69 research outputs found
Students as co-creators of teaching approaches, course design and curricula: implications for academic developers
Within higher education, studentsâ voices are frequently overlooked in the design of teaching approaches, courses and curricula. In this paper we outline the theoretical background to arguments for including students as partners in pedagogical planning processes. We present examples where students have worked collaboratively in design processes along with the beneficial outcomes of these examples. Finally we focus on some of the implications and opportunities for academic developers of proposing collaborative approaches to pedagogical planning
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Doc Hollywood
In âDoc Hollywoodâ (1991), Dr. Benjamin Stone (portrayed by Michael J. Fox in the film) is an emergency room doctor eager to begin a lucrative career as a plastic surgeon in Beverly Hills. Lost during his cross-country drive, Stone crashes into the fence of the local judge in a small town and is sentenced to community service providing medical services to the town. Upon completing his service, will he realize where he truly belongs?
Author, producer and the real âDoc Hollywood,â Dr. Neil Shulman shares scenes from the film and discusses clinical ethics, stereotypes, and the challenges of providing rural health care
Doc Hollywood
In âDoc Hollywoodâ (1991), Dr. Benjamin Stone (portrayed by Michael J. Fox in the film) is an emergency room doctor eager to begin a lucrative career as a plastic surgeon in Beverly Hills. Lost during his cross-country drive, Stone crashes into the fence of the local judge in a small town and is sentenced to community service providing medical services to the town. Upon completing his service, will he realize where he truly belongs?
Author, producer and the real âDoc Hollywood,â Dr. Neil Shulman shares scenes from the film and discusses clinical ethics, stereotypes, and the challenges of providing rural health care
Effects of vector cutting on its recombination with the chromosomal immunoglobulin gene in hybridoma cells
Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: patient-centred outcomes
BACKGROUND: Patient-centred outcomes are increasingly used in perioperative clinical trials. The Standardised Endpoints in Perioperative Medicine (StEP) initiative aims to define which measures should be used in future research to facilitate comparison between studies and to enable robust evidence synthesis. METHODS: A systematic review was conducted to create a longlist of patient satisfaction, health-related quality of life, functional status, patient well-being, and life-impact measures for consideration. A three-stage Delphi consensus process involving 89 international experts was then conducted in order to refine this list into a set of recommendations. RESULTS: The literature review yielded six patient-satisfaction measures, seven generic health-related quality-of-life measures, eight patient well-being measures, five functional-status measures, and five life-impact measures for consideration. The Delphi response rates were 92%, 87%, and 100% for Rounds 1, 2, and 3, respectively. Three additional measures were added during the Delphi process as a result of contributions from the StEP group members. Firm recommendations have been made about one health-related quality-of-life measure (EuroQol 5 Dimension, five-level version with visual analogue scale), one functional-status measure (WHO Disability Assessment Schedule version 2.0, 12-question version), and one life-impact measure (days alive and out of hospital at 30 days after surgery). Recommendations with caveats have been made about the Bauer patient-satisfaction measure and two life-impact measures (days alive and out of hospital at 1 yr after surgery, and discharge destination). CONCLUSIONS: Several patient-centred outcome measures have been recommended for use in future perioperative studies. We suggest that every clinical study should consider using at least one patient-centred outcome within a suite of endpoints
Chronic Myeloproliferative Disorders: Improved Platelet Aggregation following Venesection
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