A way of relating instantaneous and finite screws based on the screw triangle product

It has been a desire to unify the models for structural and parametric analyses and design in the field of robotic mechanisms. This requires a mathematical tool that enables analytical description, formulation and operation possible for both finite and instantaneous motions. This paper presents a method to investigate the algebraic structures of finite screws represented in a quasi-vector form and instantaneous screws represented in a vector form. By revisiting algebraic operations of screw compositions, this paper examines associativity and derivative properties of the screw triangle product of finite screws and produces a vigorous proof that a derivative of a screw triangle product can be expressed as a linear combination of instantaneous screws. It is proved that the entire set of finite screws forms an algebraic structure as Lie group under the screw triangle product and its time derivative at the initial pose forms the corresponding Lie algebra under the screw cross product, allowing the algebraic structures of finite screws in quasi-vector form and instantaneous screws in vector form to be revealed.

A finite screw approach to type synthesis of three-DOF translational parallel mechanisms

This paper for the first time presents a finite screw approach to type synthesis of three-degree-of-freedom (DOF) translational parallel mechanisms (TPMs). Firstly, the finite motions of a rigid body, a TPM and its limbs are described by finite screws. Secondly, given the standard form of a limb with the specified DOF, the analytical expressions of the finite screw attributed to the limb are derived using the properties of screw triangle product, resulting in a full set of the 3-, 4- and 5-DOF limbs that can readily be used for determining all the potential topological structures of TPMs. Finally, the assembly conditions for type synthesis of TPMs are proposed by taking into account the inclusive relationship between the finite motions of a TPM and those of its limbs. The merit of this approach lies in that the limb structures can be formulated in a justifiable manner that naturally ensures the full cycle finite motion pattern specified to the moving platform

The role of long non-coding RNA in abdominal aortic aneurysm

The abdominal aortic aneurysm (AAA) is characterized by segmental expansion of the abdominal aorta and a high mortality rate. The characteristics of AAA suggest that apoptosis of smooth muscle cells, the production of reactive oxygen species, and inflammation are potential pathways for the formation and development of AAA. Long non-coding RNA (lncRNA) is becoming a new and essential regulator of gene expression. Researchers and physicians are focusing on these lncRNAs to use them as clinical biomarkers and new treatment targets for AAAs. LncRNA studies are beginning to emerge, suggesting that they may play a significant but yet unidentified role in vascular physiology and disease. This review examines the role of lncRNA and their target genes in AAA to increase our understanding of the disease’s onset and progression, which is crucial for developing potential AAA therapies

Neutrophil Extracellular Traps and Endothelial Dysfunction in Atherosclerosis and Thrombosis

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Neutrophils are a component of the innate immune system which protect against pathogen invasion; however, the contribution of neutrophils to cardiovascular disease has been underestimated, despite infiltration of leukocyte subsets being a known driving force of atherosclerosis and thrombosis. In addition to their function as phagocytes, neutrophils can release their extracellular chromatin, nuclear protein, and serine proteases to form net-like fiber structures, termed neutrophil extracellular traps (NETs). NETs can entrap pathogens, induce endothelial activation, and trigger coagulation, and have been detected in atherosclerotic and thrombotic lesions in both humans and mice. Moreover, NETs can induce endothelial dysfunction and trigger proinflammatory immune responses. Overall, current data indicate that NETs are not only present in plaques and thrombi but also have causative roles in triggering formation of atherosclerotic plaques and venous thrombi. This review is focused on published findings regarding NET-associated endothelial dysfunction during atherosclerosis, atherothrombosis, and venous thrombosis pathogenesis. The NET structure is a novel discovery that will find its appropriate place in our new understanding of cardiovascular disease. In addition, NETs have high potential to be further explored toward much better treatment of atherosclerosis and venous thromboembolism in clinic

Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells

Abstract The accumulation of foam cells in arterial intima and the accompanied chronic inflammation are considered major causes of neoatherosclerosis and restenosis. However, both the underlying mechanism and effective treatment for the disease are yet to be uncovered. In this study, we combined transcriptome profiling of restenosis artery tissue and bioinformatic analysis to reveal that NLRP3 inflammasome is markedly upregulated in restenosis and that several restenosis‐related DEGs are also targets of mulberry extract, a natural dietary supplement used in traditional Chinese medicine. We demonstrated that mulberry extract suppresses the formation of ox‐LDL‐induced foam cells, possibly by upregulating the cholesterol efflux genes ABCA1 and ABCG1 to inhibit intracellular lipid accumulation. In addition, mulberry extract dampens NLRP3 inflammasome activation by stressing the MAPK signaling pathway. These findings unveil the therapeutic value of mulberry extract in neoatherosclerosis and restenosis treatment by regulating lipid metabolism and inflammatory response of foam cells