MOSE: A New Dataset for Video Object Segmentation in Complex Scenes

Video object segmentation (VOS) aims at segmenting a particular object throughout the entire video clip sequence. The state-of-the-art VOS methods have achieved excellent performance (e.g., 90+% J&F) on existing datasets. However, since the target objects in these existing datasets are usually relatively salient, dominant, and isolated, VOS under complex scenes has rarely been studied. To revisit VOS and make it more applicable in the real world, we collect a new VOS dataset called coMplex video Object SEgmentation (MOSE) to study the tracking and segmenting objects in complex environments. MOSE contains 2,149 video clips and 5,200 objects from 36 categories, with 431,725 high-quality object segmentation masks. The most notable feature of MOSE dataset is complex scenes with crowded and occluded objects. The target objects in the videos are commonly occluded by others and disappear in some frames. To analyze the proposed MOSE dataset, we benchmark 18 existing VOS methods under 4 different settings on the proposed MOSE dataset and conduct comprehensive comparisons. The experiments show that current VOS algorithms cannot well perceive objects in complex scenes. For example, under the semi-supervised VOS setting, the highest J&F by existing state-of-the-art VOS methods is only 59.4% on MOSE, much lower than their ~90% J&F performance on DAVIS. The results reveal that although excellent performance has been achieved on existing benchmarks, there are unresolved challenges under complex scenes and more efforts are desired to explore these challenges in the future. The proposed MOSE dataset has been released at https://henghuiding.github.io/MOSE.Comment: MOSE Dataset Repor

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

TNF receptor–associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-κB (RANK). This event is central to normal osteoclastogenesis. We discovered that TRAF6 also interacts with FHL2 (four and a half LIM domain 2), a LIM domain–only protein that functions as a transcriptional coactivator or corepressor in a cell-type–specific manner. FHL2 mRNA and protein are undetectable in marrow macrophages and increase pari passu with osteoclast differentiation in vitro. FHL2 inhibits TRAF6-induced NF-κB activity in wild-type osteoclast precursors and, in keeping with its role as a suppressor of TRAF6-mediated RANK signaling, TRAF6/RANK association is enhanced in FHL2(–/–) osteoclasts. FHL2 overexpression delays RANK ligand–induced (RANKL-induced) osteoclast formation and cytoskeletal organization. Interestingly, osteoclast-residing FHL2 is not detectable in naive wild-type mice, in vivo, but is abundant in those treated with RANKL and following induction of inflammatory arthritis. Reflecting increased RANKL sensitivity, osteoclasts generated from FHL2(–/–) mice reach maturation and optimally organize their cytoskeleton earlier than their wild-type counterparts. As a consequence, FHL2(–/–) osteoclasts are hyperresorptive, and mice lacking the protein undergo enhanced RANKL and inflammatory arthritis–stimulated bone loss. FHL2 is, therefore, an antiosteoclastogenic molecule exerting its effect by attenuating TRAF6-mediated RANK signaling

Competing within and beyond the boundary: Joint effect of intergroup and intragroup competitions on group creativity

Group creativity is affected by both intergroup competition and intragroup competition, but few studies have examined their joint effect. Based on the Motivated Information Processing in Groups (MIP-G) model, the current study aims to explore such joint effects on group idea generation and idea selection. Both intergroup competition (high vs. low) and intragroup competition (competition vs. cooperation) were experimentally manipulated, and 66 three-person groups were randomly assigned to one of the four conditions to perform a brainstorming task. Consistent with our hypotheses, results showed that two types of competitions interacted to determine group idea generation in that groups under the high intergroup competition and intragroup cooperation condition were most creative in terms of fluency and flexibility. Regardless of the level of intergroup competition, groups demonstrated a higher level of idea elaboration under intragroup cooperation but not competition conditions. Moreover, intergroup and intragroup competitions complemented each other in terms of originality in idea generation and idea selection. Specifically, groups under intragroup competition (rather than intragroup cooperation) condition generated and selected ideas of higher originality when the intergroup competition was low; instead, when the intergroup competition was high, the originality of generated or selected ideas was higher for groups under intragroup cooperation condition. We concluded with a discussion of the implications and value of these findings for theoretical research and management practice in organizations.</p

Multiple soliton solutions, lump, rogue wave and breather solutions of high dimensional equation for describing Rossby waves

In the past, we haven't paid much attention to higher-dimensional models, which are actually more consistent with the real atmosphere. In this manuscript, we derive a high-dimensional Kadomtsev-Petviashvili equation from a fluid system based on the Gardner-Morikawa transformation and the small parameter perturbation method, which is the first time to characterize the propagation process of Rossby waves in Large-scale atmospheric. The exact solutions such as soliton, lump, rogue wave and breather of this equation are achieved according to Hirota bilinear method and symbolic computation approach. Further we utilize the composite diagram of these solutions to observe the propagation properties of Rossby waves with assistance of Mathematica. The results enrich the analysis of Rossby waves in marine engineering and fluid dynamics

Ultrasensitive Ambient Mass Spectrometry Immunoassays: Multiplexed Detection of Proteins in Serum and on Cell Surfaces

The sensitive and accurate determination of multiple protein biomarkers for clinical diagnosis is in high demand. Here, an ambient mass spectrometry immunoassay platform that possesses advantages of high sensitivity, multiplexed quantitation, low sample consumption and convenient operation was established. A series of extensible rhodamine-based mass tags that ensured quantification of multiple proteins with ultrahigh sensitivity through two-stage signal amplification were developed. Thrombin was detected at zeptomole sensitivity in 2 mu L serum/plasma, as was free cancer antigen 125 (CA125). Three protein biomarkers (CA125, carcinoembryonic antigen, and epithelial cell adhesion molecule) were simultaneously detected in situ on ca. 20 cells. This platform is promising for multiple protein detection in a single drop of sample or at the single-cell scale for clinical diagnosis and therapy

Access to quinolines through gold-catalyzed intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes

A facile and general method leading to polyfunctionalized quinolines was developed. In the presence of a highly efficient combination encompassing (PPh)3AuCl and AgOTf, the reactions between 2-aminocarbonyls and an array of internal alkynes proceeded smoothly to afford quinoline derivatives in good to excellent yields (up to 93%)

Spatio-Temporal Dynamics of Maize Potential Yield and Yield Gaps in Northeast China from 1990 to 2015

Maize yield has undergone obvious spatial and temporal changes in recent decades in Northeast China. Understanding how maize potential yield has changed over the past few decades and how large the gaps between potential and actual maize yields are is essential for increasing maize yield to meet increased food demand in Northeast China. In this study, the spatial and temporal dynamics of maize potential yield in Northeast China from 1990 to 2015 were simulated using the Global Agro-ecological Zones (GAEZ) model at the pixel level firstly. Then, the yield gaps between actual and potential yields were analyzed at city scale. The results were the following. (1) The maize potential yield decreased by about 500 kg/ha and the potential production remained at around 260 million tonnes during 1990&#8211;2000. From 2000 to 2015, the maize potential yield and production increased by approximately 1000 kg/ha and 80 million tonnes, respectively. (2) The maize potential yield decreased in most regions of Northeast China in the first decade, such as the center area (CA), south area (SA), southwest area (SWA), and small regions in northeast area (NEA), due to lower temperature and insufficient rainfall. The maize potential yield increased elsewhere. (3) The maize potential yield increased by more than 1000 kg/ha in the center area (CA) in the latter 15 years, which may be because of the climate warming and sufficient precipitation. The maize potential yield decreased elsewhere and Harbin in the center area (CA). (4) In 40 cities of Northeast China, the rates of actual yield to potential yield in 17 cities were higher than 80%. The actual yields only attained 50&#8211;80% of the potential yields in 20 cities. The gaps between actual and potential yields in Hegang and Dandong were very large, which need to be shrunk urgently. The results highlight the importance of coping with climate change actively, arranging crop structure reasonably, improving farmland use efficiency and ensuring food security in Northeast China

Evaluating Ecosystem Services and Trade-Offs Based on Land-Use Simulation: A Case Study in the Farming&ndash;Pastoral Ecotone of Northern China

Evaluating the impacts of land-use change (LUC) on ecosystem services (ESs) is necessary for regional sustainable development, especially for the farming&ndash;pastoral ecotone of northern China (FPENC), an ecologically sensitive and fragile region. This study aimed to assess the impacts of LUC on the ESs and provide valuable information for regional planning and management in the FPENC. To accomplish this, we assessed LUC in the FPENC from 2010 to 2020 and simulated land-use patterns in 2030 under three plausible scenarios: the business as usual scenario (BAUS), economic development scenario (EDS), and ecological protection scenario (EPS). Then, we quantified five ESs (including crop production, water yield, soil retention, water purification, and carbon storage) for 2020&ndash;2030 and analyzed the trade-offs and synergies among ESs in all scenarios. The results show that FPENC experienced expanding farming land and built-up land throughout 2010&ndash;2020. Under the BAUS and EDS from 2000 to 2030, especially EDS, the increase in farming land and built-up land will continue. As a result, crop production and water yield will increase, while soil retention, water purification, and carbon storage will decrease. In contrast, EPS will increase soil retention, water purification, and carbon storage at the cost of a decline in crop production and water yield. These results can provide effective reference information for future regional planning and management in the farming&ndash;pastoral ecotone

Evaluating Ecosystem Services and Trade-Offs Based on Land-Use Simulation: A Case Study in the Farming–Pastoral Ecotone of Northern China

Evaluating the impacts of land-use change (LUC) on ecosystem services (ESs) is necessary for regional sustainable development, especially for the farming–pastoral ecotone of northern China (FPENC), an ecologically sensitive and fragile region. This study aimed to assess the impacts of LUC on the ESs and provide valuable information for regional planning and management in the FPENC. To accomplish this, we assessed LUC in the FPENC from 2010 to 2020 and simulated land-use patterns in 2030 under three plausible scenarios: the business as usual scenario (BAUS), economic development scenario (EDS), and ecological protection scenario (EPS). Then, we quantified five ESs (including crop production, water yield, soil retention, water purification, and carbon storage) for 2020–2030 and analyzed the trade-offs and synergies among ESs in all scenarios. The results show that FPENC experienced expanding farming land and built-up land throughout 2010–2020. Under the BAUS and EDS from 2000 to 2030, especially EDS, the increase in farming land and built-up land will continue. As a result, crop production and water yield will increase, while soil retention, water purification, and carbon storage will decrease. In contrast, EPS will increase soil retention, water purification, and carbon storage at the cost of a decline in crop production and water yield. These results can provide effective reference information for future regional planning and management in the farming–pastoral ecotone

Transalveolar sinus floor lift without bone grafting in atrophic maxilla: A meta-analysis

Abstract We performed a meta-analysis aimed to assess the clinical results after transalveolar sinus floor lift without bone grafting in the atrophic maxilla. A systematic electronic literature search was conducted in PubMed, Embase and The Cochrane Library, followed by a manual search. Two reviewers independently extracted study data and conducted quality assessments. Ten non-controlled studies including 1484 implants and eight controlled studies (5 RCTs and 3 prospective studies) including 817 implants (451 implants in the non-graft group) were enrolled in this study. The survival rate of implants via the graft-free method was 98% (95%CI 96% to 100%). There was no significant difference in the survival rate between the non-graft group and the graft group (RR: 1.02; p = 0.18). No statistically significant difference in marginal bone loss was detected between the groups at 12 months (0.57, p = 0.07) or 36 months (0.05, p = 0.61). The endo-sinus bone gain in the non-graft group was significantly lower than in the graft group at 12 months (−1.10, p = 0.0001) and 36 months (−0.74, p = 0.02). Hence, the available evidence suggests that predictable results could be acquired through transalveolar sinus floor lift without bone grafting, while there may be a trend toward more endo-sinus bone gain with bone grafts