49 research outputs found
Crab cavities for linear colliders
Crab cavities have been proposed for a wide number of accelerators and
interest in crab cavities has recently increased after the successful operation
of a pair of crab cavities in KEK-B. In particular crab cavities are required
for both the ILC and CLIC linear colliders for bunch alignment. Consideration
of bunch structure and size constraints favour a 3.9 GHz superconducting,
multi-cell cavity as the solution for ILC, whilst bunch structure and
beam-loading considerations suggest an X-band copper travelling wave structure
for CLIC. These two cavity solutions are very different in design but share
complex design issues. Phase stabilisation, beam loading, wakefields and mode
damping are fundamental issues for these crab cavities. Requirements and
potential design solutions will be discussed for both colliders.Comment: 3 pages. To be published in proceedings of LINAC 2008, Victoria,
Canad
Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus
The goal of this study is to clarify whether the expression of metallothionein (MT) could affect the prognosis and the metastatic potential of squamous cell carcinoma (SCC) of the oesophagus. In paraffin-embedded specimens resected from 57 patients, MT mRNA and protein expressions were detected by in situ hybridization and immunohistochemistry respectively. The expression of MT was evaluated in respect of clinicopathologic variables and patients' survival. MT mRNA expression was significantly associated with the proportion of lymph node metastasis (71% in MT mRNA-positive tumours vs 42% in MT mRNA-negative tumours; P = 0.0343) and that of distant metastasis (29% in MT mRNA-positive tumours vs 5% in MT mRNA-negative tumours; P = 0.0452). In respect of MT protein expression, the frequency of distant metastasis was more common in MT-positive tumours than in MT-negative tumours (30% in MT-positive tumours vs 8% in MT-negative tumours; P = 0.0446). The survival rate of the patients with MT protein-negative tumours was significantly better than that of the patients with MT protein-positive tumours (P = 0.0340). There was a positive correlation between the expression of MT protein and that of proliferating cell nuclear antigen (P = 0.0018). Therefore, we conclude that MT expression, both at the mRNA and protein levels, may be a potential marker predicting metastatic and proliferative activities of oesophageal SCC. © 1999 Cancer Research Campaig
An acid test: Facile SI-ARGET-ATRP of methacrylic acid
Atom transfer radical polymerization (ATRP) of methacrylic acid (MAA) is challenging. Herein is reported a study of conditions for facile surfaceâinitiated ATRP by activator regenerated electron transfer (SIâARGETâATRP) growth of polyâmethacrylic acid (PMAA) chains from a plasma polymer surface bearing surfaceâimmobilized αâbromoisobutyryl bromide, with no deoxygenation required. Factors that affect PMAA polymer growth off the surface under ARGETâATRP conditions are systematically investigated, such as monomer/catalyst ratio, solvent, and, most importantly, addition of salts and change of pH. While the concentrations of the copper catalyst and acid affect grafting, the most pronounced effect arises from the concentration of chloride ions. Adding 0.1 m NaCl and acidifying the reaction solution to pH 3 offers the best tradeâoff between reaction rate and reproducibility; yielding â60 nm thick PMAA graft polymers in 1 h under ambient conditions. Using this easily scalable recipe and surface analysis, the grafted polymers are verified to be pure PMAA and the graft coatings to be homogenous across a substrate of 100 mm diameter.Thomas D. Michl, Dimitri Jung, Andrea Pertoldi, Anna Schulte, Piotr Mocny, Harm-Anton Klok, Holger Schönherr, Carla Giles, Hans J. Griesser, and Bryan R. Coa