grain produces continuous SRX during the annealing treatment. Meanwhile, geometric and discontinued SRXed grains are also observed in the large deformed β grain and at the trigeminal grain boundaries, respectively. Many ultra-fine grains appear inside the micro-shear band, exhibiting a phenomenon of the micro-shear band assisting SRX. With the increase in the annealing holding time, the elongated β grains are significantly refined and the degree of recrystallization is continuously improved. In addition, the recrystallization behavior also results in a significant change in the fiber texture. With the extension of the annealing holding time, the rolling texture type evolves gradually, with the {111} γ-fiber texture to weak α-fiber, γ-fiber, and Goss-fiber

Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

Abstract To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and progression because of their versatile roles in extracellular matrix remodeling, maintenance of stemness, blood vessel formation, modulation of tumor metabolism, immune response, and promotion of cancer cell proliferation, migration, invasion, and therapeutic resistance. CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming growth factor-beta, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin, mitogen-activated protein kinase, Wnt, Janus kinase/signal transducers and activators of transcription, epidermal growth factor receptor, Hippo, and nuclear factor kappa-light-chain-enhancer of activated B cells, etc., signaling pathways. These signals in CAFs exhibit their own special characteristics during the cancer progression and have the potential to be targeted for anticancer therapy. Therefore, a comprehensive understanding of these signaling cascades in interactions between cancer cells and CAFs is necessary to fully realize the pivotal roles of CAFs in cancers. Herein, in this review, we will summarize the enormous amounts of findings on the signals mediating crosstalk of CAFs with cancer cells and its related targets or trials. Further, we hypothesize three potential targeting strategies, including, namely, epithelial–mesenchymal common targets, sequential target perturbation, and crosstalk-directed signaling targets, paving the way for CAF-directed or host cell-directed antitumor therapy

Experimental study of the flow dynamics and thermodynamic properties of a tube in vertical falling film evaporator for data center cabinets

This study presents an innovative integrated structure that combines a cabinet with a vertical falling film evaporator, enabling efficient natural evaporative cooling and effectively reducing energy loss in data centers. To in-depth understand the proposed structure's cooling mechanism, a novel inserted liquid film distributor is initially devised in the experiment, which can make the water flowing into the tube form an intact liquid film. Then, the visualization experiments are carried out in the tube to observe the water film flow dynamics, demonstrating that a minimum spray density of 0.048 kg·m−1·s−1 can be attained while maintaining liquid film integrity. Meanwhile, when the vibration frequency reaches 2700 Hz, a significant water film rupture in the tube occurs. Finally, building upon the experimental result analysis, at a spray density increment of 0.024 kg·m−1·s−1, the maximum increments of heat transfer rate and heat transfer coefficient corresponding to the intact liquid film are 16.2% and 23.3%, respectively. By contrast, those two indexes corresponding to the ruptured liquid film are 63.4% and 50.9%, respectively. This research provides reliable guidance and valuable insights for the design and efficient operation of natural evaporation falling film evaporators

Investigation of the Deformation Mechanism of a near β Titanium Alloy through Isothermal Compression

This study investigated the hot deformation behavior of Ti-4Al-1Sn-2Zr-5Mo-8V-2.5Cr alloy through isothermal compression tests at temperatures from 780 to 930 °C with strain rates ranging from 0.001 to 1 s−1. The flow stress decreases with a decreased strain rate and an increased temperature. A constitutive equation was established for this alloy and the dependence of activation energy on temperature and strain rate is discussed. We further proposed a processing map using the dynamic materials model. On the processing map various domains of flow stability and flow instability can be identified. The deformation mechanisms associated with flow stability regions are mainly dynamic recrystallization (DRX) and dynamic recovery (DRV). The flow instability is manifested in the form of the band of flow localizations. The optimum processing conditions are suggested such that the temperature range is from 780 to 880 °C and the strain rate ranges from 0.001 to 0.01 s−1

Protective Immunity against <i>Chlamydia psittaci</i> Lung Infection Induced by a DNA Plasmid Vaccine Carrying <i>CPSIT_p7</i> Gene Inhibits Dissemination in BALB/c Mice

Chlamydia psittaci (C. psittaci), a zoonotic pathogen, poses a potential threat to public health security and the development of animal husbandry. Vaccine-based preventative measures for infectious diseases have a promising landscape. DNA vaccines, with many advantages, have become one of the dominant candidate strategies in preventing and controlling the chlamydial infection. Our previous study showed that CPSIT_p7 protein is an effective candidate for a vaccine against C. psittaci. Thus, this study evaluated the protective immunity of pcDNA3.1(+)/CPSIT_p7 against C. psittaci infection in BALB/c mice. We found that pcDNA3.1(+)/CPSIT_p7 can induce strong humoral and cellular immune responses. The IFN-γ and IL-6 levels in the infected lungs of mice immunized with pcDNA3.1(+)/CPSIT_p7 reduced substantially. In addition, the pcDNA3.1(+)/CPSIT_p7 vaccine diminished pulmonary pathological lesions and reduced the C. psittaci load in the lungs of infected mice. It is worth noting that pcDNA3.1(+)/CPSIT_p7 suppressed C. psittaci dissemination in BALB/c mice. In a word, these results demonstrate that the pcDNA3.1(+)/CPSIT_p7 DNA vaccine has good immunogenicity and immunity protection effectiveness against C. psittaci infection in BALB/c mice, especially pulmonary infection, and provides essential practical experience and insights for the development of a DNA vaccine against chlamydial infection