Modified Slim-Disk Model Based on Radiation-Hydrodynamic Simulation Data: The Conflict Between Outflow and Photon Trapping

Photon trapping and outflow are two key physics associated with the supercritical accretion flow. We investigate the conflict between these two processes based on two-dimensional radiation-hydrodynamic (RHD) simulation data and construct a simplified (radially) one-dimensional model. Mass loss due to outflow, which is not considered in the slim-disk model, will reduce surface density of the flow, and if very significant, it will totally suppress photon trapping effects. If the photon trapping is very significant, conversely, outflow will be suppressed because radiation pressure force will be reduced. To see what actually occurs, we examine the RHD simulation data and evaluate the accretion rate and outflow rate as functions of radius. We find that the former monotonically decreases, while the latter increases, as the radius decreases. However, the former is kept constant at small radii, inside several Schwarzschild radii, since the outflow is suppressed by the photon trapping effects. To understand the conflict between the photon trapping and outflow in a simpler way, we model the radial distribution of the accretion rate from the simulation data and build up a new (radially) one-dimensional model, which is similar to the slim-disk model but incorporates the mass loss effects due to the outflow. We find that the surface density (and, hence, the optical depth) is much reduced even inside the trapping radius, compared with the case without outflow, whereas the effective temperature distribution hardly changes. That is, the emergent spectra do not sensitively depend on the amount of mass outflow. We conclude that the slim-disk approach is valid for interpreting observations, even if the outflow is taken into account.Comment: 15 pages, 5 figures, accepted for publication in PAS

Toxin-Induced and Genetic Animal Models of Parkinson's Disease

Parkinson's disease (PD) is a common progressive neurodegenerative disorder. The major pathological hallmarks of PD are the selective loss of nigrostriatal dopaminergic neurons and the presence of intraneuronal aggregates termed Lewy bodies (LBs), but the pathophysiological mechanisms are not fully understood. Epidemiologically, environmental neurotoxins such as pesticides are promising candidates for causative factors of PD. Oxidative stress and mitochondrial dysfunction induced by these toxins could contribute to the progression of PD. While most cases of PD are sporadic, specific mutations in genes that cause familial forms of PD have led to provide new insights into its pathogenesis. This paper focuses on animal models of both toxin-induced and genetically determined PD that have provided significant insight for understanding this disease. We also discuss the validity, benefits, and limitations of representative models

Glacier dynamics near the calving front of Bowdoin Glacier, northwestern Greenland

To better understand recent rapid recession of marine-terminating glaciers in Greenland, we performed satellite and field observations near the calving front of Bowdoin Glacier, a 3 km wide outlet glacier in northwestern Greenland. Satellite data revealed a clear transition to a rapidly retreating phase in 2008 from a relatively stable glacier condition that lasted for >20 years. Ice radar measurements showed that the glacier front is grounded, but very close to the floating condition. These results, in combination with the results of ocean depth soundings, suggest bed geometry in front of the glacier is the primary control on the rate and pattern of recent rapid retreat. Presumably, glacier thinning due to atmospheric and/or ocean warming triggered the initial retreat. In situ measurements showed complex short-term ice speed variations, which were correlated with air temperature, precipitation and ocean tides. Ice speed quickly responded to temperature rise and a heavy rain event, indicating rapid drainage of surface water to the bed. Semi-diurnal speed peaks coincided with low tides, suggesting the major role of the hydrostatic pressure acting on the calving face in the force balance. These observations demonstrate that the dynamics of Bowdoin Glacier are sensitive to small perturbations occurring near the calving front

Supervised Collective Classification for Crowdsourcing

Crowdsourcing utilizes the wisdom of crowds for collective classification via information (e.g., labels of an item) provided by labelers. Current crowdsourcing algorithms are mainly unsupervised methods that are unaware of the quality of crowdsourced data. In this paper, we propose a supervised collective classification algorithm that aims to identify reliable labelers from the training data (e.g., items with known labels). The reliability (i.e., weighting factor) of each labeler is determined via a saddle point algorithm. The results on several crowdsourced data show that supervised methods can achieve better classification accuracy than unsupervised methods, and our proposed method outperforms other algorithms.Comment: to appear in IEEE Global Communications Conference (GLOBECOM) Workshop on Networking and Collaboration Issues for the Internet of Everythin

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients

Objective To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels. Design Meta-analysis. Studies reviewed Therapeutic benefit of niacin, fibrates, and cholesteryl ester transfer protein (CETP) inhibitors on cardiovascular events (all cause mortality, coronary heart disease mortality, non-fatal myocardial infarction, and stroke). Results 117 411 patients were randomised in a total of 39 trials. All interventions increased the levels of high density lipoprotein cholesterol. No significant effect was seen on all cause mortality for niacin (odds ratio 1.03, 95% confidence interval 0.92 to 1.15, P=0.59), fibrates (0.98, 0.89 to 1.08, P=0.66), or CETP inhibitors (1.16, 0.93 to 1.44, P=0.19); on coronary heart disease mortality for niacin (0.93, 0.76 to 1.12, P=0.44), fibrates (0.92, 0.81 to 1.04, P=0.19), or CETP inhibitors (1.00, 0.80 to 1.24, P=0.99); or on stroke outcomes for niacin (0.96, 0.75 to 1.22, P=0.72), fibrates (1.01, 0.90 to 1.13, P=0.84), or CETP inhibitors (1.14, 0.90 to 1.45, P=0.29). In studies with patients not receiving statins (before the statin era), niacin was associated with a significant reduction in non-fatal myocardial infarction (0.69, 0.56 to 0.85, P=0.0004). However, in studies where statins were already being taken, niacin showed no significant effect (0.96, 0.85 to 1.09, P=0.52). A significant difference was seen between these subgroups (P=0.007). A similar trend relating to non-fatal myocardial infarction was seen with fibrates: without statin treatment (0.78, 0.71 to 0.86, P<0.001) and with all or some patients taking statins (0.83, 0.69 to 1.01, P=0.07); P=0.58 for difference. Conclusions Neither niacin, fibrates, nor CETP inhibitors, three highly effective agents for increasing high density lipoprotein levels, reduced all cause mortality, coronary heart disease mortality, myocardial infarction, or stroke in patients treated with statins. Although observational studies might suggest a simplistic hypothesis for high density lipoprotein cholesterol, that increasing the levels pharmacologically would generally reduce cardiovascular events, in the current era of widespread use of statins in dyslipidaemia, substantial trials of these three agents do not support this concept

Modeling the flow dynamics of Bowdoin Glacier, Qaanaaq region, northwestern Greenland

第6回極域科学シンポジウム分野横断セッション：[IA] 急変する北極気候システム及びその全球的な影響の総合的解明―GRENE北極気候変動研究事業研究成果報告2015―11月19日（木）　国立極地研究所 2階 大会議

Seasonal variations in the dynamics of Bowdoin Glacier, northwest Greenland

第6回極域科学シンポジウム分野横断セッション：[IA] 急変する北極気候システム及びその全球的な影響の総合的解明―GRENE北極気候変動研究事業研究成果報告2015―11月19日（木）　国立極地研究所１階交流アトリウ