1 research outputs found
Ultrahigh-Resolution NMR Spectroscopy for Rapid Chemical and Biological Applications in Inhomogeneous Magnetic Fields
NMR
spectroscopy is a commonly used analytical technique in practical
applications, and its applicability is further promoted by pure chemical
shift techniques based on spectral simplification for analyses. Unfortunately,
magnetic field inhomogeneity caused by adverse experimental conditions
remains an obstacle restricting NMR applications. In this study, we
introduce a new NMR method for high-resolution pure shift proton (<sup>1</sup>H) NMR measurements in inhomogeneous magnetic fields. We demonstrate
that the method allows one to perform chemical analyses on complex
solutions in deshimmed magnetic fields, to obtain metabolite information
on intact biological tissues with intrinsic field inhomogeneities
and to achieve in situ electrochemical detection under externally
adverse field conditions. This approach is readily implemented on
common commercial NMR instruments without field shimming and locking
procedures, specialized hardware requirements as well as complicated
sample pretreatments. It provides an effective tool for NMR applications
to high-resolution chemical and biological measurements under inhomogeneous
magnetic field conditions